Best Protein Engineering Podcasts (2025)

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Episode: 77 - Derek Lowe on AI and the US Biotech Ecosystem 42:25

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5h ago42:25

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September 16, 2025 | With the rise of AI and automation, what is the core human skill in drug discovery that is and will be valuable in the future? Derek Lowe, director of Chemical Biology Therapeutics at Novartis and author of the In the Pipeline blog, discusses the impact of AI—and non-AI technologies—on the business of drug making. With host Chr…

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20VC: General Catalyst CEO Hemant Taneja on The Future of Venture Capital: Chanel vs Walmart | Lessons Scaling GC to $40BN in AUM | Investing $5BN+ Into Stripe Over 14 Rounds | Investing Hundreds of Millions ... 1:27:19

5h ago1:27:19

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Hemant Taneja is the CEO and leader of General Catalyst, the firm he has scaled over the last decade into one of the largest with over $40BN in AUM. He has been one of the most influential investors of the past two decades, leading early bets in Stripe, Snap, Gusto, Samsara, Grammarly, and Canva. He also played a pivotal role in Livongo’s $18.5B me…

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20VC: Why 90% of Founders Build Startups Wrong | Why AI Growth Rates are Sustainable & Remote Work is BS and the AI Talent War | Competing with Brett Taylor and Sierra: Who Wins the Customer Service War ... 59:59

3d ago59:59

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Jesse Zhang is the Co-Founder and CEO @ Decagon, the conversational AI platform for customer experience. As one of the fastest growing companies in the valley, they have raised over $230M at a last round price of $1.5BN. Prior to Decagon, Jesse founded Lowkey (acquired by Niantic), studied CS at Harvard, and worked at places like Google, HRT, Citad…

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US-UK nuclear deal, and forensics for plastic pollution 33:50

12h ago33:50

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In the news podcast, the US and the UK have forged a long-term nuclear alliance - but what will it really deliver? We also examine a new study on whether smoking cannabis makes it harder to get pregnant. And we'll be hearing from a forensic scientist who is using detective work to rid our oceans of plastic. Like this podcast? Please help us by supp…

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20VC: Opendoor's CEO on The Greatest Turnaround in Tech | OpenAI and Oracle: How Can Either Afford to Do This | How Anthropic Could Lose 50% of Their Revenue Overnight | Replit Raises at $3BN | Figure ... 1:24:20

4d ago1:24:20

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AGENDA: 00:00 Opendoor's Potential and Market Valuation 03:32 Why Did Kaz Leave $300M on the Table to Join Opendoor 04:44 Why Does Kaz Believe OPEN Can Be a Good Business When the Market Doesn’t 06:34 How does Kaz Feel About OPEN Becoming a Meme Stock? 17:25 Kaz’s $0 Salary but $1BN Stock Based Compensation 23:41 Oracle and OpenAI Partnership: WTF …

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Four Pillars of Anti-Aging w/ Blair LaCorte, Anders Varner, Doug Larson, and Travis Mash #815 58:03

4h ago58:03

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Blair LaCorte is the Vice Chair of the Board of Directors at the Buck Institute for Research on Aging—the world’s first biomedical research institution dedicated solely to understanding aging and age-related diseases, and the largest independent scientific institute in the Bay Area. A seasoned leader and strategist, Blair has a track record of tran…

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A decade of detecting gravitational waves 35:54

18h ago35:54

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To celebrate 10 years since they were first detected, we're examining gravitational waves. What are they? And how do we find them? Like this podcast? Please help us by supporting the Naked ScientistsBy The Naked Scientists

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20VC: Mercor: From $1M to $500M in 17 Months: The Fastest Growing Company in the World | How to Think About Margins and Revenue Sustainability in AI | Why Evaluation Benchmarks in AI are BS Today with ... 1:01:16

7d ago1:01:16

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Brendan Foody is the Co-Founder and CEO @ Mercor, the fastest growing company in history. The company solves talent allocation in the AI economy and they have scaled from $1M to $500M in revenue in just 17 months. With a rumoured new funding round pricing the company at a whopping $10BN, the company has the likes of Benchmark, Felicis, Emergence, a…

