Conversations with scientists at the forefront of brain research. Hosted by neuroscientist Mark Mattson.
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Mark Mattson Podcasts
A podcast about health, science, nutrition, aging, and fitness.
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We’re a team of doctors with a combined 100 years of experience and a passion for helping patients find long-term vitality using our new approach to medicine. Instead of just trying to lengthen your lifespan, we aim to lengthen your healthspan.
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This podcast series is built to bring science and research from the endurance sports industry. These may help you learn and implement these in your training, recovery, and nutrition journey. We invite coaches, exercise scientists, researchers, nutritionists, doctors, and inspiring athletes to come and share their knowledge and stories with us. So, whether you're just getting started with running or want to get better at it, this podcast is for you!
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“Scaling Clean" is an insightful podcast for cleantech CEOs, investors and the people who advise them. Each show, host Mike Casey brings you a deeper look into the minds of influential leaders working to create a new clean economy.
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A zany, scripted, dark comedy that explores the bystander effect - a social psychological theory that states individuals are less likely to offer help to a victim when in the presence of other people. Every season - new story, new Bystanders. Created by: Ash Lendzion and Jaclyn Hales Executive Produced by: Black Label Media, Heather Morris, Ash Lendzion, Jaclyn Hales, Nick Blair Wilfong, and Marilee Stafford Directed by: Jaclyn Hales and Ash Lendzion Written by: Jaclyn Hales, Ash Lendzion, N ...
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In a world brimming with groundbreaking discoveries and technological advancements in medicine and science, equitable access to life-saving cures and treatments remains a pressing concern. Join us on a riveting journey through my podcast series, where we delve into the heart of pioneering research, innovative breakthroughs, and the tireless efforts of scientists and doctors to make healthcare accessible and affordable for all. Through thought-provoking conversations with leading experts, pas ...
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EP 236 : Intermittent fasting with Prof. Mark Mattson
1:16:21
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1:16:21In this episode, we are joined by Prof. Mark Mattson, adjunct professor of neuroscience at Johns Hopkins School of Medicine. He is also the former chief of the Laboratory of Neurosciences. Mark is a leading voice in intermittent fasting. Vikas and Mark discussed the impacts of Intermittent fasting on brain function, the types of intermittent fastin…
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Ai Yamamoto: "ALFY" Cleanses Neurons of Pathological Proteins to Counteract Degenerative Diseases
1:12:11
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1:12:11A shared feature of neurodegenerative disorders is accumulation of aggregated proteins within neurons: Tau in Alzheimer's disease; alpha-synuclein in Parkinson's disease; huntingtin in Huntington's disease; and TDP43 in amyotrophic lateral sclerosis. In this episode Ai Yamamoto – an Associate Professor Neurology at Columbia University – talks about…
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EP 237 : Masterclass on Brain Stroke with Dr. Pradyumna J. Oak, Senior Neurologist and Director of Neurology at Nanavati Super Speciality Hospital, Mumbai
28:57
28:57
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28:57In this episode, we are joined by Dr. Pradyumna J. Oak. Dr. Oak is a Senior Neurologist and Director of Neurology at Nanavati Super Speciality Hospital, Mumbai. His extensive experience in stroke management and neurocritical care makes him a perfect expert to speak on brain stroke. Vikas & Dr. Oak discussed causes, diagnosis, risk factors, importan…
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Marco Capogrosso – Spinal Cord Stimulation for Recovery of Function After Stroke or Trauma
1:03:16
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1:03:16Remarkable advances are being made in the development and clinical applications of stimulation devices that enable recovery of motor function in patients who have suffered a spinal cord injury, a stroke, and even those with rare disabling genetic disorders. At the forefront of this research is Marco Capogrosso at the University of Pittsburgh. He ha…
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#66 – Dr. William Li | Angiogenesis & “Food as Medicine” Authority | President of the Angiogenesis Foundation
1:06:36
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1:06:36Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. William Li, a pioneering physician-scientist, bestselling author, and global leader in the “food as medicine” movement. Dr. Li is the President and Medical Director of the Angiogenesis Foundation, where his groundbreaking work has redefined how we understand f…
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Scott Ayton: Iron, Brain Health, Parkinson's and Alzheimer's Diseases – A Delicate Balance
1:15:26
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1:15:26Dietary iron is essential for health as it plays important roles in the ability of hemoglobin to carry oxygen throughout the body and brain. In addition, iron is involved in various functions in cells including the generation of ATP in mitochondria and DNA synthesis. The vast majority of iron is bound to proteins such as ferritin and heme. However,…
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EP 235 : (Hindi Podcast) Functions of Creatine & Its Supplementation for Performance
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20:11We discuss Creatine today! Creatine is one of the most researched supplements and yet it carries several myths. Today, we discuss the keys functions of Creatine, dosage of supplementation and any possible side effects. This topic is in Hindi and is intended to cover a broader audience. The key topics covered are:* Creatine & its roles in the human …
