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Since cardiovascular disease is one of the leading causes of death in the U.S., cardiology physicians are continuously working to better understand this common disease and to help patients improve their heart health. And here to assist cardiology physicians in this mission is Heart Matters, a series dedicated to covering essential strategies and research efforts focusing on all types of heart problems, including coronary artery diseases, heart attacks, high cholesterol, high blood pressure, ...
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"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Eac ...
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Get to the heart of the most recent advances in lipid management and cardiovascular disease with Lipid Luminations, which features scientific and clinical research updates, novel emerging treatment options, and best practices in patient care.
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Experience these in-depth interviews with the fighters that BEAT their chronic health issues NATURALLY by following a 120 program designed by Dr. Reese. These interviews were the catalyst for Dr. Reese writing the popular book, THE PEOPLE VS CHRONIC ILLNESS: The Evidence, Knowledge and Solution to Becoming Pain & Drug-Free.
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The Jersey PodCats

Danielle Woolley & Elizabeth Gearhart

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If you love talking about cats, but your friends and family are kind of over it, this is the podcast for you! Join your hosts, Danielle Woolley and Elizabeth Gearhart, on The Jersey PodCats for entertaining conversations with everyday cat lovers talking about life, cats and everything in between! Follow us on Facebook, Instagram, Youtube and everywhere you listen to podcasts.
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Dr Maulfair's 40+ years of clinical experience offering treatment protocols designed to avoid prescription drugs has resulted in thousands of patients regaining health and many more avoiding health problems in the first place. Aging gracefully without complications from chronic, degenerative diseases and health problems IS within your reach and very possible with his medical care. Get Answers Instead of Prescriptions with this weekly podcast.
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Dr. Alok Purohit (PhD)

Dr. Alok Purohit

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Dr Alok Purohit is a practicing life & Health coach, Ex Corporate CEO, Certified by ICF, he specializes in executive/entrepreneur coaching and family business coaching. Certified by EACCME, He coaches individuals on diabetes and other metabolic/ Lifestyle diseases, mostly helps them to manage/reverse their condition through education, empowerment and holistic lifestyle modification. You may find empowering podcasts relating to life coaching, health and nutrition and specifically on diabetes ...
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🧬 New NEJM data on Olezarsen! In patients with severe hypertriglyceridemia, monthly RNA-targeted therapy delivered major triglyceride reductions (−62% to −72%) and a significant drop in acute pancreatitis risk (rate ratio 0.15). ✨ Improvements extended to ApoC-III, remnant cholesterol, and non-HDL cholesterol, with consistent benefits across both C…
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🚀 A milestone moment in lipid therapeutics! The new JAMA trial on the oral PCSK9 inhibitor Enlicitide reports a ~60% reduction in LDL-C, with parallel decreases in ApoB and Lp(a)—all on top of maximally tolerated statin therapy. For individuals with heterozygous familial hypercholesterolemia (HeFH)—where reaching LDL targets remains a persistent ch…
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☕ DECAF Trial insight! A new JAMA study shows that daily caffeinated coffee may lower recurrence of atrial fibrillation compared with abstinence. Patients drinking ~1 cup/day had 47% recurrence vs 64% with abstinence (HR 0.61, p=0.01) 📉💓 No major safety concerns—challenging long-held beliefs that coffee is proarrhythmic. 💡Takeaway: For many patient…
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🚨 New insights from The Lancet 🚨 A major individual-patient-data meta-analysis (6 RCTs, 8,836 patients) shows that complete revascularisation in acute myocardial infarction significantly reduces cardiovascular death, all-cause mortality, and recurrent MI. 💓📉 Benefits were consistent across age, sex, STEMI/NSTEMI, and lesion characteristics — streng…
