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Dr. Eric Verdin on the Effects of Therapeutic Plasma Exchange on Longevity

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Manage episode 504157454 series 2955924
Content provided by Gil Blander PhD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Gil Blander PhD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging. Eric discusses the science behind therapeutic plasma exchange (TPE) and its potential to slow biological aging in humans. The conversation explores findings from a recent clinical trial, including measurable age reversal using epigenetic clocks.
Eric explains how removing and replacing plasma can dilute pro-aging factors in the blood, a concept inspired by earlier animal studies on parabiosis. He also describes why rigorous, placebo-controlled human trials are crucial for validating longevity interventions and distinguishing the field from hype-driven wellness trends.
The episode also highlights how omics data, such as metabolomics and proteomics, are shaping a new era of precision aging research. Eric emphasizes the value of lifestyle interventions as a foundation and sees future opportunities in combining TPE with personalized strategies to extend healthspan.

Guest-at-a-Glance

šŸ’” Name: Dr. Eric Verdin

šŸ’” What they do: President and CEO

šŸ’” Company: Buck Institute for Research on Aging

šŸ’” Noteworthy: Physician-scientist pioneering human aging research through epigenetics, metabolism, and translational science.

šŸ’” Where to find him: LinkedIn

Episode highlights:

[00:00] Introduction to Longevity and Healthspan
[01:07] Meet Dr. Eric Verde: A Pioneer in Aging Research
[02:24] Exploring Therapeutic Plasma Exchange
[03:08] The Science Behind Heterochronic Parabiosis
[07:17] Clinical Trials and Methodologies
[12:58] The Role of Omics in Precision Medicine
[17:20] Epigenetic Clocks and Aging
[22:04] Therapeutic Plasma Exchange: Results and Implications
[26:22] Exploring Frequency and Efficacy of Treatments
[28:23] Biomarkers and Predictive Models
[31:33] Safety Profile and Side Effects
[33:28] Intrinsic Capacity and Aging Metrics
[36:58] Combining Treatments with Lifestyle Changes
[44:26] Future Directions and Recommendations
[49:08] Conclusion and Final Thoughts

We Appreciate You!
As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast
For science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

  continue reading

94 episodes

Artwork
iconShare
 
Manage episode 504157454 series 2955924
Content provided by Gil Blander PhD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Gil Blander PhD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging. Eric discusses the science behind therapeutic plasma exchange (TPE) and its potential to slow biological aging in humans. The conversation explores findings from a recent clinical trial, including measurable age reversal using epigenetic clocks.
Eric explains how removing and replacing plasma can dilute pro-aging factors in the blood, a concept inspired by earlier animal studies on parabiosis. He also describes why rigorous, placebo-controlled human trials are crucial for validating longevity interventions and distinguishing the field from hype-driven wellness trends.
The episode also highlights how omics data, such as metabolomics and proteomics, are shaping a new era of precision aging research. Eric emphasizes the value of lifestyle interventions as a foundation and sees future opportunities in combining TPE with personalized strategies to extend healthspan.

Guest-at-a-Glance

šŸ’” Name: Dr. Eric Verdin

šŸ’” What they do: President and CEO

šŸ’” Company: Buck Institute for Research on Aging

šŸ’” Noteworthy: Physician-scientist pioneering human aging research through epigenetics, metabolism, and translational science.

šŸ’” Where to find him: LinkedIn

Episode highlights:

[00:00] Introduction to Longevity and Healthspan
[01:07] Meet Dr. Eric Verde: A Pioneer in Aging Research
[02:24] Exploring Therapeutic Plasma Exchange
[03:08] The Science Behind Heterochronic Parabiosis
[07:17] Clinical Trials and Methodologies
[12:58] The Role of Omics in Precision Medicine
[17:20] Epigenetic Clocks and Aging
[22:04] Therapeutic Plasma Exchange: Results and Implications
[26:22] Exploring Frequency and Efficacy of Treatments
[28:23] Biomarkers and Predictive Models
[31:33] Safety Profile and Side Effects
[33:28] Intrinsic Capacity and Aging Metrics
[36:58] Combining Treatments with Lifestyle Changes
[44:26] Future Directions and Recommendations
[49:08] Conclusion and Final Thoughts

We Appreciate You!
As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast
For science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

  continue reading

94 episodes

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