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20VC: Why AI SDRs are BS and Do Not Work | How to Use AI in Your Sales Team and Process to Win Today | What Skills Do All New Reps Need to Have in an AI First World with Amit Bendov, CEO @ Gong 1:06:20

10d ago1:06:20

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Amit Bendov is Co-Founder & CEO of Gong, the leading AI-sales platform. The company has raised over $600 million from some of the best in the world including Sequoia, Thrive, Salesforce and more. Gong has surpassed $300M in ARR, serves thousands of customers (including multiple Fortune 10s), and is valued at over $7BN. AGENDA: 00:00 – Why CRM Was A…

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Ancient Mars bacteria, and 'fugitive' methane leaks 35:10

13h ago35:10

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In this edition of The Naked Scientists, the strongest hint yet of life on Mars. Should we get excited? Or is it another red herring? Also ahead: The first new UK-wide study of babies in 25 years. We'll find out why it matters. Plus, an ancient lizard-like fossil is discovered on the coast of Devon. We'll uncover the significance... Like this podca…

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20VC: Musk's $TRN Pay Package Broken Down | Ramp Hits $1BN ARR and Brex Hits $700M: Who Wins | OpenAI's $10BN Secondary Sale | Atlassian Buys The Browser Company for $610M | ASML Lead Roun into Mistral ... 1:27:56

11d ago1:27:56

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AGENDA: [00:05] Musk’s $1 Trillion Pay Package: The Breakdown? [00:15] Scale, Windsurf: Are Founders Just Mercenaries Chasing Cash Today? [00:21] Ramp at $1B ARR, Brex at $700M — Is AI Causing All Boats To Rise? [00:26] Sierra at $100M ARR Worth $10B — Bubble or Brilliant Bet? [00:30] Kleiner Perkins Invests $100M into Anthropic at $183BN… WTF? [00…

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The Path to IFBB Pro w/ Aaron Starker, Anders Varner, Doug Larson, and Travis Mash #814 55:17

18m ago55:17

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Aaron Straker is a N.A.S.N. Licensed Primary Sports Nutritionist. He prefers a pragmatic approach to nutrition that focuses on simple food selection, the importance of nutrient density, and the importance of objectivity in dieting and reporting. Today on Barbell Shrugged we dive into Straker’s path to becoming and IFBB Pro. From injury, setbacks, d…

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Made in orbit: How to sustain life in space 34:33

13h ago34:33

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What does it take to build a society in space? Today on the Naked Scientists, we explore efforts to make microgravity amenable to humans; including how to harvest energy, make fresh food, and even birth the next generation of space explorers... Like this podcast? Please help us by supporting the Naked Scientists…

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Bio Bytes 44: AI to Bridge Biology and Medicine with Dr. Nima Aghaeepour 37:12

19h ago37:12

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Dr. Nima Aghaeepour, Professor at Stanford University, discusses the nuances of working with clinical data, ways predictive models can add value to physicians and drive behavioral change, and the process of spinning scientific ideas out into startups.

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20VC: ElevenLabs Hits $200M ARR: The Untold Story of Europe's Fastest Growing AI Startup | The Real Cost of AI from Talent to Data Centres | How US VCs are in a Different League to Europeans | The Future ... 1:14:06

14d ago1:14:06

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Mati Staniszewski is the Co-Founder and CEO of ElevenLabs, the world’s leading AI voice platform. Since launching in 2022, ElevenLabs has raised over $350M, most recently at a $3.3BN valuation, making it one of Europe’s fastest AI unicorns. The company counts Andreessen Horowitz, Nat Friedman, Daniel Gross, and Sequoia Capital among its backers. To…

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20Growth: Meta CMO Alex Schultz on How All Founders Have to Change Their Marketing Playbook in a World of AI | Is AI Plateauing, What it Means if China Wins the AI Race and Why Zuck is a Generational Leader ... 1:10:09

17d ago1:10:09

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Alex Schultz is the Chief Marketing Officer and VP of Analytics at Meta, where he has spent nearly two decades shaping the company’s growth and marketing strategy. He has been instrumental in scaling Facebook, Instagram, and WhatsApp to billions of users worldwide. Alex is is also the author of Click Here: The New Rules of Marketing, the definitive…

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Physiology Friday: [Brain Health] Science and Strategies for Optimizing Brain Health w/ Dan Garner, Anders Varner, Doug Larson, and Coach Travis Mash 49:24