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📘 New Evidence from NEJM In a large meta-analysis of 17,801 patients with preserved LVEF after MI, beta-blockers did not reduce death, recurrent MI, or heart failure. Event rates were low, and outcomes were similar with or without therapy. 🫀📊 This clarifies practice for a growing post-MI population with LVEF ≥50%—precision matters more than traditi…
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Most heart attacks don’t start with a clogged artery! They start with a microscopic storm — a small, invisible wound inside the artery wall. That storm begins decades before symptoms, sometimes before high school. By the time someone hits their forties or fifties, the real question isn’t whether atherosclerosis has begun…It’s how far it’s already g…
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📢 ADAPT AF-DES Trial — A Safer Path Forward! In patients with atrial fibrillation beyond 1 year after drug-eluting stent implantation, NOAC monotherapy delivered striking benefits over combination therapy. ✅ Lower net adverse clinical events ✅ Marked reduction in major/CRNM bleeding ✅ Similar ischemic protection A beautifully simple strategy with m…
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🌊 OCEAN Trial offers fresh insight into antithrombotic therapy after successful AF ablation. In 1284 patients followed for 3 years, event rates were remarkably low 🌟. Rivaroxaban did not show superiority over aspirin for preventing stroke, systemic embolism, or covert embolic events, while bleeding risk was higher with anticoagulation. 🧠 96% had no…
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In this week's episode of Barbell Shrugged, Anders Varner, Doug Larson, Coach Travis Mash, and Dr. Chris Perry dive deep into the real science of muscle mass, why it's the single most important tissue in the human body and what happens when you don't have enough of it. They cover everything from how muscle mass impacts disease risk, hormone balance…
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🧠 John Locke: Experience • Liberty • Toleration Born a physician-philosopher, Locke championed empiricism — the idea that knowledge begins with experience, not dogma. His tabula rasa shaped modern psychology, while his Two Treatises of Government defined rights, consent, and freedom that echo through modern democracies. For clinicians, his legacy r…
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🚀 VESALIUS-CV delivers powerful evidence: in high-risk patients without prior MI or stroke, evolocumab significantly reduced 3-point MACE by 25% and 4-point MACE by 19%, with LDL-C lowered to a median of 45 mg/dL. 💡 These results expand the horizon of prevention, showing that deep LDL reduction is both safe and effective in averting first cardiovas…
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🫀 Septic Shock, Refined at the Fingertips ⏱️ A powerful new JAMA (2025) trial brings us one step closer to truly personalized resuscitation. The ANDROMEDA-SHOCK-2 study shows that targeting capillary refill time (CRT) — a simple bedside sign — can shorten time on organ support vs usual care, without increasing mortality. Key insight: Sometimes the …
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🚨 SOFA-2 arrives — a thoughtful evolution in critical care scoring 🧠🫁🫀 After nearly 30 years, the SOFA score has been modernized using data from >3.3 million ICU patients across 9 countries. The updated SOFA-2 incorporates contemporary respiratory and cardiovascular supports (HFNC, NIPPV, vasopressors, ECMO) and refines thresholds while preserving …
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SOFA-2 is here — a major advance in assessing organ dysfunction in critical illness 🧠🫁❤️ Three decades after the original SOFA score, this updated framework reflects modern ICU practice — integrating contemporary organ support (ventilation, vasopressors, RRT), delirium recognition, and global feasibility across resource settings 🌍📊 Validated in 3.3…
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💔 Peripartum Cardiomyopathy: When a Mother's Heart Fights for Two Peripartum cardiomyopathy is a leading yet often missed cause of maternal morbidity and mortality—striking late in pregnancy or months postpartum. Early suspicion, timely echo, and guideline-directed therapy save lives. 🩺 🧠 Bromocriptine, careful anticoagulation, and multidisciplinar…
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Rethinking "default lines" in the ICU 🧠🚑 A landmark NEJM trial shows that in patients with shock, deferring arterial catheterization and using automated cuff monitoring was noninferior for 28-day mortality — and reduced catheter-related complications. A gentle reminder: not every sick patient needs a needle to be well cared for. Precision isn't onl…
