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Episode 21.1 - Progesterone, Estrogen, and PMS - Deep Dive

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Manage episode 520397121 series 3672136
Content provided by Dr. Steven Presciutti | Biospark Health. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Dr. Steven Presciutti | Biospark Health or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

The biochemistry, mechanisms, and research the pharmaceutical industry doesn't want you understanding. This is the science behind why PMS isn't normal.

Biospark Health researchers Sarah Chen (metabolic biochemistry) and Marcus Thompson (evolutionary biology) dismantle every PMS myth with hard science and documented research.

This Isn't Theory. It's Biochemistry:

🔬 The Q10 Enzyme Catastrophe: For every degree your temperature drops below 98.6°F, enzyme function decreases exponentially. At 97°F your progesterone-synthesizing enzymes operate at 70% capacity. At 96.5°F? About 50%. This is why you can't make hormones.

🧬 The Pregnenolone Steal Explained: When chronic stress is high, your body literally steals the building block of progesterone to make cortisol instead. Every woman doing keto + fasting + CrossFit is forcing this hormonal catastrophe. The biochemistry is clear.

⚡ The Thyroid-Estrogen Vicious Cycle: Estrogen increases thyroid-binding proteins → less free T3 available → lower metabolism → impaired liver estrogen clearance → more estrogen dominance → worse thyroid suppression. Complete mechanistic breakdown of the trap.

🔥 The PUFA-Aromatase Connection: Polyunsaturated fats increase aromatase enzyme activity that converts testosterone to estrogen. PUFA half-life in tissue: 600-680 days. You're carrying years of estrogen-producing poison.

💊 Why Birth Control Destroys Metabolism: Synthetic progestins are NOT bioidentical progesterone. They suppress natural production, lower thyroid function, reduce body temperature, increase inflammation, and leave the underlying dysfunction untreated for years.

Complete Research Breakdown:

  • Dr. Katharina Dalton's progesterone-IQ studies (35-point IQ difference)
  • Ray Peat's estrogen-as-stress-hormone framework
  • Jay Feldman & Mike Fave on T3 suppression from low-carb diets
  • Endotoxin-aromatase activation pathways
  • The inflammatory prostaglandin cascade from PUFAs
  • Temperature-enzyme function Q10 coefficient studies

Practical Protocols with Exact Numbers: Temperature targets, calorie minimums, carb-to-protein ratios, supplement dosages, PUFA elimination strategy, raw carrot salad mechanism, timeline expectations month-by-month.

Who This Is For:

  • Women who want the deep science behind hormone optimization
  • Anyone told "PMS is just normal"
  • Practitioners who need to understand mechanisms
  • People who love biochemistry and want the complete picture
  • Anyone in our Women's Generational Health Program wanting to understand WHY

The Bottom Line: Birth control profits from your suffering. We profit from your understanding. This is the research-heavy breakdown that turns PMS from mystery into mechanism.

Transform Your Hormonal Health:

→ Women's Generational Health Program: biosparkhealth.com/generations

→ Metabolic Fertility Guide: biosparkhealth.com/fertility

Your PMS is a metabolic problem with a metabolic solution.

  continue reading

39 episodes

Artwork
iconShare
 
Manage episode 520397121 series 3672136
Content provided by Dr. Steven Presciutti | Biospark Health. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Dr. Steven Presciutti | Biospark Health or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

The biochemistry, mechanisms, and research the pharmaceutical industry doesn't want you understanding. This is the science behind why PMS isn't normal.

Biospark Health researchers Sarah Chen (metabolic biochemistry) and Marcus Thompson (evolutionary biology) dismantle every PMS myth with hard science and documented research.

This Isn't Theory. It's Biochemistry:

🔬 The Q10 Enzyme Catastrophe: For every degree your temperature drops below 98.6°F, enzyme function decreases exponentially. At 97°F your progesterone-synthesizing enzymes operate at 70% capacity. At 96.5°F? About 50%. This is why you can't make hormones.

🧬 The Pregnenolone Steal Explained: When chronic stress is high, your body literally steals the building block of progesterone to make cortisol instead. Every woman doing keto + fasting + CrossFit is forcing this hormonal catastrophe. The biochemistry is clear.

⚡ The Thyroid-Estrogen Vicious Cycle: Estrogen increases thyroid-binding proteins → less free T3 available → lower metabolism → impaired liver estrogen clearance → more estrogen dominance → worse thyroid suppression. Complete mechanistic breakdown of the trap.

🔥 The PUFA-Aromatase Connection: Polyunsaturated fats increase aromatase enzyme activity that converts testosterone to estrogen. PUFA half-life in tissue: 600-680 days. You're carrying years of estrogen-producing poison.

💊 Why Birth Control Destroys Metabolism: Synthetic progestins are NOT bioidentical progesterone. They suppress natural production, lower thyroid function, reduce body temperature, increase inflammation, and leave the underlying dysfunction untreated for years.

Complete Research Breakdown:

  • Dr. Katharina Dalton's progesterone-IQ studies (35-point IQ difference)
  • Ray Peat's estrogen-as-stress-hormone framework
  • Jay Feldman & Mike Fave on T3 suppression from low-carb diets
  • Endotoxin-aromatase activation pathways
  • The inflammatory prostaglandin cascade from PUFAs
  • Temperature-enzyme function Q10 coefficient studies

Practical Protocols with Exact Numbers: Temperature targets, calorie minimums, carb-to-protein ratios, supplement dosages, PUFA elimination strategy, raw carrot salad mechanism, timeline expectations month-by-month.

Who This Is For:

  • Women who want the deep science behind hormone optimization
  • Anyone told "PMS is just normal"
  • Practitioners who need to understand mechanisms
  • People who love biochemistry and want the complete picture
  • Anyone in our Women's Generational Health Program wanting to understand WHY

The Bottom Line: Birth control profits from your suffering. We profit from your understanding. This is the research-heavy breakdown that turns PMS from mystery into mechanism.

Transform Your Hormonal Health:

→ Women's Generational Health Program: biosparkhealth.com/generations

→ Metabolic Fertility Guide: biosparkhealth.com/fertility

Your PMS is a metabolic problem with a metabolic solution.

  continue reading

39 episodes

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