4d ago49:24

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In today’s episode of Barbell Shrugged, we'll be discussing the various factors that impact brain health and exploring strategies for optimizing brain function. First, we'll be discussing the impact of exercise on brain health. Research has shown that regular exercise can help to improve brain function, enhance cognitive performance, and even reduc…

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Energy drinks curb, and biting back against beetles 35:23

4d ago35:23

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In this edition of The Naked Scientists: A new test to detect Alzheimer's disease long before symptoms first appear. Also, the study showing Earth can sequester only a tenth of the carbon we thought it could. And, how drones, traps and sniffer dogs are protecting the UK's timber industry from beetle attack... Like this podcast? Please help us by su…

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Episode 186: Mari Dezawa discusses her discovery of MUSE cells and the role of stem cells in regenerative medicine 47:19

5d ago47:19

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Today we have Dr. Mari Dezawa, one of the world’s leaders in stem-cell research and regenerative medicine. Mari is a pioneer in this emerging field and is known worldwide for her discovery of MUSE cells, a unique type of stem cell with exciting clinical potential. MUSE is short for Multilineage-Differentiating Stress-Enduring Cells. Mari is a profe…

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20VC: Anthropic Raises $13BN | Why Canva Will Not Direct List | OpenAI Buys Statsig for $1.1BN All Stock | Lovable Raising at $4BN + Vercel at $9BN: Justified or Not | Quarterly Results from SNOW, Mongo ... 1:14:22

18d ago1:14:22

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Agenda: 04:00 – Anthropic Raises $13BN: The Analysis? 19:00 – Is Zuck’s $14BN Scale bet the biggest blunder in AI? 27:00 – Lovable Raising at $4BN and Vercel at $9BN: Justified or Madness? 36:00 – Quarterly Results for Snowflake, Mongo, Okta, Zoom Skyrocket: Is B2B SaaS back from the dead? 48:00 – Is Jensen Huang right there will be $4TRN in AI gai…

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How to Eliminate Back Pain w/ Dr. Melissa Capurro, Anders Varner, Doug Larson, and Travis Mash #813 49:13

6d ago49:13

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Melissa is a performance physical therapist and is heavily involved in the CrossFit space as a healthcare provider, as well as an athlete. Melissa grew up in the Metropolitan New York area, but now resides in the Tampa Bay area. Upon graduating from PT school, Melissa started working in an outpatient orthopedic physical therapy practice, but was un…

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Bio Bytes 43 [BenchtoBedside Series]: Pediatric Cardiology and AI with Dr. Son Duong 29:58

7d ago29:58

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In this episode of BenchtoBedside, Dr. Son Duong, Assistant Professor of Pediatrics in the Division of Pediatric Cardiology at the Mount Sinai Kravis Children’s Heart Center and Icahn School of Medicine, discusses pediatric cardiology and the evolving role of AI within the speciality. He highlights how machine learning and AI tools can democratize …

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Is AI changing the way we think? 34:27

13d ago34:27

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In this edition of The Naked Scientists, from bogus scientific papers and misleading made-up "facts", to potentially curtailing our critical thinking, we look at the effect that mass adoption of AI might be having on the way we think, the decisions we make and the information we learn and act on... Like this podcast? Please help us by supporting th…

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20VC: Cohere Founder on How Cohere Compete with OpenAI and Anthropic $BNs | Why Counties Should Fund Their Own Models & the Need for Model Sovereignty | How Sam Altman Has Done a Disservice to AI with ... 1:07:50

21d ago1:07:50

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Nick Frosst is a Canadian AI researcher and entrepreneur, best known as co-founder of Cohere, the enterprise-focused LLM. Cohere has raised over $900 million, most recently a $500 million round, bringing its valuation to $6.8 billion. Under his leadership, Cohere hit $100M in ARR. Prior to founding Cohere, Nick was a researcher at Google Brain and …

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Physiology Friday: [Blood Work] High Performance Blood Chemistry w/ Dan Garner, Anders Varner, and Doug Larson 47:51

