#62 - Dr. Jens Juul Holst | Discovering the Hormone That Changed Metabolic Medicine

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Join Dr. Sandra Cammarata and Dr. Giovanni Campanile as they speak with Dr. Jens Juul Holst, the renowned Danish physiologist and co-discoverer of GLP-1 (glucagon-like peptide-1), one of the most significant hormones in metabolic disease research. A professor of medical physiology at the University of Copenhagen and former scientific director at the Novo Nordisk Foundation Center for Basic Metabolic Research, Dr. Holst has spent decades unraveling the gut’s intricate role in glucose metabolism and appetite regulation.

In this interview, Dr. Holst reflects on his journey from surgical training to groundbreaking endocrinology, detailing how GLP-1 emerged as a therapeutic cornerstone in the treatment of type 2 diabetes and obesity. He explores its far-reaching effects—ranging from cardiovascular and neuroprotective benefits to appetite and weight regulation—and shares insight into the future of metabolic therapies, including combination treatments and oral delivery strategies.

With honors including the Banting Medal, the Canada Gairdner Award, and the Breakthrough Prize in Life Sciences, Dr. Holst’s work has helped transform the landscape of modern medicine. This episode offers a compelling look at the science behind GLP-1 and the global impact of one of the most important endocrine discoveries of our time.

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