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#107 How To Cure Insomnia & Fall Asleep Fast | Dr. Michael Grandner
3:44:55
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3:44:55Get access to more than 70 Ask Me Anything episodes with Dr. Rhonda Patrick when you sign up as a FoundMyFitness Premium Member Chronic insomnia and untreated sleep apnea profoundly accelerate cognitive decline, impair performance, and diminish resilience. In this episode, Dr. Michael Grandner outlines practical, scientifically validated interventi…
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Erik Musiek: Brain Cell Circadian Clock Proteins in Neuroplasticity, Aging, and Alzheimer's Disease
1:12:00
1:12:00
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1:12:00Health depends upon proper regulation of circadian rhythms of cell and organ functions. Disruption of circadian rhythms has detrimental consequences for brain function and resilience and abnormal circadian rhythms are a common feature of Alzheimer's disease. In this episode neurology professor Erik Musiek talks about the roles of specific circadian…
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EP 234 : Exploring the Relationship between Physical activity & Mental Health with Stuart Biddle
45:17
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45:17In this episode, we are joined by Stuart Biddle. Stuart Biddle is a professor of Physical Activity and Health. His current research interests centre on sedentary behaviour and physical activity, behaviour change strategies, and mental health outcomes. Vikas and Stuart discussed the relationship between physical activity and mental health. We also d…
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Georgia Hodes: Sex Differences in Responses to Stress and Vulnerability to Neurological Disorders
1:11:08
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1:11:08Chronic uncontrolled stress is a risk factor for many different diseases including mental and neurodegenerative disorders. The effects of such stress on the brain differ considerably between females and males. However, the vast majority of preclinical studies in animal models have included only males which in some cases has resulted in therapeutic …
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EP 233 : The Growth Of Running With Alessio Punzi, Head of Road Running and Mass Participation at the World Athletics
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51:35In this episode, we are joined by Alessio Punzi, the head of Road Running and Mass Participation at World Athletics. Vikas and Alessio discussed the growth of running events globally and in India, categories of races & how race organizers can take their race to the next level. The key points discussed in the conversation are : The role of World Ath…
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#106 How To Increase Your Testosterone Levels Naturally | Derek from MPMD
3:16:39
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3:16:39Get access to more than 70 Ask Me Anything episodes with Dr. Rhonda Patrick when you sign up as a FoundMyFitness Premium Member When testosterone runs low, libido isn't the only casualty—muscle mass drops, fat accumulates, insulin resistance rises, and motivation declines. In this episode, Derek from More Plates More Dates highlights common pitfall…
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Marian Joëls and Ron de Kloet: How the Brain Responds to Stress in Health and Mental Disorders
1:14:54
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1:14:54In stressful situations the brain communicates with the adrenal glands stimulating them to release adrenaline and cortisol. This stress responsive neuroendocrine system plays important adaptive roles by regulating energy metabolism, attention, and learning and memory. However, without a recovery period chronic uncontrolled stress such as psychosoci…
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EP 232 : How to become the youngest female Ironman finisher - with Renee Noronha
31:32
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31:32Renee, now 19Y old, talks about her journey to becoming the youngest female Ironman finisher. She outlines how she prioritizes her sport interests along with her studies. Renee completed her first Ironman in New Zealand at the age of 18 years and recently also participated in the Ironman Hamburg European Championship. Vikas and Renee discussed how …
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EP 231 : Cardiac screening, diagnosis and sudden cardiac incidents during endurance events - Dr. Jonathan Ho-Youn Kim
51:20
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51:20In this episode, we are joined by Dr. Jonathan Ho-Youn Kim, who is a professor of medicine & the founding director of sports cardiology at Emory University. His expertise enables him to serve as an advisor to top athletes in the NBA and NFL. Vikas and Dr. Jonathan discussed sudden cardiac incidents that happen during racing. Here are the key pointe…
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Josh Helman: Multipronged Approaches for Preventing and Treating Alzheimer's Dementia
59:38
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59:38Clearly demonstrated as being effective for cardiovascular disease, lifestyle medicine is becoming an important discipline for the prevention and treatment of age-related brain disorders including Alzheimer's and Parkinson's diseases. In this episode I talk with Dr. Josh Helman about his experience working with patients at lifestyle medicine center…
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#65 - Dr. Mark Mattson | Neuroscience, Intermittent Fasting, and Brain Health
1:06:48
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1:06:48Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Mark Mattson, one of the world’s leading neuroscientists and a pioneer in the study of aging, brain health, and neurodegenerative diseases. Dr. Mattson is Chief of the Laboratory of Neurosciences at the National Institute on Aging and Professor of Neuroscience…
