Research on substance use disorders has largely focused on understanding the key neural circuits and neurotransmitter systems that are altered, and on behavioral and pharmacological interventions. However, emerging research findings suggest that alcohol use disorder (AUD) is associated with alterations in energy metabolism and can accelerate brain aging. In this episode I talk with Dr. Corinde Wiers about substance use disorders with a focus on her recent clinical trials which show that ketone (b-hydroxybutyrate) supplementation can reduce craving for alcohol in people with AUD and can reduce alcohol withdrawal symptoms. We discuss the potential mechanisms that may explain the efficacy of ketone supplementation – and interventions that elevate endogenous ketone production (fasting, exercise, and ketogenic diets) – in AUD. Whether or not ketogenic interventions are beneficial for individuals with other addictions (opioids, cocaine, nicotine, gambling..) remains to be determined.

LINKS:

Dr. Wiers webpage at the University of Pennsylvania: https://www.med.upenn.edu/apps/faculty/index.php/g332/p9389303

Dr. Wiers’ publications discussed in this podcast:

https://pmc.ncbi.nlm.nih.gov/articles/PMC8034849/pdf/abf6780.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC8670944/pdf/fpsyt-12-781668.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC10901540/pdf/pyae009.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC10895037/pdf/fnut-11-1254341.pdf