Best Oncology Knowledge Into Practice Podcasts (2025)

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🧠💊⚖️ “Mood, Metabolism, and Meds: Decoding Antidepressant Side Effects” 4:52

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10h ago4:52

4:52

🔍 New in The Lancet! A massive network meta-analysis of 94 RCTs (105,435 patients) reveals that antidepressants impact far more than mood 🧠—they alter weight ⚖️, glucose 🩸, BP 💓, lipids 🧬, and liver enzymes 🧪. Agomelatine 🌙 may lower weight, while nortriptyline 📈 raises heart rate. Time to rethink side-effect profiles when prescribing! 📚 Pills, Pre…

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Genome, Gender, and Her Burden of Blue: The Genetics of Depression 7:40

21h ago7:40

7:40

🧬 Her Genes, His Risk, Our Mind 💡 New insights from Thomas et al., Nature Communications (2025) — summarized beautifully by Na Cai in Nature News & Views. Women carry a heavier polygenic burden for major depressive disorder (MDD), with ~6,000 female-specific variants and stronger genetic links to metabolic traits like BMI and metabolic syndrome. 🧠 …

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🦷 “Mouth to Myocardium to Mortality: How Oral Bacteria Hijack the Heart” 4:33

1d ago4:33

4:33

🦷🫀 New Findings Linking Oral Health to Heart Attacks! 🧬🧫 Groundbreaking research in JAHA reveals that viridans streptococci, common oral bacteria, form biofilms in atherosclerotic plaques that evade immune detection. These stealthy invaders trigger innate and adaptive immune responses, correlating with plaque rupture, myocardial infarction, and sud…

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Why Alzheimer Hits Women Harder: 🧬 From APOE4 to Estradiol 4:23

1d ago4:23

4:23

🧠 Why Does Alzheimer’s Affect More Women Than Men? New insights from JAMA Medical News reveal that the answer goes far beyond longevity. 🌸 Biology, hormones, and even social factors intertwine — from estrogen decline and X chromosome genetics to APOE4 risks and underdiagnosis due to stronger verbal memory. Women make up two-thirds of all Alzheimer’…

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🌀 From Dizzy to Steady: Time Restricted Eating Tames Tachycardia, Tunes Mitochondria, and Lifts Mood 4:58

2d ago4:58

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🚨 New Study Alert 🕒 Can when you eat improve how you feel? This open-label pilot study shows that Time-Restricted Eating (TRE) — limiting food intake to an 8–10 hour window — significantly improved: ✅ Quality of Life (↑ SF-36 & ↓ MAPS scores) ✅ Orthostatic Heart Rate (↓ by 11 bpm, p < 0.0001) ✅ Mitochondrial ATP production (↑, p < 0.05) TRE may off…

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A Podcast About Podcasts: Podcasts as Educational Tools for Providers (and Patients) 23:14

2d ago23:14

23:14

Dr. Chino welcomes Dr. Vivek Patel and Dr. Eleonora Teplinsky to discuss a recent article in JCO OP that reported a podcast-based curriculum could improve knowledge and comfort with common education topics for oncology fellows. TRANSCRIPT Dr. Fumiko Chino: Hello, and welcome to Put Into Practice, the podcast for JCO Oncology Practice. I am Dr. Fumi…

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Your Chronic Pain Has an Emotional Address: This App Finds the Root Cause with Creators Amy and Andrey Derevyanko | EP 113 34:39

3d ago34:39

34:39

What if your body isn't broken, but speaking a language you haven't learned to understand yet? Dr. Katie Deming sits down with Amy and Andrey Derevyanko, creators of an app helping everyday people explore the emotional roots of physical illness. Using principles from German New Medicine, their tool connects what’s happening in your body to what’s h…

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Dr RR Baliga's Philosophical Discourses: Guru Nanak (India, 1469–1539 CE) – Founder of Sikhism 3:32

3d ago3:32

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🌟 Guru Nanak (1469–1539 CE): The Voice of Oneness & Compassion 🌟 From Ik Onkar (One God) to Seva (selfless service), Guru Nanak’s message transcends faith — reminding us that true spirituality lies in equality, honesty, and compassion. 🕊️ His principles — Naam Japo (meditate), Kirat Karo (work honestly), Vand Shhako (share with others) — continue t…