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Grace (Beth) Stutzmann: Pivotal Role for Calcium in Brain Aging and Alzheimer's Disease
53:14
53:14
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53:14The calcium ion controls neuronal network activity, synapse function and synaptic plasticity, and is a fundamental mediator of learning and memory. With aging and much more so in Alzheimer's disease the ability of neurons to properly regulate their intracellular calcium levels becomes compromised. Evidence from human and laboratory animal studies h…
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EP 230 : History of Hyderabad Runners and of NMDC Hyderabad Marathon with Rajesh Vetcha
52:00
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52:00Hyderabad Runners Society and Hyderabad Marathon hold a very special place in our hearts. Today, we sit down with Rajesh Vetcha - the founder of the Hyderabad Runners Society and the race director of the NMDC Hyderabad Marathon. In the conversation, we discuss how the Hyderabad Runners Society was formed, its growth, and how it has reached its popu…
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EP 229 : Pollution, Its impact on cardiovascular health and running performances
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49:49
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49:49In this episode, we are joined by Dr. Aruni Bhatnagar, who is a scientist and a professor at the university of Louisville. He is also an expert in environmental cardiology. Vikas and Dr. Bhatnagar discussed pollution, its impact on running and overall health. The key points discussed during the conversation are: - the importance of a good cardiovas…
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Andrew Dillin – Stress and Aging: Mitochondria are Hubs of Information Flow in and Between Cells
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49:00
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49:00Long believed to function only as the cell's powerhouse research is revealing that mitochondria actively control a cell's response to various types of stress. Even more amazingly mitochondria send stress-related signals between cells. In this episode UC Berkeley Professor Andy Dillin has made major advances in understanding basic mechanisms of agin…
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#105 Exogenous ketones, my coffee protocol, and supplements for blood sugar regulation (Premium Member Q&A July 2025)
33:05
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33:05Become a FoundMyFitness Premium Member to access the full episode In this special episode, you'll get an exclusive 30-minute preview of my latest Ask Me Anything (AMA) session, normally reserved for FoundMyFitness Premium Members. Each month, Premium Members join me live to receive direct answers to their most pressing questions on nutrition, suppl…
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EP 228 : Understanding Protein and Protein Consumption (In Hindi)
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36:42We have been focusing on a number of important topics that require detailed attention to it. In this episode, I discuss the basics of protein, its key functions and the consumption guidelines. You will learn the sources of protein, how and when to consume protein and is it harmful to you at any stage. You will also understand more about how vegetar…
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Marc Freeman – How Astrocytes Control Neural Circuits in Brain Development, Plasticity, and Disease
1:18:41
1:18:41
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1:18:41While neurons and the circuits the form have been the major focus of brain research the human brain contains at least as many cells that are not neurons of which astrocytes are by far the most abundant. During the past decade there have been numerous studies that reveal novel and very active roles for astrocytes in regulating the growth of neurons,…
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In this episode of Scaling Clean, we talk with Chad Farrell, CEO of Encore Renewable Energy. Unlike our previous guests, Chad is leading his first company — one he founded nearly 15 years ago. Encore develops community‑scale renewable energy projects, often on reclaimed industrial land, giving Chad unique lessons to share with first‑time cleantech …
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In this episode of Scaling Clean, we’re joined by Abby Hopper, President and CEO of the Solar Energy Industries Association (SEIA). A lawyer by training and veteran of major regulatory roles, Abby has led SEIA through pivotal years for the U.S. solar industry and brings unique insights on guiding teams through complex challenges. View transcript: h…
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Episode 2 of Scaling Clean features Robert E. Fishman, veteran CEO of three energy companies with experience in renewables, fossil fuels, and nuclear. Bob shares thoughtful insights on leadership and offers valuable lessons on assembling and maintaining strong executive teams. About Tigercomm: Tigercomm is top U.S. cleantech PR firm agency helping …
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Episode 3 of Scaling Clean features Mark Bassett, former CEO of Hemlock Semiconductor. With a Ph.D. in Chemical Engineering and a career spanning Dow Chemical and Hemlock, Mark shares insights on leading technical manufacturing companies, including driving sales growth during the COVID recession. About Tigercomm Tigercomm is top U.S. marketing comm…
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In this episode of Scaling Clean, we’re joined by Brad Mattson — often called a ‘Silicon Valley Legend’ for taking two companies from garage startups to Nasdaq. He’s also been a VC and led two clean economy companies, bringing decades of wisdom to our conversation. About Tigercomm Tigercomm is top U.S. marketing communications and public affairs fi…
