Chronic uncontrolled stress is a risk factor for many different diseases including mental and neurodegenerative disorders. The effects of such stress on the brain differ considerably between females and males. However, the vast majority of preclinical studies in animal models have included only males which in some cases has resulted in therapeutic interventions that are less effective in females compared to males. In this episode Georgia Hodes talks about sex differences in the effects of stress on the brain and neuroendocrine systems and how these differences can influence disease processes and treatments.

LINKS

Prof. Hodes webpage at VT:

https://neuroscience.vt.edu/our-people/research-faculty/hodes-georgia.html

Review articles:

https://pmc.ncbi.nlm.nih.gov/articles/PMC10845083/pdf/CN-22-475.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC10189838/pdf/nihms-1896436.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC8630768/pdf/nihms-1528739.pdf