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📉 Low Risk ≠ No Risk: CAC 🧠 Adds Predictive Power 5:24

3d ago5:24

5:24

🚨 New Study Alert 🩺 Think you’re low-risk? Think again. This MESA study shows that even “low-risk” individuals may harbor hidden coronary artery calcium (CAC) — and it matters. 📈 Adding CAC scoring significantly improved ASCVD risk prediction, reclassifying up to 18% into statin-eligible groups. 🧠 Implication? Precision prevention may start with a …

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Advance Care Planning: How Can We Improve Access and Uptake? 21:30

3d ago21:30

21:30

Dr. Chino welcomes Dr. Yael Schenker to discuss a new clinical trial testing the best way of engaging patients with Advance Care Planning (ACP), the process of understanding personal values, life goals, and medical care preferences so that patient wishes are honored at end-of-life. TRANSCRIPT Dr. Fumiko Chino: Hello, and welcome to Put Into Practic…

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🧬 Aging Hearts, Arrested Cells: The Cellular Villain in CardioVascular Aging 🫀 7:15

4d ago7:15

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🧬 Cellular senescence is more than just a marker of aging — it’s a key driver of ❤️ cardiovascular disease. From the p53/p21 and p16/Rb axes to mTOR, SIRT1/6, NF-κB, and ROS/DDR, these molecular pathways halt cell division, fuel inflammation 🔥, and impair cardiac repair. Emerging data spotlight the roles of 💣 SASP, 🧓 senescent MSCs, and 🎯 microRNAs…

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Leveraging Opportunistic CAC Detection from Routine Chest CT: ⚙️ From Pixels to Prevention 📊❤️ 5:14

4d ago5:14

5:14

🚨 Hidden heart risks in plain sight? 🫀🩻 The latest AHA Scientific Statement unveils the power of opportunistic coronary artery calcium (CAC) detection on routine noncardiac chest CTs. With AI-driven automation, we can now detect subclinical atherosclerosis, improve preventive therapy, and bridge disparities—all without additional imaging or cost. 💡…

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🛑 Retinas, Wrists & Risks: The Injury Epidemic in Pickleball 6:16

5d ago6:16

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🚨 Pickleball’s Popularity Comes at a Price 🎾👁️ As the fastest-growing sport in the U.S. hits 20M players, injuries—especially eye and orthopedic—are rising sharply 📈. New data from JAMA Ophthalmology and JAMA News & Analysis reveal alarming trends: retinal detachments, fractures, falls, and more—mostly in players over 50 👵🧓. Time to talk prevention…

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⚖️🧠🔻 “Heavy Yet Heart Healthy?” 4:03

5d ago4:03

4:03

🧬 New insights from Nature Medicine! Researchers reveal that obesity caused by MC4R deficiency — the most common monogenic form — is paradoxically linked to lower LDL-cholesterol, triglycerides, and blood pressure 💡. Despite severe obesity, these individuals show a “metabolically healthier” profile, likely due to altered central melanocortin signal…

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⚡ From Sample to Sequence to Solution Revolutionizing NICU Care with Same-Day Whole Genome Sequencing 4:20

6d ago4:20

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🚼 Game-changer in the NICU! Same-day genome sequencing using Sequencing by Expansion (SBX) delivered actionable results in under 7 hours for critically ill infants 🧬⏱️. Two life-altering diagnoses—including KCNQ2-related epilepsy—were identified faster than any existing rapid test. Published in The New England Journal of Medicine 📰. Precision care,…

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Desi Vessels, Dense Plaques, Diagnostic Gaps 🩻🧱📉 Redefining Subclinical Atherosclerosis in South Asians 8:23

7d ago8:23

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🩺 Desi Hearts, Hidden Plaques, Bold Truths 💓🫀📊 In the Atherosclerosis journal, Manubolu et al. use AI-powered CCTA to expose an alarming reality: 🧬 Young South Asians have high-risk plaque—even when CAC = 0. 📉 Risk scores fail to capture this. 📸 CCTA sees what traditional tools miss. It’s time to personalize prevention for Desi hearts. #CCTA #DesiH…

