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1. ππ©ΈβοΈ Aspirin, Anticoagulants & Harm: Rethinking Dual Therapy in Stable CAD
Manage episode 516050933 series 2740117
ππ« Aspirin in the Crosshairs?
The AQUATIC Trial (NEJM, Aug 2025) raises sharp questions on dual-pathway therapy in chronic coronary syndrome (CCS) patients already on long-term anticoagulation.
π Adding aspirin led to:
β’ β Ischemic events (HR 1.53; P=0.02)
β’ β Mortality (HR 1.72; P=0.01)
β’ β Major bleeding (HR 3.35; P<0.001)
π§ Takeaway: More isn't always better. In high-risk CCS, aspirin may harm more than help.
π Read: https://www.nejm.org/doi/full/10.1056/NEJMoa2507532
#Cardiology #Antiplatelet #NEJM #PrecisionMedicine #AQUATICTrial
753 episodes
Manage episode 516050933 series 2740117
ππ« Aspirin in the Crosshairs?
The AQUATIC Trial (NEJM, Aug 2025) raises sharp questions on dual-pathway therapy in chronic coronary syndrome (CCS) patients already on long-term anticoagulation.
π Adding aspirin led to:
β’ β Ischemic events (HR 1.53; P=0.02)
β’ β Mortality (HR 1.72; P=0.01)
β’ β Major bleeding (HR 3.35; P<0.001)
π§ Takeaway: More isn't always better. In high-risk CCS, aspirin may harm more than help.
π Read: https://www.nejm.org/doi/full/10.1056/NEJMoa2507532
#Cardiology #Antiplatelet #NEJM #PrecisionMedicine #AQUATICTrial
753 episodes
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