Abstract: This article examines how evidence-based neuroscience principles can be leveraged to develop learning agility in organizational leaders. Learning agility—the ability to quickly adapt, learn from experience, and apply new knowledge in changing situations—has become a crucial leadership capability in volatile business environments. Drawing on recent neuroscience research, this paper identifies key brain mechanisms involved in learning agility and translates these insights into practical strategies. The discussion covers neuroplasticity foundations, attention network optimization, stress regulation techniques, and social brain activation approaches. Organizations implementing these neuroscience-informed practices have seen measurable improvements in leadership adaptability, innovation capacity, and organizational resilience. The paper provides a framework for sustainable learning agility development through integrating neuroscience principles into leadership development programs, feedback systems, and organizational learning cultures.