11d ago47:51

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In today’s episode of Barbell Shrugged Dan Garner dives into how you can start to analyze your yearly bloodwork for performance. Standard blood tests can be ordered around the globe, in every country, and are the gold standard for understanding basic health. The normal reference ranges, however, are not giving you the answers you are looking for wh…

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20Product: Why Most CPOs are Bad | Why You Do Not Need PMs in a World of AI | Why the Design Stage is Dead and How to Use Vibe Coding to Replace It | The Three Roles All Founders End Up Firing on Repeat ... 53:48

23d ago53:48

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Jason James is the Co-Founder of Tezi and one of the leading product minds in the valley. Prior to Tezi, Jason was the VP Product at Instacart and before that was Head of Product and Design at Thumbtack. AGENDA: 00:00 Product lessons scaling Instacart to $40B – what really moves the needle 02:15 Why “quick optimizations” won’t build billion-dollar …

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First pig lung transplant, and the origins of dark energy 33:39

11d ago33:39

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Today on the Naked Scientists: a pig lung is transplanted into a man in China, but what was the outcome? Also, scientists have a theory for the origins of Dark Energy - and it makes sense that a black hole might be the source! And, why the dawn chorus is starting earlier and finishing later these days: what's getting into wildlife? Like this podcas…

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20VC: Anthropic's $10BN Round | Klarna's IPO Broken Down | Inside a16z's 72 Deal Seed Investment Machine | Martin Casado: Is Consensus Investing the Only Game | Why Satya is Chatting S*** on SaaS Apps ... 1:11:40

25d ago1:11:40

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AGENDA: 00:00 – Marc Benioff vs Snowflake, Databricks & Palantir: Who Wins the Data Cloud War? 05:10 – Does Benioff Feel The Need to Buy AI Talent Like Zuck Is? 09:00 – What Salesforce has Learned From Palantir on Forward Deployed Engineers? 18:00 – Will SaaS apps disappear in an AI world? Why Satya is Chatting S*** 23:40 – Are SDRs really screwe…

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Hard Truths from a Lifetime of Training w/ Bryan Boorstein, Anders Varner, Doug Larson, and Travis Mash #812 59:48

20d ago59:48

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Bryan Boorstein has 24 years of training and over 13 years of coaching experience. A 3-time CrossFit Regional athlete and CrossFit Games coach, Bryan holds a Bachelor of Science from JMU (2006) and certifications in CrossFit L-2 and Mobility. As the owner and founder of Evolved Training Systems and Paragon Training Methods, he’s a trusted name in f…

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What can we do about hair loss? 36:32

16d ago36:32

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In this edition of The Naked Scientists, we look at the science of hair, why we suffer hair loss, treatments that can slow hair loss, whether wigs are any good, and what happens during a hair transplant? Like this podcast? Please help us by supporting the Naked ScientistsBy The Naked Scientists

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20VC: Do Margins Matter in AI? | Is Defensibility Gone For Good? | Is Vertical SaaS Dead in a World of AI | What SaaS Rules Are BS and No Longer Apply in a World of AI | The Future of Venture: Why Chanel ... 1:21:03

28d ago1:21:03

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Byron Deeter is a Partner at Bessemer Venture Partners, and one of the most renowned SaaS investors. Byron has led 19 unicorn investments, including IPO successes like ServiceTitan, Procore, Twilio, Box, Gainsight, Intercom, DocuSign, SendGrid. His portfolio includes eight companies that have gone public. Insane. Agenda: 00:00 – Why are the stakes …

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Physiology Friday: The Rhythm of Rest: Unlocking Sleep Potential Naturally w/ Dr. Chris Perry, Anders Varner, Doug Larson, and Travis Mash 54:16

18d ago54:16

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Dr. Christopher A. Perry, an Assistant Professor at Eastern Kentucky University, began his fitness journey at Penn State University, where he developed a robust background in Strength & Conditioning leading to 17 years in the industry to date. His academic path, leading through a PhD at Arizona State University, deepened his expertise in Exercise S…

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Apple wins privacy row, and microbes dictate chocolate taste 34:40

18d ago34:40

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In this edition of The Naked Scientists, Apple locked horns with the UK government who were demanding a security back door through the company's encryption. What was the outcome? Also, scientists discover the secret to the tastiest chocolate - it's all down to microbes. And, archaeologists uncover the earliest evidence yet of our ancestors using st…