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🌙 Bright Nights, Higher Heart Risk ❤️‍🩹 New findings in JAMA Network Open highlight that greater exposure to artificial light at night is associated with significantly increased risks of coronary artery disease, myocardial infarction, heart failure, atrial fibrillation, and stroke — independent of sleep duration, lifestyle factors, and genetics. 💡 …
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The immune clock starts earlier than we think ⏳🧬 A landmark Nature study shows that immune aging begins quietly in midlife — decades before clinical frailty. Using >16M single-cell profiles and longitudinal vaccine responses, researchers found: • Stable, early transcriptional drift in naïve & memory T cells • A subtle TH2 shift that may weaken anti…
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In this episode, Anders Varner, Doug Larson, and Travis Mash sit down for a story that is equal parts comeback and evolution. After a hip replacement and years away from competition, Mash, now over 50 years old, stepped back onto the powerlifting platform to go nine for nine and set new age group world records. He breaks down how he rebuilt his bod…
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🫀 TAVR or SAVR? The 7-Year Truth New 7-year results from the PARTNER-3 trial (NEJM) show that in low-risk patients with severe symptomatic aortic stenosis, TAVR holds pace with surgery — delivering comparable survival, stroke rates, rehospitalization, valve durability, and quality-of-life outcomes. 🔎 Highlights • Composite events: 34.6% (TAVR) vs 3…
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🌿 Spinoza: Reason, Nature, Freedom Today's deck explores Baruch Spinoza — the quietly revolutionary Dutch philosopher who shaped rationalism, modern biblical criticism, and secular democracy. He saw God = Nature, championed intellectual freedom, and argued that understanding our emotions transforms them — not far from cognitive-behavioral ideas we …
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A new era for complex mitral regurgitation. The ENCIRCLE pivotal trial in The Lancet reports that fully percutaneous, transfemoral, transseptal TMVR (SAPIEN M3) achieved durable MR reduction (≈96% ≤1+ at 1 year), low early mortality, and meaningful improvement in symptoms and quality of life for patients unsuitable for surgery or TEER. A third path…
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🧬 Can we rejuvenate the aging immune system? A remarkable Nature Biotechnology study shows that a rare population of periostin-positive mesenchymal niche cells can rebuild the adult thymus, recruit new T-cell progenitors, and restore immune responses after injury. By harnessing CCL19-expressing stromal support, the authors demonstrate a path toward…
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🩺🎗️ Cardio-Oncology Insight: Not Every Breast Cancer Survivor Needs a Cardiologist As breast cancer survivorship grows, understanding who truly benefits from long-term cardiac follow-up becomes essential. An important editorial in JAMA Oncology underscores a key principle: risk-stratified care, not reflex surveillance. 👩‍⚕️🔍 Age and traditional car…
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🧬 Can we rejuvenate the aging immune system? A new Nature Aging trial suggests we might be closer than we thought. In 50 healthy adults aged 45–70, urolithin A—a mitophagy activator—improved immune fitness over just 28 days: ✅ ↑ naïve CD8⁺ T cells ✅ ↓ exhaustion markers (TOX) ✅ ↑ mitochondrial biogenesis (PGC-1α) ✅ ↑ fatty-acid oxidation capacity ✅…
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🫀 Personalizing DAPT: When "One Size Fits All" Fails 🕊️💊 The HOST-BR trial in The Lancet offers an important clinical lesson: Bleeding risk should guide antiplatelet duration after PCI — not habit, not inertia. 🔍 Key insight In ARC-HBR patients, 1-month DAPT was not non-inferior to 3 months In non-HBR patients, 3-month DAPT was non-inferior to 12 m…
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🚨 New Pharmacotherapy for Obstructive Sleep Apnoea 🌙💊 In a landmark Phase 2 trial published in The Lancet, sultiame— a carbonic anhydrase inhibitor—showed dose-dependent reduction in AHI and improved nocturnal oxygenation in adults with moderate–severe OSA. 💡 Key insights: • 298 participants across 5 European countries • 200 mg daily delivered the …
