CM#6: Cancer, Metformin, and the mTOR Pathway: Separating Fact from Fiction in Insulin Mimetic Therapy

Architect of Resilience

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5M ago 23:13

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Chris Duffin sits down with expert guest Anthony Castor to delve deep into the fascinating world of insulin mimetics, glucose metabolism, and their implications for overall health and aging. The conversation kicks off with an examination of metformin's widespread use in diabetes management and its controversial potential benefits in cancer prevention, as highlighted in a recent study that casts doubt on its anti-cancer efficacy.

Anthony and Chris explore the intricacies of balancing key cellular pathways—AMPK and mTOR—and their roles in muscle metabolism and aging. They discuss how the AMPK pathway acts as a guardian of energy preservation in the cell, especially under conditions of low nutrient availability, while mTOR is pivotal for muscle protein synthesis and energy expenditure. They also touch upon the impact of gut microbiome shifts on insulin sensitivity and how products like berberine and metformin can influence these pathways, sometimes to the detriment of muscle mass gain.

Metformin and Gut Microbiome

Positive impacts of metformin on gut microbiome
GI disturbances related to insulin mimetics
Role of AMPK signaling in energy preservation and muscle protein synthesis
Benefits of products like berberine, banaba leaf extract, and alpha lipoic acid
Hormonal support and muscle mass considerations

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