This podcast delivers Dr. John Mandrola’s summary and perspective on top news of the week that cardiologists can’t miss. This podcast is intended for US health professionals only.
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The Bob Harrington Show is a podcast series of thoughtful interviews and discussions on topics at the core of cardiology and the practice of medicine.
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Welcome to "The AI Guys" podcast! Join hosts Lee Dickson and Rich Swier as they take you on a journey through the world of AI. In this episode, they share their personal journeys and experiences in the tech world. From discussing the parallels between the rise of the internet and AI, to exploring practical and technical aspects, Lee and Rich aim to make AI accessible and easy to understand for entrepreneurs, business owners, and the everyday consumer. With candid conversations and expert ins ...
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Join Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, as they interview experts on the hottest topics in healthcare ranging from COVID-19 to social determinants of health to bringing humanity back to medicine.
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Finding Your AI Soulmate: The Key to a Perfect Partnership
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23:05Feeling lost in the complex world of AI, unsure who to trust with your future? Finding the perfect AI partner is crucial for long-term success. In this episode, we unveil the crucial secret to AI success: finding the right partner. We go beyond the tech and explore the essential qualities of a strategic AI collaborator who can guide you towards an …
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The BedMed trial of nighttime BP meds, SURMOUNT-5, Troponin URL, gene tests in patients with no disease, and guideline-directed medical therapy for HF are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape…
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The Real Cost of AI: Understanding Your Investment and ROI
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28:10Thinking about investing in AI for your business but unsure of the real cost and potential returns? In this episode, we cut through the complexity to deliver a clear understanding of AI cost calculations and the path to significant ROI. Breaking down the investment required for both basic AI tools and scalable Agentic Workforces, revealing the key …
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The controversial KETO-CTA study, tough decisions in subclinical AF, and another potentially huge benefit for GLP-1 agonist drugs are discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I The KETO-CTA Stud…
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To Train Physicians of the Future We Can’t Be Stuck in the Past
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28:02The rejection by the ABMS of a certification board run by cardiologists prompted this discussion on how medical training should change and the best methods to assess clinical competency. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington New Cardiology…
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Manus vs. ChatGPT: A First Look at the New AI Contender
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25:34The way we interact with AI is changing. Forget basic commands; the future is collaborative. In this episode, we explore Manus, an exciting new AI model that's shifting the paradigm away from traditional prompt-response interactions, offering a glimpse into a more agent-like future. Join the AI Guys as they share their initial experiences with Manu…
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The FDA approval of TAVR for asymptomatic AS, digital health, subcutaneous vs transvenous ICD, and cryptogenic stroke in young adults are discussed by John Mandrola, MD. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I FDA announces approval for TAVR in pt…
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Vibe Coding: Building Apps with Words, Not Code
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32:55Forget complex code! In this episode we explore "vibe coding," a revolutionary approach to software development using natural language prompts. Discover how AI is empowering non-technical entrepreneurs and creators to rapidly prototype and build applications, potentially disrupting the traditional software development lifecycle. We take a look at t…
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AI and ECGs, novel ways to treat hypertension, combined lipid-lowering therapy after myocardial infarction, PFA and silent stroke, a move toward accountability in AF ablation, and pacing issues in TTVR are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial tr…
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AI for Freelancers: The Guide to Productivity and Profit
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41:49Are you ready to unlock your true potential as a freelancer? This episode dives into the revolutionary power of AI for independent professionals. We explore how AI is leveling the playing field, empowering individuals to achieve productivity and scale once reserved for large corporations. From automating tedious tasks to mastering client communicat…
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The FAME 3 trial 5-year results, TAVR at 5 years, pacers after TAVR, and mavacamten not a wonder drug are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I FAME 3 at Five Years Stents as Good a…
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AI vs. SaaS: The Future of Software Development
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41:34How is AI poised to revolutionize the software industry? In this episode, we explore AI’s potential to disrupt traditional SaaS models and reshape how applications are built and used. Diving into the concept of an "AI-first" mentality in software development, discussing how it could empower entrepreneurs, streamline workflows, and create more intui…
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April 11, 2025 This Week in Cardiology Podcast
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27:31The TAP-IT, STRIDE, FreshUP, and SINGLE SHOT CHAMPION trials are discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I TAP IT TAP IT trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.073521 …
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For America First, Invest in Science and the NIH
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29:33A panel discussion of a Presidential Advisory from the American Heart Association that outlines the importance of funding for scientific research and the need for a robust National Institutes of Health. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harringto…
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The Future of Medicine: AI-Powered Healthcare Solutions
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45:18Is AI the key to a healthier future? In this episode, we explore the transformative potential of AI in the healthcare industry. Ben Scharfe, joins us to discuss how AI is being leveraged to improve patient care, streamline clinician workflows, and revolutionize healthcare systems. We look into the challenges of AI adoption in healthcare, including …