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📢 New Study Alert 🩺💊 In JAMA Internal Medicine, a national analysis reveals that using the PREVENT risk calculator (vs Pooled Cohort Equations) dramatically reduces the number of U.S. adults aged 40–59 eligible for aspirin in primary prevention of cardiovascular disease. Among 7.6 million current aspirin users, >96% wouldn't qualify by PREVENT 🤯. T…
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LDL may get all the blame — but there’s a darker twin hiding in the shadows. Same cholesterol core. Same ApoB backbone. But with one sinister twist: a sticky tail called apolipoprotein(a). That extra piece transforms an ordinary LDL particle into something far more dangerous. Meet Lipoprotein(a) — or Lp(a) — one of the strongest, most under-recogni…
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🧠 TACSI Trial in NEJM (Sep 2025) challenges the status quo on dual antiplatelet therapy after CABG for ACS! 👨‍⚕️ 2201 patients across 5 Nordic countries 💊 Ticagrelor + Aspirin ≠ better outcomes vs Aspirin alone 📉 No reduction in death, MI, stroke, or revascularization 🩸 But bleeding (4.9% vs 2.0%) & dyspnea (18.2% vs 6.4%) increased 📚 Guidelines ma…
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🧪 NEO-MINDSET Trial 🇧🇷 published in NEJM asks: Can we safely drop aspirin early after PCI in acute coronary syndromes (ACS)? 💊 Monotherapy with ticagrelor/prasugrel reduced bleeding 🩸 but increased early ischemic events 💥 vs dual antiplatelet therapy (DAPT). ❗ Noninferiority for major adverse cardiovascular events was not met. 🔍 DAPT still stands t…
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🚨 New in NEJM — The ALASCCA Trial 🧬 Low-dose aspirin (160 mg/day) reduced colorectal cancer recurrence in patients with PIK3CA, PIK3R1, or PTEN mutations 🎯 ✅ 3-year recurrence: 7.7% (aspirin) vs 14–17% (placebo) ✅ Group A HR: 0.49 | Group B HR: 0.42 ✅ NNT as low as 6 in stage III rectal cancer 💥 ⚠️ Slight increase in adverse events 🧠 Editorial call…
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In this episode, neuroscientist and U.S. Army sleep expert Dr. Allison Brager joins Anders Varner, Doug Larson, and Travis Mash to explore the real science behind sleep, recovery, and wearable technology. They discuss which devices actually deliver useful data, such as the Oura Ring for sleep tracking and Garmin for cardiovascular measurements, and…
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💡 TARGET-FIRST trial (NEJM, Aug 2025) shows that in low-risk AMI patients post-PCI with complete revascularization, stopping aspirin after 1 month and continuing P2Y12 monotherapy is noninferior to dual antiplatelet therapy—with 54% fewer bleeding events 🩸🛑💊 ⚖️ A modern, patient-tailored antiplatelet strategy—backed by potent P2Y12 inhibitors and s…
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💡 "Cogito, ergo sum" — I think, therefore I am. René Descartes laid the foundation of modern Western philosophy and scientific reasoning, linking algebra to geometry, and mind to body. 🧠📐 His legacy reminds healthcare professionals to unite reason with compassion — science with soul. ❤️⚕️By MasterMedFacts LLC
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💊🫀 Aspirin in the Crosshairs? The AQUATIC Trial (NEJM, Aug 2025) raises sharp questions on dual-pathway therapy in chronic coronary syndrome (CCS) patients already on long-term anticoagulation. 📉 Adding aspirin led to: • ↑ Ischemic events (HR 1.53; P=0.02) • ↑ Mortality (HR 1.72; P=0.01) • ↑ Major bleeding (HR 3.35; P) 🧠 Takeaway: More isn't always…
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🧠💥 Could lead poisoning have helped shape human evolution? A bold new hypothesis suggests that Homo sapiens may have survived while Neanderthals and Denisovans vanished—thanks to genetic defenses against environmental lead. 🧬 By analyzing fossil teeth 🦷 and testing brain organoids 🧪, researchers found that ancient lead exposure disrupted key langua…
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🚨 New in Nature 🧬: Groundbreaking study reveals how HMGN1, a dosage-sensitive epigenetic regulator on chromosome 21, reprograms atrioventricular cardiomyocytes into a ventricular fate—driving congenital heart defects in Down syndrome 💔🫀. Using hiPSCs, single-cell RNA sequencing, and a CRISPRa CROP-seq screen, researchers pinpoint HMGN1 as a causal …
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🚭 Lung Cancer in Nonsmokers – a hidden epidemic affecting up to 20% of global cases 🌍. Unlike tobacco-related disease, this form often strikes younger, female, and Asian populations, with EGFR and ALK mutations driving tumors 🔬. Despite low mutation burden and no smoking history, these patients benefit immensely from targeted therapies like osimert…
