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🧬 Blocking TGF-β, Boosting Function, Sotatercept's Early Advantage inPAH
Manage episode 511985030 series 2740117
Content provided by MasterMedFacts LLC, Dr RR Baliga, MD, and MBA. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC, Dr RR Baliga, MD, and MBA or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
🚨 Just out in NEJM! In the Phase 3 HYPERION trial, adding sotatercept early in pulmonary arterial hypertension (PAH) slashed clinical worsening risk by 76% vs placebo (HR 0.24, P<0.001) 💉🫁
💡 Benefits appeared after just 3 doses, with improved 6-min walk, NT-proBNP, and risk scores. Most AEs were mild (epistaxis, telangiectasia).
📊 A game-changer in early PAH therapy. NNT = 5 over 12 months.
🔗 #Cardiology #PulmonaryHypertension #Sotatercept #NEJM #PrecisionMedicine #ClinicalTrials #RightHeart #TGFb #REVEAL #COMPERA
753 episodes
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Manage episode 511985030 series 2740117
Content provided by MasterMedFacts LLC, Dr RR Baliga, MD, and MBA. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC, Dr RR Baliga, MD, and MBA or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
🚨 Just out in NEJM! In the Phase 3 HYPERION trial, adding sotatercept early in pulmonary arterial hypertension (PAH) slashed clinical worsening risk by 76% vs placebo (HR 0.24, P<0.001) 💉🫁
💡 Benefits appeared after just 3 doses, with improved 6-min walk, NT-proBNP, and risk scores. Most AEs were mild (epistaxis, telangiectasia).
📊 A game-changer in early PAH therapy. NNT = 5 over 12 months.
🔗 #Cardiology #PulmonaryHypertension #Sotatercept #NEJM #PrecisionMedicine #ClinicalTrials #RightHeart #TGFb #REVEAL #COMPERA
753 episodes
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Similar to Dr RR Baliga's "Got Knowledge Doc" Podkast
How many organs could you donate and remain alive? How many planet Earths could fit inside the Sun? How high is a giraffe's blood pressure? Why is the sea blue? To find out, Ask The Naked Scientists!
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…
continue reading
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