This podcast delivers Dr. John Mandrola’s summary and perspective on top news of the week that cardiologists can’t miss. This podcast is intended for US health professionals only.
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Expertcommentary Podcasts
Welcome to "The AI Guys" podcast! Join hosts Lee Dickson and Rich Swier as they take you on a journey through the world of AI. In this episode, they share their personal journeys and experiences in the tech world. From discussing the parallels between the rise of the internet and AI, to exploring practical and technical aspects, Lee and Rich aim to make AI accessible and easy to understand for entrepreneurs, business owners, and the everyday consumer. With candid conversations and expert ins ...
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The Bob Harrington Show is a podcast series of thoughtful interviews and discussions on topics at the core of cardiology and the practice of medicine.
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Join Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, as they interview experts on the hottest topics in healthcare ranging from COVID-19 to social determinants of health to bringing humanity back to medicine.
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The Education Elephant: A Blueprint for AI in a Slow-to-Change Industry
39:50
39:50
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39:50Are you struggling to implement AI in a traditionally slow-to-change industry? Ed Buckley and Marlee Strawn, co-founders of Scholar Education, a platform using AI to transform learning, reveal their strategy for winning over skeptical teachers by co-designing a solution that reduces workload and personalizes student support. Learn how they're tackl…
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The big beta-blocker story from ESC, dual pathway therapy with aspirin and OAC, stopping OAC after successful AF ablation, and DANCAVAS II trial are the topics John Mandrola, MD, discusses on this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/t…
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Don't Get Burned: How to Prevent Your Project from Failing Before It Starts
31:33
31:33
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31:33Is your company's AI project spiraling out of control? Many organizations get excited and push for rapid development, but without proper governance, a solid plan, and a focus on core problems, these projects can spread like a virus. They lead to chaotic development, wasted spending, and developer burnout. We discuss why a "build versus buy" mentali…
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CAC 0 takes a gut punch, ICD therapies cannot be surrogates for benefit, and two important trials from ESC are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I CAC 0 LDL-C and CVD Risk With CA…
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Why Most AI Projects Fail Before They Start
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33:38
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33:38Ever wonder why so many AI projects fail? In this episode, Rich and Lee expose the "missing middle" of AI—the intensive data science work that happens between collecting your data and getting real value from it. They share three foundational laws of AI that challenge common misconceptions. Learn why a large investment isn't the key to success and h…
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John Mandrola discusses conduction system pacing vs standard pacing, withdrawing HF meds when AF is corrected and patient selection in LAAO. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Conduction System Pacing CSPACE trial https://doi.org/10.1016/j.ja…
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The Crucial Gap Between New AI Models and Your Business
28:12
28:12
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28:12Are new AI models like Grok 4 and ChatGPT-5 a game-changer for your business? This episode reveals that while the technology is advancing at a blistering pace, a significant cultural lag in human adoption is creating a disconnect. We break down why upgrading models isn't like upgrading software and how a "social media hangover" is hindering effecti…
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Big new hypertension guidelines, ultraprocessed foods, coronary sinus reduction and evidence-based medicine, and more news on pulsed field ablation for atrial fibrillation are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:…
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How to Overcome Your Team's Fear of Failure
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42:29
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42:29Are your executives stressed about AI? Many companies face "analysis paralysis," fearing a high-stakes, overnight transformation. We're joined by Kurt Daniel, a 25-year software veteran and former Microsoft alum, who argues for a balanced approach. He shares how to create psychological safety for your team, encouraging them to experiment and even f…
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Listener feedback on SURPASS CVOT, AF ablation and the limits of meta-analyses, a Watchman alert from FDA, and oral anticoagulation choices in elderly patients are discussed by John Mandola, MD, in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape…
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Tools vs. Autonomous Agents - The Crucial Difference Explained
37:51
37:51
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37:51Are you struggling to scale your AI efforts beyond single-user tools? Many businesses confuse basic AI applications with robust, autonomous AI agents, leading to significant limitations. This episode dissects the critical differences between AI tools and agent platforms, revealing why security, scalability, and centralized management are vital for …
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Exercise and CV outcomes, aldosterone modulation, AI for ECG reading, GLP-1 comparisons, end-of-life decisions, and another well-meaning policy that caused harm in veterans are discussed by John Mandrola, MD, in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https:…
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Are you confusing AI with simple automation? Many businesses struggle to differentiate between AI layers and workflow automation, hindering their true AI potential. This episode dissects the "new stack," revealing how applications must be AI-ready, built with AI, and centered on a conversational user experience. Discover the critical middleware tha…
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The VENTOUX study of endurance athletes, the 10,000 step myth was not busted, rate vs rhythm control for AF, and GLP1 drugs and observational studies are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.…
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No Going Back: The AI Revolution in Higher Education
32:29
32:29
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32:29Worried about AI in education? This episode features Jen Gillespie, an assistant professor redesigning her psychology courses at the University of South Florida to intentionally integrate AI. She shares her strategy for ethical AI use, focusing on transparent collaboration and proper citation. Discover how she guides students to use AI as a powerfu…
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Finerenone, what not to consider when choosing treatment of AS, brain health after atrial fibrillation ablation, early rhythm control for AF, and Watchman reimbursement cuts are discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https…
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Your AI Agent is Failing: Is Your Language Model To Blame?
