Abstract: This article examines how the evolving geography of work is reshaping organizational structures and regional economic resilience. The COVID-19 pandemic accelerated existing trends toward remote and hybrid work arrangements, creating a fundamental shift in where and how work occurs. Drawing on recent research in organizational science, economic geography, and regional studies, this analysis explores the implications of distributed work models for both organizational performance and regional economic development. The article identifies evidence-based strategies that forward-thinking organizations are employing to build adaptive capacity while contributing to place-based resilience. Key interventions include location-agnostic talent strategies, hub-and-spoke operational models, and collaborative place-making initiatives. The findings suggest that organizations which successfully navigate this new geography can simultaneously enhance their competitive positioning and strengthen the socioeconomic fabric of their communities.