Rethinking Immune Aging: It Starts Sooner Than We Think 💡🩸

Dr RR Baliga's "Got Knowledge Doc" Podkast

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1d ago 4:23

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The immune clock starts earlier than we think ⏳🧬

A landmark Nature study shows that immune aging begins quietly in midlife — decades before clinical frailty.

Using >16M single-cell profiles and longitudinal vaccine responses, researchers found:

• Stable, early transcriptional drift in naïve & memory T cells

• A subtle TH2 shift that may weaken antiviral antibody quality

• Reduced IgG class-switching to repeat flu antigens (e.g., B/Phuket)

• No acceleration from CMV infection despite compositional shifts

The message?

Immune aging is gradual, not abrupt — and midlife may be the window for intervention.

Precision immunology will increasingly mean precision geroscience.

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