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Micro Detritus, Macro Damage, Global Dilemma 🌍🧬💔 6:21

7d ago6:21

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Microplastics — once dismissed as environmental debris — are now being found in the brain, placenta, heart, and bloodstream. 🧠🫀👶 Recent JAMA (2025) and NEJM (2024) studies link them to inflammation, oxidative stress, and higher cardiovascular risk. ⚠️ From beer to baby bottles, no corner of modern life is untouched. 🍺🍼 It’s time for urgent global a…

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⚠️ Belly Fat & Broken Hearts: The Adipokine Hypothesis of HFpEF 4:24

8d ago4:24

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🔬 New paradigm for HFpEF! 🧠 The Adipokine Hypothesis reframes preserved EF heart failure as an endocrine disorder driven by dysfunctional visceral fat. 🫀 Adipokines like leptin, aldosterone & neprilysin disrupt volume, inflammation & fibrosis. Target the fat ➡️ fix the heart! 💡 📄 JACC 2025 | Milton Packer MD #HFpEF #Cardiology #Adipokines #Visceral…

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Shingles, Shots, and Senility 🦠💉🧠 3:37

7d ago3:37

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🧠 New study in Nature Medicine links shingles (herpes zoster) to increased dementia risk — but there’s hope! 💉 Adults ≥50 who received zoster vaccines (ZVL or RZV) had significantly lower dementia rates 📉. Especially protective in older women 👵. Evidence mounts for VZV reactivation as a modifiable risk factor for neurodegeneration 🧬🛡️. 📚 Read more:…

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🧩 Matching RCTs to Reality: The Impella Data from Japan 6:14

9d ago6:14

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🚨 Real-World vs RCT? Only 1 in 3 patients with AMI-related cardiogenic shock in Japan met the 🔬 DanGer trial criteria for Impella use. The J-PVAD registry (🇯🇵, n=3975) reveals a stark ⚖️ reality: eligibility matters, and survival varies! 🫀 Time to align practice with precision. 📖 Read the full European Heart Journal study for clinical pearls and ca…

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📚 Learn. Use. Lead. A Clinician’s Guide to the GenAI Frontier 5:11

9d ago5:11

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🚨 New Era in Medicine! 🩺🤖 JAMA Internal Medicine highlights how Generative AI (GenAI) is reshaping clinical workflows—from AI scribes 📝 to diagnostic copilots 🧠. Physicians must prompt wisely, partner smartly, and practice responsibly. A must-read to stay ahead! 💡📈 #GenerativeAI #DigitalHealth #MedicalEducation #JAMA 🔗 https://jamanetwork.com/journ…

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🥑⚔️🧫 Immunity Meets Metabolism: The Fat-Absorption Trifecta 5:11

10d ago5:11

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🧠✨ New Science Perspective unpacks a “tripartite alliance” between TH17 cells, IL-22 cytokine signaling, and enterocytes in regulating fat absorption! 🥑🧫 Loss of Aster-A in T cells boosts IL-22, suppressing intestinal lipid uptake—a striking example of immune-metabolic crosstalk with implications for obesity and malabsorption. 🔬🛡️ 📘 Science, Oct 20…

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Why Some People Get Cancer and Others Don’t with Traditional Chinese Medicine Expert Brandon LaGreca | EP 112 52:27

9d ago52:27

52:27

What if cancer is a teacher inviting you to uncover the imbalances in your life? Dr. Katie Deming sits down with Brandon LaGreca, an licensed acupuncturist, author, and traditional Chinese medicine practitioner who once faced stage IV lymphoma, to explore a completely different lens on cancer. Brandon shares how Chinese medicine views cancer not as…

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Dr RR Baliga's Philosophical Discourses: Tulsidas (India, 1532–1623 CE) – Author of Ramcharitmanas 5:25

10d ago5:25

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🌸 Tulsidas (1511–1623 CE): India’s Poet of Devotion and Duty ✨ Bridging East and West, Tulsidas transformed spiritual thought much like Dante, Milton, and Luther did in Europe. His Ramcharitmanas made divine wisdom accessible to all, blending poetry, psychology, and ethics. 🌏 A timeless voice for compassion, virtue, and inner transformation — remin…

