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In Memoriam: Prof Frank Beier - new insights into osteoarthritis onset (2021)

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Manage episode 506297230 series 3244565
Content provided by David Hunter and FRACP (Rheum). All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by David Hunter and FRACP (Rheum) or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

This week's episode is in honour of Frank Beier, who recently passed away on July 18, 2025. Frank leaves behind a remarkable legacy through the impact he made in the field of osteoarthritis. In this previous episode (2021), he discussed the recent advances in osteoarthritis understanding with a particular emphasis on novel targets and epigenetics.


Despite the large prevalence of osteoarthritis, there is no clinically approved drug which provides a cure. Currently, drugs focus on relieving symptoms such as pain. Experiments done in the laboratory have provided insight on osteoarthritis onset and progression and will likely guide therapeutic development.

We know that osteoarthritis is a disease of the whole organ meaning that any of the tissues involved in the synovial joint can be affected. The interplay between the various cell types involved is complex and understanding the interactions between cartilage, bone and synovium may be critical to therapeutic development.

Skeletal development likely plays a very important role in predisposition to disease. Through the identification of serious pathologies such as various forms of dwarfism (what in medical terms are called chondrodysplasias) the role of transcription factors and epigenetics is increasing our understanding of disease genesis.The study of the epigenetics of OA - the mechanism by which the human genome alters it’s gene expression (without changing the primary DNA sequence) has provided valuable information on novel risk factors for the disease and are potential therapeutic targets for OA.


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If you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!


Hosted on Acast. See acast.com/privacy for more information.

  continue reading

153 episodes

Artwork
iconShare
 
Manage episode 506297230 series 3244565
Content provided by David Hunter and FRACP (Rheum). All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by David Hunter and FRACP (Rheum) or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

This week's episode is in honour of Frank Beier, who recently passed away on July 18, 2025. Frank leaves behind a remarkable legacy through the impact he made in the field of osteoarthritis. In this previous episode (2021), he discussed the recent advances in osteoarthritis understanding with a particular emphasis on novel targets and epigenetics.


Despite the large prevalence of osteoarthritis, there is no clinically approved drug which provides a cure. Currently, drugs focus on relieving symptoms such as pain. Experiments done in the laboratory have provided insight on osteoarthritis onset and progression and will likely guide therapeutic development.

We know that osteoarthritis is a disease of the whole organ meaning that any of the tissues involved in the synovial joint can be affected. The interplay between the various cell types involved is complex and understanding the interactions between cartilage, bone and synovium may be critical to therapeutic development.

Skeletal development likely plays a very important role in predisposition to disease. Through the identification of serious pathologies such as various forms of dwarfism (what in medical terms are called chondrodysplasias) the role of transcription factors and epigenetics is increasing our understanding of disease genesis.The study of the epigenetics of OA - the mechanism by which the human genome alters it’s gene expression (without changing the primary DNA sequence) has provided valuable information on novel risk factors for the disease and are potential therapeutic targets for OA.


RESOURCES

Journal articles

CONNECT WITH US

If you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!


Hosted on Acast. See acast.com/privacy for more information.

  continue reading

153 episodes

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