This podcast delivers Dr. John Mandrola's summary and perspective on top news of the week that cardiologists can't miss. This podcast is intended for US health professionals only.
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Expertcommentary Podcasts
Welcome to "The AI Guys" podcast! Join hosts Lee Dickson and Rich Swier as they take you on a journey through the world of AI. In this episode, they share their personal journeys and experiences in the tech world. From discussing the parallels between the rise of the internet and AI, to exploring practical and technical aspects, Lee and Rich aim to make AI accessible and easy to understand for entrepreneurs, business owners, and the everyday consumer. With candid conversations and expert ins ...
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The Bob Harrington Show is a podcast series of thoughtful interviews and discussions on topics at the core of cardiology and the practice of medicine.
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Join Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, as they interview experts on the hottest topics in healthcare ranging from COVID-19 to social determinants of health to bringing humanity back to medicine.
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Vibe Coding, Legacy Systems & The "Tesla" Moment for Devs
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In this episode, The AI Guys tackle the rapidly widening gap in the software world. On one side, you have "Vibe Coders"—entrepreneurs and new devs using AI to generate entire applications via prompts, bypassing traditional coding struggles. On the other, you have enterprise teams managing 30-year-old legacy systems. Rich Swire breaks down how to br…
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The MI paradox of risk scores, the CELEBRATE trial of a new subcutaneous glycoprotein IIb/IIIA inhibitor (with its funny endpoint), the SURPASS CVOT trial, and the bad story of andexanet alfa are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript o…
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Why AI Adoption Is Slower Than You Think and How to Fix It
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Why is AI adoption so slow when the opportunity feels so massive? In this episode of the AI Guys Podcast, Lee and Rich sit down with Jason Jackson, Group AI Enablement Lead at Vista Software Group, to unpack the real-world challenges holding AI back. They discuss governance friction, legacy systems, legal uncertainty, and why constantly shifting AI…
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An elegant study in post-TAVI atrioventricular block, a PSA for my structural colleagues, revascularization in women, and a CTO PCI trial are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I A…
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2026 AI Outlook: The Great Startup Churn & Enterprise Adoption
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In this episode of the AI Guys, hosts Lee Dixon and Rich Swire wrap up 2025 by outlining the three critical trends that will define the next year of artificial intelligence. They move beyond the "experimental" phase to discuss why 2026 marks the end of "analysis paralysis" and the beginning of mandated business adoption where AI is embedded into th…
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Less is more after PCI, the TARGET-FIRST trial, a negative blood pressure trial that is actually positive, aspirin vs OAC for bleeding, AEDs, and Factor XI is not dead yet are the topics discussed by John Mandrola, MD, on this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, vis…
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AI in Development: The Shift from "Doer" to "Manager"
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In this episode of the AI Guys, hosts Lee Dickson and Rich Swier dive into the technical and cultural shifts AI is bringing to software development. They move beyond the basic use cases of GitHub Copilot to discuss the concept of the "Agentic Layer"—training AI on your specific schema, blueprints, and user guides to create a true collaborator. Rich…
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Build, Buy, or Embed: The Truth About Enterprise AI Strategies
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In this episode of the AI Guys, hosts Lee Dickson and Rich Swier tackle the "Build vs. Buy vs. Embed" dilemma. They explore why so many companies are tempted to simply "upgrade" their existing SaaS tools (like CRMs or Support desks) to include AI, and why Rich believes this often results in the "worst version of AI you could imagine." They discuss …
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Listener feedback, huge news in the world of carotid disease with the CREST-2 publication, prasugrel beats ticagrelor again, and a big coffee trial are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.co…
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Listener feedback on the PISCES trial, AHA news (including a big PCSK9i trial), beta-blockers post MI, LAAC, and post-AF ablation OAC use are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I L…
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The End of "Per Seat": Tokens as the New Currency for Work
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The "per seat" SaaS model is dead. The AI Guys break down "tokenomics", the new utility-based pricing model for AI that is replacing software subscriptions. Follow along with us as they show how productivity will likely be measured in corporations. Saas companies everywhere will need to pivot, and likely sooner than they think. Interested in A.I.? …
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Listener feedback on non-culprit PCI in STEMI, a major cardiac result in patients on hemodialysis, news on GLP-1 agonists, a dubious stroke trial, and an AHA preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https…
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3 Urgent Moves to Protect Your Business from AI Giants Now
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Are you feeling the squeeze? The era of free APIs and comfortable user interfaces is over. Lee and Rich discuss why the "battle for the middle"—the space between foundation models and user interfaces—is the new focus for tech giants. Learn the three immediate actions SaaS providers, e-commerce, and service companies must take to protect their reven…
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Four pillars of cardiology today, stable coronary artery disease, severe aortic stenosis, the evaluation of chest pain, and best therapies for atrial fibrillation are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://…
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SMuRF-less: CV Prevention Beyond Traditional Risk Factors