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EP 227: (Hindi Podcast) The journey to the Ironman and Comrades with Mr. Vishvas Mote, Deputy Municipal Commissioner, BMC
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1:25:09Our guest for this episode is Mr. Vishvas Mote, the Deputy Municipal Commissioner, BMC and a fitness enthusiast who has completed a host of marathons, the iconic Comrades Marathon and the ‘Ironman Italy Emilia Romagna’ triathlon. In our conversation, we discuss Mr. Mote’s childhood, his education, upbringing and his journey to becoming a public ser…
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Polina Shichkova: Metabolic and Biophysical Modeling of Breakdown and Repair of the Aging Brain
1:03:05
1:03:05
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1:03:05Because neurons in the brain are electrically excitable and active 24/7 the brain consumes relatively large amounts of energy and must adapt to varying demands on its neural networks. The cellular and molecular complexity of the brain presents a major challenge for understanding not only its second-by-second function but also how neural networks ar…
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EP 226: (Hindi Podcast) Energy and Energy Gels
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21:07This podcast is great for someone wanting to understand the role of energy and strategies to fuel the long runs or racing events. If you are looking to plan your long runs and fuel appropriately, this podcast is for you. Vikas talks about the role of energy and of the energy sources. If you would like to learn the basics of energy, its sources and …
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Corinde Wiers: The Potential of Ketone-Based Interventions for the Treatment of Addiction
1:07:26
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1:07:26Research on substance use disorders has largely focused on understanding the key neural circuits and neurotransmitter systems that are altered, and on behavioral and pharmacological interventions. However, emerging research findings suggest that alcohol use disorder (AUD) is associated with alterations in energy metabolism and can accelerate brain …
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#64 - Dr. Yanina Pepino | The Neuroscience of Taste, Sweeteners, and Metabolic Health
1:28:24
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1:28:24Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they interview Dr. Yanina Pepino, a renowned professor of Ingestive Behavior at the University of Illinois. With a background in medicine and a research trajectory that spans Washington University’s Center for Human Nutrition to her current work in sensory biology, Dr. Pepino br…
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#104 Dr. Ben Bikman: How To Reverse Insulin Resistance Through Diet, Exercise, & Sleep
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3:01:02Get access to 130 episodes of my premium podcast, The Aliquot, as a FoundMyFitness Premium Member Insulin resistance silently shapes the trajectory of nearly every major chronic disease, yet it's often overlooked until blood sugar abnormalities become obvious. In this episode, Dr. Ben Bikman exposes the dietary culprits that drive metabolic dysfunc…
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Henning Fenselau – Neural Circuits Controlling Appetite and Energy Metabolism and GLP-1 Actions
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56:52Appetite (hunger and satiety) is controlled by neural circuits in the brain – particularly in the hypothalamus – and their reciprocal connections to peripheral organs involved in energy metabolism (gut and liver). Understanding the structural organization of these circuits (their synaptic connections) and their neurochemistry (particularly which ne…
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EP 225 : Sam Scott explains diabetes, running and nutrition
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49:38In this episode, we were in conversation with Sam Scott, author, researcher and entrepreneur driven by a passion to help people, especially athletes, with diabetes. Sam Scott takes us through the basics of diabetes, what it is, how does diabetes present itself in the body, what is type 1 and type 2 diabetes, what could be the probable causes of dia…
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#63 - Dr. Dominic D'Agostino | Advancing Metabolic Therapies Through Ketosis and Resilience Research
1:11:35
1:11:35
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1:11:35Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they speak with Dr. Dominic D’Agostino, Associate Professor at the University of South Florida and research scientist at the Institute for Human and Machine Cognition (IHMC). Renowned for his work on metabolic therapies, Dr. D’Agostino has led pioneering research into how nutrit…
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Tessa Montague: Disappearing Act - How the Brain Controls Camouflage in Cuttlefish and Octopuses
1:09:01
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1:09:01One of the most remarkable feats of biological 'wizardry' in the animal kingdom is the ability of some cephalopods (octopuses, squids, and cuttlefish) to rapidly change the color, patterning, and texture of their skin so as to blend in with their background. They accomplish these feats through the linking of neural circuits in the visual system and…
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EP 224 : Coach Ron Mann talks about John Korir's journey to becoming the Boston Marathon champion
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49:50In this episode, we were in conversation with Ron Mann, a distinguished coach who has been and still is a guiding force to some of the fastest long distance runners in the world. Coach Ron takes us through his journey of training the Korir brothers, Wesley and John, who went on to win the Boston Marathon in 2012 and 2025 respectively. Coach Ron als…
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Jonathan Long: Lactate-Phe and Ketone-Phe: Exerkines and Fastokines for Brain Health and Plasticity?
