Sep 05 2025 This Week in Cardiology

This Week in Cardiology

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The big beta-blocker story from ESC, dual pathway therapy with aspirin and OAC, stopping OAC after successful AF ablation, and DANCAVAS II trial are the topics John Mandrola, MD, discusses on this week's podcast.

This podcast is intended for healthcare professionals only.

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I Listener Feedback

This Week in Cardiology Podcast – August 29 https://www.medscape.com/viewarticle/1002877

II The Big Beta-blocker Story from ESC

Beta-Blockers Post-MI: A Clear Clinical Message https://www.medscape.com/viewarticle/beta-blockers-post-mi-clear-clinical-message-2025a1000mz0

REBOOT https://www.nejm.org/doi/full/10.1056/NEJMoa2504735
BETAMI-DANBLOCK https://www.nejm.org/doi/abs/10.1056/NEJMoa2505985

REDUCE AMI https://www.nejm.org/doi/10.1056/NEJMoa2401479
CAPITAL RCT https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199347
Post Hoc Analysis From REBOOT Trial https://eurointervention.pcronline.com/article/effect-of-beta-blocker-withholding-or-withdrawal-after-myocardial-infarction-without-reduced-ejection-fraction-on-ischaemic-events-a-post-hoc-analysis-from-the-reboot-trial
Beta-Blockers After MI With Mildly Reduced Ejection Fraction https://doi.org/10.1016/S0140-6736(25)01592-2
CAPRICORN 10.1016/S0140-6736(00)04560-8 External Link
BHAT https://jamanetwork.com/journals/jama/fullarticle/370103
ISIS 1 https://pubmed.ncbi.nlm.nih.gov/2873379/

III Aspirin and OAC Combination Clearly Dangerous

Aspirin Plus Oral Anticoagulants Raises Mortality, Bleeding https://www.medscape.com/viewarticle/aspirin-plus-oral-anticoagulants-raises-mortality-bleeding-2025a1000nam

AQUATIC https://www.nejm.org/doi/full/10.1056/NEJMoa2507532
AFIRE https://www.nejm.org/doi/full/10.1056/NEJMoa1904143
EPIC CAD https://www.nejm.org/doi/10.1056/NEJMoa2407362
OAC-ALONE https://pubmed.ncbi.nlm.nih.gov/30586700/

IV Stop or Continue OAC after Successful AF Ablation

ALONE-AF https://jamanetwork.com/journals/jama/fullarticle/2838294
OCEAN trial protocol https://doi.org/10.1016/j.ahj.2017.12.007

V DANCAVAS II Trial

DANCAVAS II https://doi.org/10.1093/eurheartj/ehaf704
DANCAVAS I https://www.nejm.org/doi/full/10.1056/NEJMoa2208681

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