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Trials from the 2025 American College of Cardiology scientific sessions, including the WARRIOR, PROTECT TAVI, DAPATAVI, and SOUL are reviewed by John Mandrola, MD This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Thank you Comments II WARRIOR Women’s Ischem…
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AI in Vegas: Hope or Hype? A Reality Check from HumanX
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20:41What were the real takeaways from the HumanX AI conference in Las Vegas? In this quick-hit episode, Rich shares his firsthand experience at the inaugural event. Offering a candid critique of the conference format and content, highlighting the hyper-focus on security and AI-powered development while noting a lack of truly groundbreaking insights. Ri…
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Stopping oral anticoagulation after AF ablation, the core problem with paradoxes like the smoker’s paradox, chronic total occlusion PCI, and an ACC/EHRA preview are discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medsca…
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AI Security: Building a Gold Standard for Your Organization
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26:43How secure is your AI? In this episode, we dive into the critical aspects of AI security and compliance, exploring the fundamental shift in security thinking required when integrating AI agents into your business. Discussing the transition from traditional "castle" security to a "hotel" model, emphasizing the need for granular access control and st…
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A large trial in cardiac pacing finally published, PVCs and cardiomyopathy, cannabis, CV risk and the danger of observational studies, and the tale of two disparate statin trials are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment,…
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Is SaaS Dead? The Rise of AI-First Software Development
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33:24Is SaaS dead? The era of traditional SaaS is being redefined by AI. In this episode, we explore the transformative impact of AI on the software industry and discuss the future of SaaS in an AI-first world. We dive into the potential for AI to revolutionize app development, disrupt traditional business models, and empower entrepreneurs with groundbr…
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Listener feedback, resistant hypertension, K-binders for MRA use in heart failure, nutritional epidemiology, and a positive study for vitamin D are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/tw…
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AI's Next Chapter: Grok 3, OpenAI, and the Path Forward
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26:57The AI world is abuzz with exciting new developments! In this episode, we discuss the latest AI news, including the groundbreaking Grok 3 release from XAI. We explore its potential impact on the AI landscape, the shift towards inference-based models, and the implications for companies like Google, Microsoft, and OpenAI. Join us as we analyze the ex…
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Listener feedback on asymptomatic aortic stenosis (AS), transcatheter aortic valve replacement (TAVR) vs surgical aortic valve replacement (SAVR), coronary artery calcium (CAC), and revascularization for patients with ischemic LV dysfunction are discussed by John Mandrola, MD, in today's podcast. This podcast is intended for healthcare professional…
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Top 4 AI Agents to Boost Your Business Profits
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29:59Want to unlock the power of AI to supercharge your business profits? In this episode, we explore the top 4 AI agents that can revolutionize your sales, customer support, and marketing efforts. Discover how these intelligent agents can automate tasks, improve efficiency, and drive revenue growth. We'll delve into the specific use cases for each agen…
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The treatment of asymptomatic aortic stenosis, the move to composite endpoints in trials, IFR vs FFR and high-frequency low tidal volume ventilation for AF ablation are the topics John Mandrola, MD, discusses in today's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://ww…
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The Future of Web Browsing: AI Agents and Automation
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22:05Ever wondered how AI is changing the way we browse the web? In this episode, we explore OpenAI's latest release, Operator, an AI agent that can surf the web and perform tasks on your behalf. We'll discuss its capabilities, potential use cases, and how businesses can leverage it to automate tasks, conduct research, and improve efficiency. Discover h…
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Blanking period after AF ablation, periprocedural MI after PCI in non-STEMI, predicting AF after ischemic stroke, and the proper standards for mitral valve repair in primary mitral regurgitation are the topics John Mandrola, MD, discusses in today’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or…
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Ever wondered if AI models really matter? In this episode, we explore the evolving landscape of AI models, discussing their commoditization, specialization, and the growing importance of reasoning and inference. We'll delve into the differences between various models, such as OpenAI's GPT-3 and DeepSeek, and how they are being used to power a wide …
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Silent cerebral embolism after LAAC, AI in ECG rhythm analysis, anti-thrombotic strategies in patients with AF and CAD, and subclinical AF are the topics John Mandrola, MD, covers in today’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Silent…
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Ever wondered how AI is disrupting the events and media industry? In this episode, we explore the transformative impact of AI with Heather Holst-Knudsen, President & CEO of H2K Labs and host of the upcoming Revved Up conference. Discover how AI is reshaping content creation, audience engagement, and revenue generation in the information and data ec…
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Sugar-sweetened beverages, the epidemiology of driving after an ICD, BP measurements, and massive EBM lesson in EVT for acute stroke are the topics John Mandrola, MD, discusses in today's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Sugar-Swe…
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Revving Up with AI: Transforming Auto Dealerships
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32:32How is AI transforming the auto dealership industry? In this episode, we explore the ways AI can revolutionize sales, enhance service department efficiency, and improve customer experiences. We'll discuss the challenges dealerships face, such as speed to lead and personalized communication, and how AI can provide solutions. Discover how AI is drivi…
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