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Drs Harrington, Rodriguez, and Ridker discuss the changing field of cardiac prevention, where imaging fits in, and the new concept of standard modifiable risk factor-less patients. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Life's Essential 8: …
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How Evolved Models and Agentic Workflows Cut Your AI Costs Now
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Are high AI usage costs crippling your budget? Many are overspending by defaulting to the newest, most expensive reasoning models for simple tasks. The problem: The temptation to use "the biggest brain" for every job, leading to ballooning token costs and slow performance. The solution: Discover the power of specialized, smaller models and asynchro…
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The PREVENT score in hypertension, GLP-1 mechanism of action in cardiovascular disease, CAD type and statin benefit, and the problem with hospitalization endpoints in HF trials are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, v…
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Convert Your GPTs to Autonomous AI Agents NOW
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Struggling with the limits of your custom GPT prompts? Lee and Rich discuss the essential shift from simple desktop prompts to full, autonomous, and scalable AI agents. You've hit the memory wall and document limits; it's time to untether your best workflows. Discover how graduating to an agentic platform with vector stores, persistent memory, and …
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Another knock against the antiplatelet/anticoagulant combo, polypills in HF, the physical exam of the future, and the problem of underpowered trials that even Bayesian analyses cannot rescue are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or…
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The Ultimate AI Co-worker: How One Finance Team Found its AI Spark
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A CFO shares how her finance team, initially hesitant about AI, found excitement and a path to business automation by participating in an AI-powered music video contest. The episode details how they went from creating a music video with tools like ChatGPT and Neural Frames to applying those same skills to their day-to-day financial tasks. They disc…
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GLP-1 use in HFrEF, left atrial posterior wall isolation during AF ablation, peri-device leaks for LAAO, new findings in post-cardiac surgery AF, and imaging before AF ablation are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, v…
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Why AI Will Dismantle the SaaS Business Model
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Software as a Service (SaaS) companies are overspending on 'SaaS fat'—bloated software with features nobody uses. The AI Guys reveal how the traditional per-seat licensing model is becoming outdated, inefficient, and expensive. They reveal how AI is set to disrupt the SaaS industry by automating tasks and providing a more efficient, cost-effective,…
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Two great stories of translation science leading to beneficial drugs in terrible diseases of the heart and the Sisyphean task of predicting the need for pacing after TAVI are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: …
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Offshoring was once a strategic move for cost savings and scalability, but the rules are changing. Join the AI Guys as they discuss how the rise of AI is making it possible for companies to bring jobs back onshore. They break down how AI agents are becoming the new offshore workforce, handling tasks like customer support and routine operations, hel…
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A bold trial in valvular heart disease, a CV prevention trial whose message is humility, VTE dogma challenged, more news on oral GLP-1 agonists, and a few public service announcements are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to com…
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Many businesses are still relying on traditional chatbot builders and live chat solutions that are tethered to a single channel and burdened by expensive seat licensing models. This episode explains why a platform-based approach is the future of business. Learn how to untether your AI agents, orchestrate them across multiple channels, and own your …
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More trials at ESC, including PARACHUTE HF, DAPA ACT HF-TIMI 68, AMALFI, and a super-interesting modeling study of when to start oral anticoagulants in AF, are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.med…
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Nobel Laureate on Touch and the Joy of Scientific Discovery
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The 2021 winner of the Nobel Prize in medicine, Ardem Patapoutian speaks of his love for science, why he wishes he had an MD, and the importance of getting out of the lab to inspire young people. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington Nobe…
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AI Platforms vs. Workflow Engines: The Difference You Need to Know Now
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Many businesses confuse a workflow engine with a comprehensive AI platform, leading to "spaghetti code" and unmanageable, brittle solutions. This episode clarifies the crucial difference, explaining why platforms are essential for centralized management, security, and control of your AI agents. Learn how to use a workflow engine as a component of a…
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More from ESC including: Valvular HD guidelines, a new drug class for HTN, myosin inhibition in HCM, vericiguat, and digoxin are the topic discussed by John Mandrola, MD. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I New European Valvular Heart Disease …
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The Education Elephant: A Blueprint for AI in a Slow-to-Change Industry
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Are you struggling to implement AI in a traditionally slow-to-change industry? Ed Buckley and Marlee Strawn, co-founders of Scholar Education, a platform using AI to transform learning, reveal their strategy for winning over skeptical teachers by co-designing a solution that reduces workload and personalizes student support. Learn how they're tackl…
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The big beta-blocker story from ESC, dual pathway therapy with aspirin and OAC, stopping OAC after successful AF ablation, and DANCAVAS II trial are the topics John Mandrola, MD, discusses on this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/t…
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