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Delay, Dose, Duration ⏳: The Triple Threat of LDL-C | Atherosclerosis doesn’t just depend on how high, but also how long and how late. 9:35

11d ago9:35

9:35

🧬💊 How long is too long to wait on statins? Two new studies reveal a powerful truth: ⏳ It’s not just how high your LDL is—but how long you’ve had it. 🔻 Delayed statin initiation (⏰ >6 months) after detecting high LDL-C is linked with increased risk of MI and stroke. 📆 Enter “Cholesterol-Years”—a concept akin to pack-years for smoking: the longer th…

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Biomarkers, Big Data & Biology: Mapping the Plasma Proteome Across 59 Diseases 2:57

11d ago2:57

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🧬 New Era in Blood-Based Biomarkers! 🩸 A pan-disease atlas of the circulating proteome across 59 diseases and 8,262 individuals reveals powerful insights into age, sex, BMI, and disease-specific protein signatures. 💡 Highlights: 🔹 Over 5,400 proteins profiled using Olink 🔹 Longitudinal stability of wellness proteome 🔹 Machine learning predicts biol…

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Ultraprocessed Foods (UPFs): 🥤Processed, Packaged, Perilous? 5:53

10d ago5:53

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📣 New in NEJM: Ultraprocessed Food on an Ultrafast Track 🥫⚡️ Are ultraprocessed foods (UPFs) really the villains of modern nutrition? 🤔 This thought-provoking piece critiques the Nova classification system 🧂📊 and urges caution before reshaping national dietary policy around it. From 🍟 glycemic spikes to 🧪 questionable additives, the debate is rich …

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🧬 The Double-Edged Blade of Antithrombotic Therapy in LVADs 5:22

12d ago5:22

5:22

🫀 New insights from EUROMACS registry! The latest JACC study explores the delicate ⚖️ trade-off between bleeding 🩸 and ischemic 🧠 events in LVAD patients. While HM3 reduces thrombotic risks, bleeding remains the dominant threat. Time to rethink the “one-size-fits-all” anticoagulation 🧪. Personalized strategies like LD-DOACs & lower INR targets may …

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MGUS Under the Microscope 🔬: From Screening to Significance 🚨 4:31

12d ago4:31

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🧬 New NEJM Review Alert! MGUS — once “undetermined,” now clinically significant. This comprehensive update by Rajkumar & Kumar reveals how asymptomatic plasma clones may drive renal (MGRS) and neurologic (MGNS) damage 🧠🩺 even without cancer. 🔬 Dive into new diagnostic pathways, risk models (iSTOPMM), and why “watch and wait” no longer fits for all.…

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💊Baxdrostat, Blood Pressure, Breakthrough! New Hope for Uncontrolled Hypertension 5:12

13d ago5:12

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🚨 New NEJM Study Alert! 🧬💊 Baxdrostat, a selective aldosterone synthase inhibitor, shows significant BP reduction in patients with resistant & uncontrolled hypertension despite RAAS blockade and diuretic therapy. ✅ SBP ↓ ~9–10 mmHg at 12 weeks 🧂 Targets salt-retaining physiology ⚖️ Well-tolerated: early mild hyperkalemia & hyponatremia 🔁 Durable ef…

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2025 ASCO Quality: Creating a Statewide Cancer Drug Repository Network to Improve Access and Affordability 21:17

12d ago21:17

21:17

Dr. Chino welcomes Dr. Emily Mackler, PharmD, BCOP, the Co-founder and Chief Medical Officer of the YesRx program and an Adjunct Clinical Associate Professor at the University of Michigan. The YesRx program has saved patients in Michigan more than 17 million dollars in the past 2 years. Dr. Mackler's article, "Transforming Cancer Drug Access: Insig…

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💔 Vulnerable Hearts. ⚠️ Hidden Risks. ⛑️ Wearable Cardioverter-Defibrillators 5:39

14d ago5:39

5:39

🚨 New insights from the SCD-PROTECT Study! 🫀 In a nationwide German cohort of 19,598 patients with newly diagnosed NICM or MI/CAD, early use of the Wearable Cardioverter-Defibrillator (WCD) offered critical protection during the high-risk window of guideline-directed therapy initiation. 📉 Most shocks occurred in the first 200 days 📈 >50% improved L…

