Best Expertcommentary Podcasts (2026)

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The 3 Assets That Will Save Your Business in 2026 16:09

Play Pause

3h ago16:09

16:09

AI knowledge transfer is becoming one of the most critical business priorities as companies face employee turnover, retirements, and rapidly evolving technology stacks. In this episode, Lee Dixon and Rich Swier break down why institutional knowledge loss is one of the biggest hidden risks businesses will face in 2026 and beyond. They explore how AI…

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Jan 09 2026 This Week in Cardiology 28:28

8h ago28:28

28:28

The limits of knowing coronary artery disease anatomy, fish oil and AF risk, a new drug for PSVT, and maybe I was wrong about a drug for AF conversion (the RAFF4 trial). These are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, vi…

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How to Build AI Agents That Actually Work 25:17

18h ago25:17

25:17

In this episode of the AI Guys Podcast, Lee Dickson and Rich Swier break down what it really takes to build and deploy AI agents that deliver value. They cover the full lifecycle from development blueprints and data preparation to training, integrations, testing, and post-launch monitoring. If you are experimenting with AI agents or planning your f…

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Cardiovascular Medicine 2025 Wrapped: The Big Picture 31:50

15d ago31:50

31:50

Drs Harrington and Gibson's annual review of cardiovascular medicine: ACS guidelines, antiplatelet management, GLP-1s, and ever lower LDL-C with drugs or even gene editing are among the highlights. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington New…

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The AI Operating Model: Redefining the Org Chart for 2026 22:47

8d ago22:47

22:47

In this episode, Lee and Rich dive into the operating model of the modern company as we approach 2026. The conversation moves beyond simple chatbots and into the realm of AI Agents—software that doesn't just answer questions but performs tasks. Rich argues that knowledge-based businesses (like consultancies) must start thinking like manufacturers, …

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Vibe Coding, Legacy Systems & The "Tesla" Moment for Devs 21:49

15d ago21:49

21:49

In this episode, The AI Guys tackle the rapidly widening gap in the software world. On one side, you have "Vibe Coders"—entrepreneurs and new devs using AI to generate entire applications via prompts, bypassing traditional coding struggles. On the other, you have enterprise teams managing 30-year-old legacy systems. Rich Swire breaks down how to br…

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Dec 19 2025 This Week in Cardiology 35:37

19d ago35:37

35:37

The MI paradox of risk scores, the CELEBRATE trial of a new subcutaneous glycoprotein IIb/IIIA inhibitor (with its funny endpoint), the SURPASS CVOT trial, and the bad story of andexanet alfa are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript o…

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Why AI Adoption Is Slower Than You Think and How to Fix It 33:35

25d ago33:35

33:35

Why is AI adoption so slow when the opportunity feels so massive? In this episode of the AI Guys Podcast, Lee and Rich sit down with Jason Jackson, Group AI Enablement Lead at Vista Software Group, to unpack the real-world challenges holding AI back. They discuss governance friction, legacy systems, legal uncertainty, and why constantly shifting AI…

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Dec 12 2025 This Week in Cardiology 27:51

25d ago27:51

27:51

An elegant study in post-TAVI atrioventricular block, a PSA for my structural colleagues, revascularization in women, and a CTO PCI trial are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I A…

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2026 AI Outlook: The Great Startup Churn & Enterprise Adoption 20:35

29d ago20:35

20:35

In this episode of the AI Guys, hosts Lee Dixon and Rich Swire wrap up 2025 by outlining the three critical trends that will define the next year of artificial intelligence. They move beyond the "experimental" phase to discuss why 2026 marks the end of "analysis paralysis" and the beginning of mandated business adoption where AI is embedded into th…

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Dec 05 2025 This Week in Cardiology 29:58

1M ago29:58

29:58

Less is more after PCI, the TARGET-FIRST trial, a negative blood pressure trial that is actually positive, aspirin vs OAC for bleeding, AEDs, and Factor XI is not dead yet are the topics discussed by John Mandrola, MD, on this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, vis…

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AI in Development: The Shift from "Doer" to "Manager" 20:29

1M ago20:29

20:29

In this episode of the AI Guys, hosts Lee Dickson and Rich Swier dive into the technical and cultural shifts AI is bringing to software development. They move beyond the basic use cases of GitHub Copilot to discuss the concept of the "Agentic Layer"—training AI on your specific schema, blueprints, and user guides to create a true collaborator. Rich…

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Build, Buy, or Embed: The Truth About Enterprise AI Strategies 18:01