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👟 Just 2 Days Can Make a Difference! 🧓📉 In a large cohort of 13,547 older women (mean age 72), walking ≥4,000 steps/day on even 1–2 days/week was linked to a 26% lower mortality and 27% lower cardiovascular disease risk 💥. Those walking ≥3 days/week had even greater benefits! 📉 Higher step thresholds (up to 7,000/day) showed further mortality reduc…
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🧓 Aging skin, fading flow. This 2025 Nature study uncovers how dermal capillary-associated macrophages (CAMs) decline with age—preceding microvascular dysfunction and impaired blood flow. 🧬 Using intravital imaging and macrophage fate mapping in mice (and validating in humans!), the authors reveal that CAMs are not replenished unless triggered by i…
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🫀📉 Published in The Lancet (Oct 22, 2025): SELECT trial investigators report that semaglutide reduced MACE by 20% in patients with obesity but without diabetes—independent of weight loss. Waist circumference, not weight, tracked with outcomes, yet explained only 33% of the benefit. This landmark analysis redefines GLP-1RAs as disease-modifying agen…
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Hair Loss in Women" (The New England Journal of Medicine 2025; DOI 10.1056/NEJMcp2412146) 📄, and it's a must‑listen for anyone in clinical practice or research. The piece highlights that female‑pattern hair loss increases with age and is closely tied to hormonal status, and that treatments span from topical 5% minoxidil or low‑dose oral minoxidil t…
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🔍 New in The Lancet! A massive network meta-analysis of 94 RCTs (105,435 patients) reveals that antidepressants impact far more than mood 🧠—they alter weight ⚖️, glucose 🩸, BP 💓, lipids 🧬, and liver enzymes 🧪. Agomelatine 🌙 may lower weight, while nortriptyline 📈 raises heart rate. Time to rethink side-effect profiles when prescribing! 📚 Pills, Pre…
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🧬 Her Genes, His Risk, Our Mind 💡 New insights from Thomas et al., Nature Communications (2025) — summarized beautifully by Na Cai in Nature News & Views. Women carry a heavier polygenic burden for major depressive disorder (MDD), with ~6,000 female-specific variants and stronger genetic links to metabolic traits like BMI and metabolic syndrome. 🧠 …
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🦷🫀 New Findings Linking Oral Health to Heart Attacks! 🧬🧫 Groundbreaking research in JAHA reveals that viridans streptococci, common oral bacteria, form biofilms in atherosclerotic plaques that evade immune detection. These stealthy invaders trigger innate and adaptive immune responses, correlating with plaque rupture, myocardial infarction, and sud…
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🧠 Why Does Alzheimer's Affect More Women Than Men? New insights from JAMA Medical News reveal that the answer goes far beyond longevity. 🌸 Biology, hormones, and even social factors intertwine — from estrogen decline and X chromosome genetics to APOE4 risks and underdiagnosis due to stronger verbal memory. Women make up two-thirds of all Alzheimer'…
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With over a decade of experience, Kenny Santucci has made himself a known as one of New York City's top trainers and a thought leader in the health and wellness industry. Brand ambassador for Michelob Ultra and Fitaid, Technogym Master Trainer, host of the Fitaid Morning Show, Michelob Ultra MOVEMENT Fitness Festival, Model Beach Volleyball, and mo…
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🚨 New Study Alert 🕒 Can when you eat improve how you feel? This open-label pilot study shows that Time-Restricted Eating (TRE) — limiting food intake to an 8–10 hour window — significantly improved: ✅ Quality of Life (↑ SF-36 & ↓ MAPS scores) ✅ Orthostatic Heart Rate (↓ by 11 bpm, p ✅ Mitochondrial ATP production (↑, p TRE may offer a safe, feasibl…
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🌟 Guru Nanak (1469–1539 CE): The Voice of Oneness & Compassion 🌟 From Ik Onkar (One God) to Seva (selfless service), Guru Nanak's message transcends faith — reminding us that true spirituality lies in equality, honesty, and compassion. 🕊️ His principles — Naam Japo (meditate), Kirat Karo (work honestly), Vand Shhako (share with others) — continue t…
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