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Hypothyroidism: Slowed Metabolism 🐢, Silent Symptoms 🤫, Serious Risks ⚠️ 9:03

14d ago9:03

9:03

📢 New JAMA Review Alert! 🦋 Hypothyroidism remains a silent disruptor of health — often underrecognized, yet linked with fatigue 😴, weight gain ⚖️, cardiovascular disease ❤️, and reproductive health challenges 🤰. This latest JAMA clinical review underscores: ✅ Autoimmunity (Hashimoto thyroiditis) as the leading cause ✅ Lifelong levothyroxine 💊 as fi…

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📲 Wearables Speak: A Minute of Vigrous Activity Is Worth an Hour of Light Physical Activity 6:48

15d ago6:48

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🚶‍♀️🏃‍♂️⏱️ Not all movement minutes are created equal! A major Nature Communications study using data from 73,000+ UK Biobank participants wearing accelerometers found: 1 minute of vigorous activity (VPA) = up to 9 mins moderate (MPA) or 94+ mins light (LPA) for reducing mortality, CVD, diabetes, and cancer risk. This rewrites the old 1:2 rule and …

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Hippocampus: Ripples 🌊, Riddles 🤔, Revelations ✨ 5:56

14d ago5:56

5:56

Hidden Horns 🐏, Silent Signals ⚡, New Memories 🧠 A new Science review reframes the hippocampus beyond the classic trisynaptic loop. Once-overlooked regions like CA2, fasciola cinereum, and indusium griseum — along with enigmatic signals such as small irregular activity (SIA) and dentate spikes (DS) — emerge as crucial for social memory, novelty det…

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🧭 Mapping the Large Vessel Vasculitis Landscape: Imaging, Immunity & Inflammation 📸🦠🗺️ 4:34

16d ago4:34

4:34

🚨 Just read the latest Lancet 2025 Seminar on Large-Vessel Vasculitis – a must-read for anyone tracking 🔍 Giant Cell Arteritis, 💥 Takayasu Arteritis, and 🧬 Isolated Aortitis. From 🚑 clinical phenotypes to 🧠 imaging advances and 🎯 targeted biologics like tocilizumab and JAK inhibitors, this article bridges inflammation with innovation. 📸 Vascular im…

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🧪 Gut Check: Sweeteners, Bugs & Body Weight 6:44

15d ago6:44

6:44

🍬 Can sweeteners help you stay slim? A new 1-year multicenter RCT in Nature Metabolism shows that replacing sugar with sweeteners & sweetness enhancers supports modest weight loss maintenance ⚖️ and beneficial gut microbiota shifts 🦠—with no adverse cardiometabolic effects 💓. 🚫 Less sugar, ✔️ better weight control, 🧬 smarter microbiota. The future …

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🧬 Blocking TGF-β, Boosting Function, Sotatercept’s Early Advantage inPAH 5:08

16d ago5:08

5:08

By MasterMedFacts LLC

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How Pets Reflect Our Healing Journey with Dr. Maureen McMichael, Veterinary and Pet Health Specialist | EP 111 38:05

16d ago38:05

38:05

By Dr. Katie Deming, M.D. | Conscious Oncologist

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Dr RR Baliga's Philosophical Discourses: Wang Yangming (China, 1472–1529 CE) – Neo-Confucian Philosopher 3:44

16d ago3:44

3:44

By MasterMedFacts LLC

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Steps, Scores, and SDGs 🚶‍♀️🧮🎯: Charting Africa’s Cardiovascular Future 5:36

17d ago5:36

5:36

By MasterMedFacts LLC

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🌕🩸🧠 Menstrual Rhythms: Meddlesome Moon & Meandering Minds 8:02

17d ago8:02

8:02

🩸🌕🧠 Menstrual Rhythms: Meddlesome Moon & Meandering Minds Two compelling studies—one from Science Advances and another from BMJ Mental Health—reveal how lunar phases may influence menstrual cycles, and how hormonal rhythms shape psychiatric symptoms. It’s time we treat the menstrual cycle as a vital sign in mental health, not an afterthought. 🔁 Fro…