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1:02:26During vigorous exercise lactic acid (lactate) levels increase in the blood and during fasting and extended exercise the levels of the ketone BHB (b-hydroxybutyrate) increase. In this episode I talk with Stanford University professor Jonathan Long about his recent discovery that lactate and BHB in the blood are bound to the amino acid phenylalanine…
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EP 223: Understanding the significance of VO2Max
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52:18In this episode, we were in conversation with Brady Holmer who has majored in Applied Physiology and Kinesiology from the University of Florida and is a long distance runner himself. This conversation dives into understanding the significance of VO2Max for athletes as well as the general population. How to find out your VO2Max score, how to improve…
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Carlos Matute: Brain White Matter in Health, Endurance Exercise, and Disease
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1:17:20White matter consists of bundles of long axons that convey information between neural circuits between different brain regions within and between brain hemispheres. These long axons are wrapped with many layers of lipid-rich membranes of oligodendrocytes (a type of glial cell) and it is this 'insulation' that enables rapid propagation of signals ov…
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#62 - Dr. Jens Juul Holst | Discovering the Hormone That Changed Metabolic Medicine
1:04:38
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1:04:38Send us a text Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they speak with Dr. Jens Juul Holst, the renowned Danish physiologist and co-discoverer of GLP-1 (glucagon-like peptide-1), one of the most significant hormones in metabolic disease research. A professor of medical physiology at the University of Copenhagen and former scientific…
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#103 A Deep Dive on Using Coffee For Health & Longevity (Full Guide & Research)
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48:49Get access to more than 120 episodes of my premium podcast, The Aliquot, as a FoundMyFitness Premium Member Coffee is one of the most powerful longevity tools we have, potentially reducing epigenetic age by up to one year in regular coffee drinkers, but its effectiveness hinges entirely on how you brew it. In this episode, I outline precisely how c…
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EP 222 : Insights from Daniel Vaz on how to become a better runner
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49:19In this episode, we were in conversation with Daniel Vaz, a long distance runner and a Certified Strength & Conditioning Specialist (CSCS) from the National Strength Conditioning Association (NSCA), USA. In our conversation, we dive into Dan’s journey as a runner, his self experimentation with training techniques, how to progress from being a begin…
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Michael Kreutz: Amazing Nanomachines in Synapses that Keep Brains Healthy and Wise
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1:01:28Michael Kreutz is Head of the Neuroplasticity Research Group at the Leibniz Institute for Neurobiology in Magdeburg Germany. Using powerful high resolution microscopy and molecular biology tools his laboratory has shown that autophagy occurs within synapses. Synaptic autophagy is stimulated by neural network activity and is critical for their maint…
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EP 221 : Significance of Physiotherapy in Running
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53:08In this episode, we are in conversation with renowned sports scientist and physiotherapist, Dr. Nikhil Latey. Dr. Latey has been on the Indian Olympic Team as a physiotherapist, tending to elite athletes and helping them enhance their performance. In this conversation, we discuss what physiotherapy essentially is, how it can improve sporting perfor…
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Jordan Grafman: Neural Circuits of Religiosity: 'The Kingdom of God' is in the Prefrontal Cortex
1:11:17
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1:11:17Belief in supernatural agents and other religious myths arose as a means of 'explaining' the unknown and as a tool for social cohesion and hierarchical control of civilizations. Their religiosity is major feature of a 'believers' self identity as well as their group identity. Compelling evidence from multiple types of studies have revealed the neur…
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