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The quest to understand persistent brain symptoms after concussion has puzzled doctors and researchers for decades. What happens when the brain doesn't heal as expected? Why do some patients develop long-term problems while others recover completely?
Dr. Mavrudis, consultant neurologist and pioneering researcher, pulls back the curtain on these mysteries by revealing surprising connections between post-concussion syndrome, functional neurological disorders, and even long COVID. At the heart of his research is a revolutionary perspective: these seemingly different conditions share fundamental mechanisms related to neuroplasticity – the brain's ability to adapt and form new connections. When this process breaks down at the synaptic level, where neurons communicate, symptoms persist despite normal-appearing brain scans.
The conversation takes us deep into the cutting-edge world of brain biomarkers – molecular messengers that could revolutionize how we diagnose and treat concussions. Dr. Mavrudis explains how his team is developing cloud applications and machine learning algorithms to interpret patterns in these biomarkers, potentially allowing doctors to predict which patients will develop serious problems and tailor treatments accordingly. Particularly promising is his work on CGRP biomarkers for post-traumatic headaches, offering hope to many patients dissatisfied with current treatments.
But perhaps most refreshing is Dr. Mavrudis' holistic approach to treatment. Rather than reaching first for medications, he emphasizes behavioral therapies, appropriate exercise, stress management, and addressing cervical injuries that invariably accompany concussions. "The brain doesn't exist in isolation," he reminds us, highlighting how liver function, kidney health, and even gut activity significantly impact brain recovery.
Whether you're struggling with persistent symptoms after a concussion, caring for someone who is, or simply fascinated by the frontiers of neuroscience, this episode offers a roadmap to understanding the complex interconnections of brain injury and recovery.

Dr. Mavroudis: Website

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