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From Gene to Lipid to Clinic: The Rise of RNA Therapies 6:32

19d ago6:32

6:32

🚨 New NEJM study highlights a breakthrough in triglyceride management! 🧬 In the ESSENCE–TIMI 73b trial, monthly subcutaneous olezarsen targeting APOC3 cut triglycerides by ~60% at 6 months 📉—with strong safety and nearly 90% reaching normal TG levels. A promising step in precision lipid therapy! 💉🫀 #Lipidology #RNAtherapeutics #Cardiology #NEJM #Ol…

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💃🫀 “Dance of Neurons, Song of the Heart: Art as a Fountain of Youth 8:51

19d ago8:51

8:51

🎶 Can creativity and song keep us young? 🧠💓 New research reveals that creative pursuits — from 🎨 painting and 🎻 music to 💃 tango and 🕹️ gaming — can delay brain aging by enhancing neural efficiency and connectivity. Similarly, singing synchronizes heart rate and respiration, promoting cardiovascular balance and emotional well-being. Both studies hi…

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Early Breakfast & the Heart: Global Lessons 🌍🥣🫀 11:21

19d ago11:21

11:21

🌍🥣 Early Breakfast & the Heart 🫀 (Early to Breakfast and Early to Bed Makes You Heart Healthy & Wise!) From the UK to Spain to the US, evidence keeps piling up: skipping or delaying breakfast is more than a lifestyle choice — it’s linked to multimorbidity, subclinical atherosclerosis, and higher cardiovascular & stroke mortality. 🧬 Genes shape when…

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Fitness 🏋️, Formate ⚗️, Fireup T Cells 🔥, Fight Cancer 🕊️ 3:18

19d ago3:18

3:18

💪 Exercise does more than build strength — it reshapes the gut microbiome to fight cancer. A new Cell study shows that running increases microbiota-derived formate ⚗️, which supercharges CD8 T cell immunity 🛡️ and boosts the effectiveness of immune checkpoint inhibitors 🎯. 🔬 From treadmill mice to human microbiota analyses, the evidence points to f…

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🔥 Inflammation, 🫀 Heart, 🧪 Healing: 2025 ACC Scientific Statement 7:22

21d ago7:22

7:22

2025 ACC Scientific Statement on Inflammation & Cardiovascular Disease 🫀🔥. Key insights: ✅ hsCRP is as powerful as LDL in predicting risk. ✅ Low-dose colchicine 💊 now FDA-approved for secondary prevention. ✅ Lifestyle matters—Mediterranean diet 🥗, exercise 🏃, no smoking 🚭. ✅ Future therapies: IL-1 & IL-6 inhibitors, cardioimmunology 🧬. The science …

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Mitochondria, Mistakes, 🧬 InflammAgeing 5:19

20d ago5:19

5:19

🔬 Exciting new insights from Nature (2025)! When mitochondria run low on the right building blocks (deoxyribonucleotides), they mistakenly weave ribonucleotides into their DNA 🧬. The result? Fragile mitochondrial DNA gets expelled, setting off the cGAS–STING pathway and fueling inflammation 🔥—a key feature of ageing and senescence. 🧪 In MGME1-defic…

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🎙️🫀 The Asymptomatic Aortic Stenosis Dilemma: Act Early or Wait Carefully, 🧠 Experts Differ 3:04

22d ago3:04

3:04

🔍 Two influential viewpoints just dropped in JAMA Cardiology on aortic valve replacement (AVR) in asymptomatic severe aortic stenosis (AS). 🫀 Lindman, Braunwald & Pellikka argue that the time has come to move from “watchful waiting” to early intervention (SAVR/TAVR), citing RCTs showing reduced stroke, heart failure hospitalization, and unplanned C…

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🧬 Cancer, 🕰️ Ageing, 🔄 Evolution 5:26

21d ago5:26

5:26

“The Evolution of Cancer and Ageing: A History of Constraint” (Nature Reviews Cancer). Fascinating perspective on how tumour suppression mechanisms that protect us early in life may ironically fuel age-related decline later on. ⚖️ From telomeres 🧬 to stem cells 🌱, and from mole rats 🐀 to tortoises 🐢, evolution has shaped a delicate trade-off betwee…