19:50
19:50
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19:50Are your AI solutions underperforming? Many businesses struggle with AI model selection, leading to wasted resources and poor results. This episode reveals the critical factors—use case, speed, and cost—that determine the right language model for your specific needs. Discover why a single AI model isn't enough and how strategic model integration ca…
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Approval of first-generation devices, the ticagrelor controversy, ICD longevity, the PRAGUE-25 trial (one of the most important trials of the year), and some thoughts on the end of EP as a profession are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial tran…
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FDA approves triple-drug polypill, a change of opinion, a deep dive into invasive pulmonary embolism therapies, heart disease trends, and diabetes care is on fire are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://…
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Academic Entrepreneurship Key for Clinician Researchers Given NIH Funding Uncertainty
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25:27Bob Harrington chairs a panel with two early-career physician researchers and the head of a large research institute on what the future holds in lights of NIH funding cuts. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington You may also like: Hear John…
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CEO AI Mindset: Hitting the Wall with ROI?
31:32
31:32
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31:32Are C-suite executives truly ready for the AI revolution, or are they stuck in old ways of thinking? In this episode we dive into a revealing new survey exploring CEO mindsets on AI. We uncover the surprising disconnects between high-level expectations and actual ROI, examining why so many AI initiatives fail to scale beyond pilot mode. Confronting…
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A big, deep dive into CTA and fractional flow reserve CT, and a sobering report on the new EVOQUE valve are discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback and Correction CRAAFT HF …
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Make Your Brand AI-Ready: The Soul of AI Marketing
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27:18
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27:18Is your brand truly ready for the AI revolution? This episode dives deep into making AI your next true brand asset. We explore how to infuse your company's unique culture and messaging into AI models, transforming them from mere tools into powerful, human-like brand ambassadors. Discover how recording internal meetings and customer interactions can…
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Listener feedback on cardiac sarcoidosis, SA node ablation, surgical AF ablation, chronic kidney disease protection, and recruiting for clinical trials are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscap…
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AI & Education: The Personalized Learning Revolution
24:51
24:51
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24:51Tired of education that leaves too many behind? In this episode, we ignite a passionate discussion about the revolutionary potential of AI to personalize learning and transform education. We talk about how AI can finally address the limitations of one-size-fits-all schooling, offering a beacon of hope for engaging individual interests and fostering…
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Listener feedback on cardiac sarcoidosis, out-of-hospital cardiac arrest, less is more when it comes to post-stent antiplatelets, lipoprotein(a), and atrial fibrillation in HFpEF are discussed by John Mandrola, MD, in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: …
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Are You Ready for the AI Stack Revolution?
25:43
25:43
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25:43The old rules of software are breaking down! In this electrifying episode, we ignite a crucial conversation about the "new AI stack": a revolutionary paradigm poised to dethrone traditional software development and SaaS as we know it. Feel the urgency as we explore how an "AI-first" mentality is no longer a futuristic fantasy but a present-day impe…
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Listener feedback, CRT vs CSP, important clues on the ECG, beta-blocker interruption after myocardial infarction, novel approaches to LDL-C lowering, and ICD decisions in cardiac sarcoidosis are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or…
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AI Voice: Ready for Business or Still Hype?
21:53
21:53
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21:53Is AI voice finally ready for business? In this episode, we dive into the current landscape and future potential of AI voice technology. We explore the advancements in creating natural-sounding voices with minimal latency, unlocking new use cases beyond simple text-to-speech. From enhancing customer support and streamlining outbound communication t…
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Listener feedback on sports “disqualification,” big digoxin news, Brugada syndrome, another positive finerenone study, and unblinded transcatheter trials are discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/…
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Finding Your AI Soulmate: The Key to a Perfect Partnership
23:05
23:05
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23:05Feeling lost in the complex world of AI, unsure who to trust with your future? Finding the perfect AI partner is crucial for long-term success. In this episode, we unveil the crucial secret to AI success: finding the right partner. We go beyond the tech and explore the essential qualities of a strategic AI collaborator who can guide you towards an …
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The BedMed trial of nighttime BP meds, SURMOUNT-5, Troponin URL, gene tests in patients with no disease, and guideline-directed medical therapy for HF are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape…
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The Real Cost of AI: Understanding Your Investment and ROI
28:10
28:10
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28:10Thinking about investing in AI for your business but unsure of the real cost and potential returns? In this episode, we cut through the complexity to deliver a clear understanding of AI cost calculations and the path to significant ROI. Breaking down the investment required for both basic AI tools and scalable Agentic Workforces, revealing the key …
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