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20VC: Databricks at $100BN | Chamath’s SPAC Revival: Peak Mania? | OpenAI Staff Cash Out Billions & Sam Altman Will Spend Trillions | CoreWeave’s $11B Debt Bet & Nubank’s $2.5B Profit Shocker 1:27:58

1M ago1:27:58

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Agenda: 00:00 – Databricks hits $100B: Bubble or just the beginning? 03:15 – Is Databricks actually undervalued at 25x revenue? 07:40 – Are we on the verge of the biggest IPO wave ever? 11:30 – Can Andreessen’s Databricks bet return $30B+? 18:10 – Who really gets rich when mega-unicorns IPO? 19:30 – Is the return of Chamath’s SPACs the ultimate bub…

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The Truth About Energy Drinks w/ Flavia Pereira, Anders Varner, Doug Larson, and Travis Mash #811 47:06

20d ago47:06

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Flavia is a passionate CISSN nutrition coach, full-time Exercise & Sport Science faculty member, and beach volleyball strength & nutrition coach. She has been teaching and coaching for the past 18 years. She graduated with a B.S. and M.S. in Kinesiology - Exercise Science and is pursuing her Ph.D. in Health & Human Performance. Flavia is part of th…

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What Niger's AMR outbreak means for the world 31:03

21d ago31:03

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In this edition of The Naked Scientists, why we need to pay closer attention to antimicrobial resistance in some of the world's poorest nations... Like this podcast? Please help us by supporting the Naked ScientistsBy The Naked Scientists

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20VC: Lovable CEO Anton Osika on $120M in ARR in 7 Months | The Honest Truth About Defensibility and Unit Economics for AI Startups | The State of Foundation Models: Long Grok, Short OpenAI, Why | Replit ... 1:08:48

1M ago1:08:48

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Anton Osika is the Co-Founder and CEO @ Lovable, the fastest growing company on the planet. In just 7 months, they have scaled from $0 to $120M in ARR. They have raised over $200M in funding from some of the best including Accel, Creandum and 20VC. Their latest round priced the company at a whopping $2BN. Agenda for Today: 00:00 – Is AI an Arms Rac…

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Physiology Friday: How to Build a Killer Cardiovascular System w/ Dr. Mike T. Nelson, Anders Varner, Doug Larson, and Travis Mash 52:24

1M ago52:24

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In today’s episode of Barbell Shrugged, Anders Varner, Doug Larson, and Travis sit down with Anders coach, Dr. Mike T. Nelson. For those that have followed the show, you know Anders has been in pursuit of running a sub-6 minute mile at the age of 40. Dr. Nelson is the coach Anders hired to help with that goal. In this episode the crew walks through…

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20VC: 15 Term Sheets in 7 Days and Choosing Benchmark | Harvey vs Legora: Who Wins Legal and How to Play When You Have $600M Less Funding | Are AI Models Plateauing Today | Building a 9-9-6 Culture From ... 1:20:48

1M ago1:20:48

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Max Junestrand is the Co-Founder and CEO @ Legora, the collaborative AI powering the next generation of lawyers. Now this is an insane story for many reasons; first, Max turned down a multi-million dollar career in gaming to build Legora. Second, he has raised from the best of the best including Benchmark and IVP. Third, he has scaled the firm with…

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Decoding our inner voice, and hunting for life on Mars 36:35

1M ago36:35

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In this edition of The Naked Scientists: the scientists who think they can decode the thoughts we hear in our heads. Also ahead: do ultra-processed foods make it much harder to lose weight? Plus, we hear from the PhD student who is aiding the search for life on Mars... Like this podcast? Please help us by supporting the Naked Scientists…

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20VC: GPT5: Sam Altman's Masterplan or a Gift To Anthropic | Palantir & Shopify Crush Earnings | Monday & Datadog Perform But Hit Hard by Wall St | Should Perplexity Buy Chrome for $34.5BN | 1:22:01

1M ago1:22:01

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AGENDA: 00:04 – Was GPT-5 the Biggest AI Letdown Yet? 00:17 – Is OpenAI’s Real Target Anthropic’s $6B Revenue? 00:22 – Why Anthropic Might Secretly Be Worried 00:28 – The Hidden Business Strategy Behind OpenAI’s “Underwhelming” Launch 00:32 – Should Perplexity Really Try to Buy Chrome for $34.5B? 00:35 – The $3B N8N Deal: Genius Bet or Bubble FOMO?…

