Abstract: This research brief examines how generative artificial intelligence, large language models, and machine learning are fundamentally reshaping work across industries. The analysis explores AI's shift from task automation to cognitive augmentation, highlighting its implications for workforce skills, organizational strategy, and competitive advantage. Drawing on current research and industry examples from healthcare, manufacturing, and professional services, the brief identifies emerging work paradigms and offers practical implementation guidance for organizations navigating this transformation. Key themes include the importance of human-AI integration, strategic capability building, and ethical governance frameworks. The author argues that successful organizations will be those that leverage AI not merely for efficiency but as a catalyst for business model innovation while creating work environments that amplify distinctly human capabilities—ultimately suggesting that the AI revolution represents both unprecedented opportunity and significant challenge for today's leaders.