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What Is Next After the Apple Watch?
Manage episode 523392908 series 2981357
What if you could see your inflammation—and your pace of aging—from your kitchen table? We sit down with Bob Messerschmidt, an optical engineer turned Apple platform architect who helped seed Apple Health and the Apple Watch, then left to build a simple at-home device that measures ESR, a century‑old inflammation marker with fresh relevance for longevity.
We unpack why chronic inflammation drives heart disease, stroke, neurodegeneration, and metabolic dysfunction, and why a single, trackable number can change behavior more than any abstract advice. You’ll hear a clear breakdown of ESR vs CRP: how CRP reacts fast to single-protein changes while ESR integrates multiple inflammatory pathways over several days, often acting like a steadier signal for lifestyle experiments. We explore compelling evidence that ESR rises with age in Western populations—functioning as a biological clock—yet flattens in agrarian cohorts, underscoring how environment and habits accelerate “inflammaging.”
Beyond theory, we get practical. Our guest shares what actually lowers ESR: meaningful weight loss, GLP‑1 therapies, omega‑3 rich fish, better sleep, daily movement, strength training, stress control, and even tart cherry juice. We talk about the design constraints that make wrist sensors tricky, why Apple prioritizes validation over speed, and how bringing blood-based testing into the home removes friction that once sidelined ESR in centralized lab workflows. With more than ten thousand tests across a diverse user base, the team is preparing anonymized insights and research in underserved communities to show which interventions move the needle in the real world.
If you want a reliable, weekly feedback loop that ties your choices to measurable change, this conversation maps the path. Subscribe, share with a friend who cares about longevity, and leave a review to help more people discover smarter ways to measure and lower inflammation.
Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/
Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/
Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin
At home blood testing (20% off) https://siphoxhealth.com/lufkin
Web: https://robertlufkinmd.com/
X: https://x.com/robertlufkinmd
Youtube: https://www.youtube.com/robertLufkinmd
Instagram: https://www.instagram.com/robertlufkinmd/
LinkedIn: https://www.linkedin.com/in/robertlufkinmd/
TikTok: https://www.tiktok.com/@robertlufkin
Threads: https://www.threads.net/@robertlufkinmd
Facebook: https://www.facebook.com/robertlufkinmd
Bluesky: ...
Chapters
1. What Is Next After the Apple Watch? (00:00:00)
2. From Biochemistry To Apple (00:00:02)
3. Cold Emailing Steve Jobs (00:02:52)
4. Founding Apple Health And Watch Origins (00:04:14)
5. Why Watch Innovation Feels Slower (00:06:56)
6. The Wrist Problem In Health Sensing (00:10:36)
7. Introducing Core’s At‑Home ESR Device (00:11:46)
8. Inflammation 101 And Why It Matters (00:12:19)
9. ESR vs CRP: Signals And Kinetics (00:15:23)
10. ESR As An Aging Clock (00:19:54)
11. What Lowers ESR: Drugs And Lifestyle (00:23:31)
12. Data, Research, And Underserved Communities (00:27:20)
13. Fasting Experiments And Future Roadmap (00:31:19)
14. Where To Find Core Health (00:41:56)
236 episodes
Manage episode 523392908 series 2981357
What if you could see your inflammation—and your pace of aging—from your kitchen table? We sit down with Bob Messerschmidt, an optical engineer turned Apple platform architect who helped seed Apple Health and the Apple Watch, then left to build a simple at-home device that measures ESR, a century‑old inflammation marker with fresh relevance for longevity.
We unpack why chronic inflammation drives heart disease, stroke, neurodegeneration, and metabolic dysfunction, and why a single, trackable number can change behavior more than any abstract advice. You’ll hear a clear breakdown of ESR vs CRP: how CRP reacts fast to single-protein changes while ESR integrates multiple inflammatory pathways over several days, often acting like a steadier signal for lifestyle experiments. We explore compelling evidence that ESR rises with age in Western populations—functioning as a biological clock—yet flattens in agrarian cohorts, underscoring how environment and habits accelerate “inflammaging.”
Beyond theory, we get practical. Our guest shares what actually lowers ESR: meaningful weight loss, GLP‑1 therapies, omega‑3 rich fish, better sleep, daily movement, strength training, stress control, and even tart cherry juice. We talk about the design constraints that make wrist sensors tricky, why Apple prioritizes validation over speed, and how bringing blood-based testing into the home removes friction that once sidelined ESR in centralized lab workflows. With more than ten thousand tests across a diverse user base, the team is preparing anonymized insights and research in underserved communities to show which interventions move the needle in the real world.
If you want a reliable, weekly feedback loop that ties your choices to measurable change, this conversation maps the path. Subscribe, share with a friend who cares about longevity, and leave a review to help more people discover smarter ways to measure and lower inflammation.
Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/
Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/
Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin
At home blood testing (20% off) https://siphoxhealth.com/lufkin
Web: https://robertlufkinmd.com/
X: https://x.com/robertlufkinmd
Youtube: https://www.youtube.com/robertLufkinmd
Instagram: https://www.instagram.com/robertlufkinmd/
LinkedIn: https://www.linkedin.com/in/robertlufkinmd/
TikTok: https://www.tiktok.com/@robertlufkin
Threads: https://www.threads.net/@robertlufkinmd
Facebook: https://www.facebook.com/robertlufkinmd
Bluesky: ...
Chapters
1. What Is Next After the Apple Watch? (00:00:00)
2. From Biochemistry To Apple (00:00:02)
3. Cold Emailing Steve Jobs (00:02:52)
4. Founding Apple Health And Watch Origins (00:04:14)
5. Why Watch Innovation Feels Slower (00:06:56)
6. The Wrist Problem In Health Sensing (00:10:36)
7. Introducing Core’s At‑Home ESR Device (00:11:46)
8. Inflammation 101 And Why It Matters (00:12:19)
9. ESR vs CRP: Signals And Kinetics (00:15:23)
10. ESR As An Aging Clock (00:19:54)
11. What Lowers ESR: Drugs And Lifestyle (00:23:31)
12. Data, Research, And Underserved Communities (00:27:20)
13. Fasting Experiments And Future Roadmap (00:31:19)
14. Where To Find Core Health (00:41:56)
236 episodes
All episodes
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