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🫀 Foxglove, Frailty, and HFrEF — Digitoxin in Advanced Heart Failure

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Manage episode 503362835 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

🚨 New RCT Alert from the NEJM!

Can an old 💊 make a comeback in modern 💓 failure care?

📌 The DIGIT-HF trial showed that digitoxin, a cardiac glycoside with hepatic clearance, reduced the combined endpoint of all-cause death or HF hospitalization in HFrEF patients on contemporary guideline-directed therapy — including ARNI, beta-blockers, MRAs & SGLT2i.

🩺 HR = 0.82; p = 0.03 📉

👩‍⚕️ Safe in CKD, consistent benefit in women.

⚠️ Serious AEs slightly higher (4.7% vs 2.8%)

📥 NNT = 22.

💡Is it time to reconsider digitoxin in advanced HFrEF?

#CardioTwitter #HFrEF #HeartFailure #Digitoxin #NEJM #Cardiology #SGLT2i #GuidelineTherapy

  continue reading

673 episodes

Artwork
iconShare
 
Manage episode 503362835 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.

🚨 New RCT Alert from the NEJM!

Can an old 💊 make a comeback in modern 💓 failure care?

📌 The DIGIT-HF trial showed that digitoxin, a cardiac glycoside with hepatic clearance, reduced the combined endpoint of all-cause death or HF hospitalization in HFrEF patients on contemporary guideline-directed therapy — including ARNI, beta-blockers, MRAs & SGLT2i.

🩺 HR = 0.82; p = 0.03 📉

👩‍⚕️ Safe in CKD, consistent benefit in women.

⚠️ Serious AEs slightly higher (4.7% vs 2.8%)

📥 NNT = 22.

💡Is it time to reconsider digitoxin in advanced HFrEF?

#CardioTwitter #HFrEF #HeartFailure #Digitoxin #NEJM #Cardiology #SGLT2i #GuidelineTherapy

  continue reading

673 episodes

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