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Precision Brain Health
Manage episode 517924597 series 2993661
We test a bold idea: your baseline gray matter pattern can predict whether multidomain prevention actually protects your brain. By clustering MRI scans into six subtypes, we uncover who responds, who doesn’t, and how vascular risks tip the balance.
• global dementia risk and why prevention must scale
• strengths and limits of the FINGER multidomain model
• heterogeneity in gray matter masks average effects
• six MRI-derived structural subtypes with distinct thinning patterns
• vascular and demographic fingerprints across clusters
• diffuse and frontal thinning groups as top responders
• posterior thinning groups as structural nonresponders
• neuroplasticity, reserve, and ceiling effects as mechanisms
• tailoring prevention by brain subtype and risk profile
• replication needs across the worldwide FINGER network
This podcast is created by Ai for educational and entertainment purposes only and does not constitute professional medical or health advice. Please talk to your healthcare team for medical advice.
Never miss an episode—subscribe on your favorite podcast app!
Chapters
1. Why Prevention Matters (00:00:00)
2. Enter The FINGER Trial (00:00:18)
3. The Heterogeneity Problem (00:00:52)
4. Clustering The Brain Scans (00:02:35)
5. Six Structural Subtypes (00:03:05)
6. Risk Profiles Across Clusters (00:04:16)
7. Average Effects Disappear (00:06:43)
8. Stratification Reveals Responders (00:08:07)
9. Why Thinner Cortices Benefit More (00:09:25)
10. Nonresponders And Posterior Thinning (00:11:14)
11. Toward Personalized Neuroprevention (00:12:31)
12. Caveats And The Next Frontier (00:14:03)
90 episodes
Manage episode 517924597 series 2993661
We test a bold idea: your baseline gray matter pattern can predict whether multidomain prevention actually protects your brain. By clustering MRI scans into six subtypes, we uncover who responds, who doesn’t, and how vascular risks tip the balance.
• global dementia risk and why prevention must scale
• strengths and limits of the FINGER multidomain model
• heterogeneity in gray matter masks average effects
• six MRI-derived structural subtypes with distinct thinning patterns
• vascular and demographic fingerprints across clusters
• diffuse and frontal thinning groups as top responders
• posterior thinning groups as structural nonresponders
• neuroplasticity, reserve, and ceiling effects as mechanisms
• tailoring prevention by brain subtype and risk profile
• replication needs across the worldwide FINGER network
This podcast is created by Ai for educational and entertainment purposes only and does not constitute professional medical or health advice. Please talk to your healthcare team for medical advice.
Never miss an episode—subscribe on your favorite podcast app!
Chapters
1. Why Prevention Matters (00:00:00)
2. Enter The FINGER Trial (00:00:18)
3. The Heterogeneity Problem (00:00:52)
4. Clustering The Brain Scans (00:02:35)
5. Six Structural Subtypes (00:03:05)
6. Risk Profiles Across Clusters (00:04:16)
7. Average Effects Disappear (00:06:43)
8. Stratification Reveals Responders (00:08:07)
9. Why Thinner Cortices Benefit More (00:09:25)
10. Nonresponders And Posterior Thinning (00:11:14)
11. Toward Personalized Neuroprevention (00:12:31)
12. Caveats And The Next Frontier (00:14:03)
90 episodes
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