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Content provided by Mark Pettus MD and John Bagnulo PhD, MPH, Mark Pettus MD, John Bagnulo PhD, and MPH. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Mark Pettus MD and John Bagnulo PhD, MPH, Mark Pettus MD, John Bagnulo PhD, and MPH or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
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Four Days to Metabolic Flexibility: What a Danish Crossover Trial Reveals About Carbs, Fat, and Fatty Liver

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Manage episode 512372637 series 3493259
Content provided by Mark Pettus MD and John Bagnulo PhD, MPH, Mark Pettus MD, John Bagnulo PhD, and MPH. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Mark Pettus MD and John Bagnulo PhD, MPH, Mark Pettus MD, John Bagnulo PhD, and MPH or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

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A 35% drop in liver fat in under a week sounds impossible—until you see how a simple macro shift can redirect your metabolism. We dive into a Danish crossover study where calories stayed equal, protein held steady, and the only real change was carbohydrates versus fat. The result: rapid reductions in hepatic fat, lower triglycerides, improved insulin sensitivity, and clear signs of metabolic flexibility, all in four to five days. We unpack what that means for everyday eating, how to use CGM feedback to reduce glucose spikes, and why outcomes like organ fat and fat oxidation should trump a single lipid reading taken out of context.
From there, we widen the lens. Fatty liver—now recognized as a hallmark of metabolic dysfunction—is staggeringly common, yet highly responsive to nutrition quality and distribution. We break down why modest carb moderation paired with quality fats and robust protein can stabilize energy, support endogenous GLP-1 signaling, and protect lean mass. We also confront a common confusion: “high fat” isn’t a license for ultra-processed oils or low-fiber meals. When fats come from olive oil, avocado, nuts, eggs, and fish—and plants supply fiber and polyphenols—the microbiome, mitochondria, and glycemic control can all improve together.
We close with practical implications for anyone using GLP-1 medications. Pharmacology can provide short-term traction, but it doesn’t guarantee nourishment. A protein-forward, lower-glycemic template plus resistance training helps preserve muscle, sustain satiety, and potentially reduce medication reliance over time. If you’re ready to swap shaky biomarkers for meaningful outcomes—and to see changes fast—this conversation offers a clear, evidence-backed roadmap. If it resonates, follow the show, share with a friend, and leave a quick review to help more listeners find The Health Edge.

www.thehealthedgepodcast.com

  continue reading

Chapters

1. Framing the Study and Why It Matters (00:00:00)

2. Design: Low-Carb vs High-Carb Crossover (00:02:20)

3. Rapid Results: Liver Fat Down 35% (00:04:40)

4. Metabolic Flexibility and Ketones (00:07:10)

5. Triglycerides, Insulin, and Better Markers (00:10:20)

6. Prevalence of Fatty Liver and Risk (00:12:40)

7. Rethinking Biomarkers vs Outcomes (00:15:20)

8. Continuous Glucose Monitoring Insights (00:18:10)

9. Long-Term Risk: Brain, Cancer, Lifespan (00:21:00)

10. Reconciling Guidelines with New Evidence (00:24:20)

11. Microbiome, GLP-1, and Satiety (00:27:00)

12. Meds as Triage, Nutrition as Strategy (00:30:00)

46 episodes

Artwork
iconShare
 
Manage episode 512372637 series 3493259
Content provided by Mark Pettus MD and John Bagnulo PhD, MPH, Mark Pettus MD, John Bagnulo PhD, and MPH. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Mark Pettus MD and John Bagnulo PhD, MPH, Mark Pettus MD, John Bagnulo PhD, and MPH or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

Send us a text

A 35% drop in liver fat in under a week sounds impossible—until you see how a simple macro shift can redirect your metabolism. We dive into a Danish crossover study where calories stayed equal, protein held steady, and the only real change was carbohydrates versus fat. The result: rapid reductions in hepatic fat, lower triglycerides, improved insulin sensitivity, and clear signs of metabolic flexibility, all in four to five days. We unpack what that means for everyday eating, how to use CGM feedback to reduce glucose spikes, and why outcomes like organ fat and fat oxidation should trump a single lipid reading taken out of context.
From there, we widen the lens. Fatty liver—now recognized as a hallmark of metabolic dysfunction—is staggeringly common, yet highly responsive to nutrition quality and distribution. We break down why modest carb moderation paired with quality fats and robust protein can stabilize energy, support endogenous GLP-1 signaling, and protect lean mass. We also confront a common confusion: “high fat” isn’t a license for ultra-processed oils or low-fiber meals. When fats come from olive oil, avocado, nuts, eggs, and fish—and plants supply fiber and polyphenols—the microbiome, mitochondria, and glycemic control can all improve together.
We close with practical implications for anyone using GLP-1 medications. Pharmacology can provide short-term traction, but it doesn’t guarantee nourishment. A protein-forward, lower-glycemic template plus resistance training helps preserve muscle, sustain satiety, and potentially reduce medication reliance over time. If you’re ready to swap shaky biomarkers for meaningful outcomes—and to see changes fast—this conversation offers a clear, evidence-backed roadmap. If it resonates, follow the show, share with a friend, and leave a quick review to help more listeners find The Health Edge.

www.thehealthedgepodcast.com

  continue reading

Chapters

1. Framing the Study and Why It Matters (00:00:00)

2. Design: Low-Carb vs High-Carb Crossover (00:02:20)

3. Rapid Results: Liver Fat Down 35% (00:04:40)

4. Metabolic Flexibility and Ketones (00:07:10)

5. Triglycerides, Insulin, and Better Markers (00:10:20)

6. Prevalence of Fatty Liver and Risk (00:12:40)

7. Rethinking Biomarkers vs Outcomes (00:15:20)

8. Continuous Glucose Monitoring Insights (00:18:10)

9. Long-Term Risk: Brain, Cancer, Lifespan (00:21:00)

10. Reconciling Guidelines with New Evidence (00:24:20)

11. Microbiome, GLP-1, and Satiety (00:27:00)

12. Meds as Triage, Nutrition as Strategy (00:30:00)

46 episodes

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