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When to Make Changes to Your Training w/ Anders Varner, Doug Larson, and Travis Mash #810 51:57

27d ago51:57

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The crew breaks down how to know when it’s time to pivot your training. From bodybuilding and Olympic lifting to CrossFit, strongman, and martial arts, they share what decades under the bar have taught them about adapting for longevity, avoiding injury, and keeping fitness enjoyable. In this episode, you will learn: How to recognize when your train…

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Alexey Lugovskoy Shares Decades of Experience in Starting Out and Founding Companies 47:23

28d ago47:23

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August 12, 2025 | Diagonal Therapeutics founder and CEO Alexey Lugovskoy discusses the key lessons learned over his illustrious career, starting from his childhood in the Soviet Union to founding his own company, Diagonal Therapeutics. With host Tariq Ghayur, Lugovskoy shares insights gained from working with organizations of different sizes, takin…

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'Three-parent babies' prevent inherited genetic condition 26:56

28d ago26:56

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James Tytko explores the science behind 'three-parent' embryos: the incredible medical procedure that prevents children from inheriting incurable mitochondrial diseases. Like this podcast? Please help us by supporting the Naked ScientistsBy The Naked Scientists

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20VC: Figma, Scale, Wiz: Inside Index's Decacorn Factory | Decision-Making, Investment Process, Biggest Lessons, Biggest Misses | Why Gross Margin is a Fallacy at Seed | Never Turn Down a Deal on Price ... 1:19:50

1M ago1:19:50

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Martin Mignot is a Partner at Index Ventures, the best-performing fund in the world right now. In the last three months, they have sold Wiz for $ 32 billion, sold Scale for $14.9 billion, and IPO'd Figma as the largest investor. In addition to this, they are the largest or second-largest shareholders in Roblox, Revolut, Adyen and Datadog. Agenda fo…

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Physiology Friday: [Immune System] Why Optimal Nutrition Starts with the Immune System w/ Anders Varner, Doug Larson, Coach Travis Mash and Dan Garner 56:46

1M ago56:46

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In this Episode of Barbell Shrugged: What is the immune system Why the immune system is responsible for building muscle How gut health impacts the immune system Understanding recovery and its impact on the immune system How to optimize your immune system for performance Visit https://rapidhealthoptimization.com Connect with our guests: Anders Varne…

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Medicinal microbes for kidney stones, and musky mice 31:24

1M ago31:24

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In the news, why a dose of bacteria might be the solution to combating kidney stones. What tooth enamel tells us about the lives and diets of dinosaurs. And what the world's most abundant insects can teach robots... Like this podcast? Please help us by supporting the Naked ScientistsBy The Naked Scientists

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20VC: The $BN Greenoaks Backed Protein Bar | Hitting $100M Revenues in David's First Year: Lessons & Mistakes | $0 to $600M: The Untold RXBAR Story | Product-Market-Fit, Pricing, Branding: What Every Founder ... 1:06:15

2M ago1:06:15

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Peter Rahal is the Co‑Founder & CEO of David Protein, the highest protein‑to‑calorie ratio for any protein bar on the market. Peter has raised over $85M from Greenoaks, Dr. Peter Attia and Dr. Andrew Huberman with the latest round valuing the company at $725 million. The company is poised for over $100 million in first‑year revenue. Formerly, Peter…

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20VC: Figma's 250% Pop - The Greatest IPO Mispricing Ever | Meta and Microsoft Blowout Quarters: Broken Down | Cognition Raises at $15BN and Ramp at $22BN | CRV Downsizing and What It Means for LPs and ... 1:20:30

2M ago1:20:30

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Agenda: 00:00 – The Worst IPO Mis-Pricing Ever: What Really Happened at Figma 02:30 – Fidelity vs Founders: How Important is Fidelity When Going Public 07:00 – Why Founders Secretly Want a Pop, Even If It Makes Them Look Stupid 10:15 – The Truth Behind the $3B Figma "Left on the Table" 14:00 – Direct Listings vs IPOs: Should Figma Have Gone Direct …