1M ago18:01

18:01

In this episode of the AI Guys, hosts Lee Dickson and Rich Swier tackle the "Build vs. Buy vs. Embed" dilemma. They explore why so many companies are tempted to simply "upgrade" their existing SaaS tools (like CRMs or Support desks) to include AI, and why Rich believes this often results in the "worst version of AI you could imagine." They discuss …

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Nov 21 2025 This Week in Cardiology 29:00

2M ago29:00

29:00

Listener feedback, huge news in the world of carotid disease with the CREST-2 publication, prasugrel beats ticagrelor again, and a big coffee trial are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.co…

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Nov 14 2025 This Week in Cardiology 36:50

2M ago36:50

36:50

Listener feedback on the PISCES trial, AHA news (including a big PCSK9i trial), beta-blockers post MI, LAAC, and post-AF ablation OAC use are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I L…

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The End of "Per Seat": Tokens as the New Currency for Work 30:38

2M ago30:38

30:38

The "per seat" SaaS model is dead. The AI Guys break down "tokenomics", the new utility-based pricing model for AI that is replacing software subscriptions. Follow along with us as they show how productivity will likely be measured in corporations. Saas companies everywhere will need to pivot, and likely sooner than they think. Interested in A.I.? …

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Nov 07, 2025 This Week in Cardiology 32:17

2M ago32:17

32:17

Listener feedback on non-culprit PCI in STEMI, a major cardiac result in patients on hemodialysis, news on GLP-1 agonists, a dubious stroke trial, and an AHA preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https…

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3 Urgent Moves to Protect Your Business from AI Giants Now 24:58

2M ago24:58

24:58

Are you feeling the squeeze? The era of free APIs and comfortable user interfaces is over. Lee and Rich discuss why the "battle for the middle"—the space between foundation models and user interfaces—is the new focus for tech giants. Learn the three immediate actions SaaS providers, e-commerce, and service companies must take to protect their reven…

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Oct 31 2025 This Week in Cardiology 31:13

2M ago31:13

31:13

Four pillars of cardiology today, stable coronary artery disease, severe aortic stenosis, the evaluation of chest pain, and best therapies for atrial fibrillation are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://…

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SMuRF-less: CV Prevention Beyond Traditional Risk Factors 24:06

2M ago24:06

24:06

Drs Harrington, Rodriguez, and Ridker discuss the changing field of cardiac prevention, where imaging fits in, and the new concept of standard modifiable risk factor-less patients. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington Life's Essential 8: …

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How Evolved Models and Agentic Workflows Cut Your AI Costs Now 21:53

2M ago21:53

21:53

Are high AI usage costs crippling your budget? Many are overspending by defaulting to the newest, most expensive reasoning models for simple tasks. The problem: The temptation to use "the biggest brain" for every job, leading to ballooning token costs and slow performance. The solution: Discover the power of specialized, smaller models and asynchro…

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Oct 24 2025 This Week in Cardiology 30:24

2M ago30:24

30:24

The PREVENT score in hypertension, GLP-1 mechanism of action in cardiovascular disease, CAD type and statin benefit, and the problem with hospitalization endpoints in HF trials are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, v…

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Convert Your GPTs to Autonomous AI Agents NOW 25:35

3M ago25:35

25:35

Struggling with the limits of your custom GPT prompts? Lee and Rich discuss the essential shift from simple desktop prompts to full, autonomous, and scalable AI agents. You've hit the memory wall and document limits; it's time to untether your best workflows. Discover how graduating to an agentic platform with vector stores, persistent memory, and …

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Oct 17 2025 This Week in Cardiology 32:01

3M ago32:01

32:01

Another knock against the antiplatelet/anticoagulant combo, polypills in HF, the physical exam of the future, and the problem of underpowered trials that even Bayesian analyses cannot rescue are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or…

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The Ultimate AI Co-worker: How One Finance Team Found its AI Spark 31:50

3M ago31:50

31:50

A CFO shares how her finance team, initially hesitant about AI, found excitement and a path to business automation by participating in an AI-powered music video contest. The episode details how they went from creating a music video with tools like ChatGPT and Neural Frames to applying those same skills to their day-to-day financial tasks. They disc…

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Oct 10 2025 This Week in Cardiology 26:02

3M ago26:02

26:02

GLP-1 use in HFrEF, left atrial posterior wall isolation during AF ablation, peri-device leaks for LAAO, new findings in post-cardiac surgery AF, and imaging before AF ablation are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, v…

4M ago33:55

33:55

More trials at ESC, including PARACHUTE HF, DAPA ACT HF-TIMI 68, AMALFI, and a super-interesting modeling study of when to start oral anticoagulants in AF, are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.med…