One Symptom, Many Causes: Rethinking Anemia

The Longevity Podcast: Optimizing HealthSpan & MindSpan

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3d ago 12:26

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We unpack anemia as an oxygen delivery failure, tracing two main pathways: a factory slowdown in the bone marrow and the rapid destruction of red blood cells. We explain symptoms, exam clues, lab patterns, and why treatment must match the root cause, from iron pills to splenectomy.
• Red blood cell lifespan and hemoglobin’s role
• Production failures from iron and B12 deficiency
• Pernicious anemia as an absorption autoimmunity
• Chronic inflammation and drug-induced marrow suppression
• Hemolysis from sickle cell and mechanical shear
• Autoimmune hemolytic anemia and hypersplenism
• Symptom patterns and physical exam signs
• Lab clues from morphology, reticulocytes, bilirubin
• Targeted treatments, transfusions, steroids, splenectomy
• When to seek care and consider genetic testing
This podcast is created by Ai for educational and entertainment purposes only and does not constitute professional medical or health advice. Please talk to your healthcare team for medical advice.

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Chapters

1. Defining Anemia And Oxygen Delivery (00:00:00)

2. RBC Lifespan And System Failures (00:01:52)

3. Pathway A: Factory Slowdown (00:02:28)

4. Iron Vs B12 And Pernicious Anemia (00:03:07)

5. Chronic Inflammation And Marrow Suppression (00:03:44)

6. Pathway B: Rapid Destruction (00:04:19)

7. Sickle Cell And Mechanical Hemolysis (00:05:02)

8. Immune Attack And Hypersplenism (00:06:05)

9. Symptoms, Exam Clues, And Tests (00:06:42)

10. Jaundice And Bilirubin Overload (00:08:09)

11. Treatment Spectrum And Prevention (00:09:01)

12. Transfusions, Steroids, And Splenectomy (00:10:09)

13. When To Call A Doctor (00:11:12)

14. The Big Takeaway And Adaptation (00:12:02)

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