How Hypertension Shapes The Brain Years Before Memory Fades

The Longevity Podcast: Optimizing HealthSpan & MindSpan

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2d ago 13:06

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We trace how everyday blood pressure quietly influences the earliest Alzheimer’s changes, years before memory shifts. PET imaging, CSF biomarkers, and pulse pressure reveal two pathways: more plaque buildup and poorer brain clearance.
• cohorts of unimpaired adults across ALFA+, EPAD, and AMYPAD
• amyloid PET centiloids tied to higher SBP and PP at baseline
• longitudinal plaque accumulation linked to higher DBP
• CSF signature clarified by adjusting for Aβ40 to reflect clearance
• arterial stiffness and pulse pressure connecting to p‑tau in older adults
• two‑mechanism model: physical buildup and impaired fluid turnover
• practical frame for midlife hypertension control as brain protection
• limits of selected cohorts and implications for broader populations
Have that conversation with your doctor about your own numbers
This podcast is created by Ai for educational and entertainment purposes only and does not constitute professional medical or health advice. Please talk to your healthcare team for medical advice.

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Chapters

1. Setting The Research Goal (00:00:00)

2. Blood Pressure Meets Preclinical Alzheimer’s (00:00:10)

3. Who Was Studied And Why It Matters (00:00:31)

4. Tools: CSF Markers And Amyloid PET (00:00:53)

5. Centiloids Explained (00:01:50)

6. Cross‑Sectional Links To Higher Amyloid (00:03:16)

7. Longitudinal Diastolic Pressure Effect (00:04:16)

8. Why Resting Pressure May Matter Most (00:05:24)

9. PET Takeaway: Physical Plaque Accumulation (00:06:05)

10. The CSF Twist Challenges Assumptions (00:06:44)

11. Adjusting For Aβ40 Reveals Clearance (00:07:18)

12. Two Hits: Build‑Up And Bad Clearance (00:08:03)

13. Pulse Pressure And Arterial Stiffness (00:08:12)

14. Age Interaction And Tau Injury (00:09:02)

15. Clinical Meaning: Manage Hypertension (00:10:26)

16. Cohort Limits And Real‑World Impact (00:11:52)

17. Final Reflections And Next Steps (00:12:49)

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