Abstract: Organizations are experiencing profound shifts in how productive knowledge is created, stored, shared, and leveraged amidst changing work patterns. This research-based article examines the restructuring of organizational knowledge ecosystems in response to hybrid work, technological disruption, and evolving workforce expectations. Drawing on recent empirical studies and organizational cases, it analyzes the consequences of knowledge fragmentation and presents evidence-based interventions to strengthen knowledge continuity. The analysis reveals that organizations implementing structured knowledge management approaches—including digital knowledge architecture, collaborative documentation practices, and intentional knowledge transfer mechanisms—demonstrate greater operational resilience and innovation capacity. The article concludes with a framework for building long-term knowledge capabilities through organizational learning systems, knowledge governance structures, and strategic talent practices that preserve critical expertise while adapting to emergent work models.