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EP 215: Vectorized RNAi and the next frontier of gene silencing with Rachel Salzman of Armatus Bio
Manage episode 521473481 series 2631947
Content provided by Sano Genetics. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Sano Genetics or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Summary:
This week on The Genetics Podcast, Patrick is joined by Dr. Rachel Salzman, CEO of Armatus Bio. They discuss the promise of vectorized RNAi for autosomal dominant diseases, the key scientific and clinical hurdles in gene therapy, and Rachel’s lessons from two decades in the field.
Show Notes:
0:00 Intro to The Genetics Podcast
01:00 Welcome to Rachel
01:35 Background of Armatus Bio and the mechanism behind its vectorized RNAi platform
05:31 Advantages of vectorized RNAi over conventional RNAi approaches
08:07 How microRNAs work and how engineered versions enable highly specific gene silencing
10:28 Current preclinical progress at Armatus and next steps toward first-in-human trials
14:06 Lessons on making smart risk decisions in rare disease drug development
17:26 Reflections on two decades of progress, setbacks, and realities in gene therapy
22:07 Hemophilia as a case study in gene therapy missteps and overlooked patient and market realities
25:21 Challenges around product purity and the need for financial innovation
29:23 Why AAV purity is so difficult to achieve and where pre-competitive collaboration could drive improvement
33:32 Rachel’s path from veterinary medicine to gene therapy through a family genetic diagnosis
35:58 Founding the Stop ALD Foundation and advancing lentiviral gene therapy into first-in-human use
39:58 The future potential of vectorized RNAi
42:00 Closing remarks
Please consider rating and reviewing us on your chosen podcast listening platform!
https://drive.google.com/file/d/1Bp2_wVNSzntTs_zuoizU8bX1dvao4jfj/view?usp=share_link
218 episodes
Share
Manage episode 521473481 series 2631947
Content provided by Sano Genetics. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Sano Genetics or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Summary:
This week on The Genetics Podcast, Patrick is joined by Dr. Rachel Salzman, CEO of Armatus Bio. They discuss the promise of vectorized RNAi for autosomal dominant diseases, the key scientific and clinical hurdles in gene therapy, and Rachel’s lessons from two decades in the field.
Show Notes:
0:00 Intro to The Genetics Podcast
01:00 Welcome to Rachel
01:35 Background of Armatus Bio and the mechanism behind its vectorized RNAi platform
05:31 Advantages of vectorized RNAi over conventional RNAi approaches
08:07 How microRNAs work and how engineered versions enable highly specific gene silencing
10:28 Current preclinical progress at Armatus and next steps toward first-in-human trials
14:06 Lessons on making smart risk decisions in rare disease drug development
17:26 Reflections on two decades of progress, setbacks, and realities in gene therapy
22:07 Hemophilia as a case study in gene therapy missteps and overlooked patient and market realities
25:21 Challenges around product purity and the need for financial innovation
29:23 Why AAV purity is so difficult to achieve and where pre-competitive collaboration could drive improvement
33:32 Rachel’s path from veterinary medicine to gene therapy through a family genetic diagnosis
35:58 Founding the Stop ALD Foundation and advancing lentiviral gene therapy into first-in-human use
39:58 The future potential of vectorized RNAi
42:00 Closing remarks
Please consider rating and reviewing us on your chosen podcast listening platform!
https://drive.google.com/file/d/1Bp2_wVNSzntTs_zuoizU8bX1dvao4jfj/view?usp=share_link
218 episodes
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Similar to The Genetics Podcast
I discuss a variety of topics in both the natural and social sciences, exploring the many fascinating insights that the scientific method yields about the world around us.
…
continue reading
Whether the topic is popcorn or particle physics, you can count on BrainStuff to explore -- and explain -- the everyday science in the world around us.
…
continue reading
A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vineeta Agarwala, Julie Yoo, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg Verdine, Fei-Fei Li, and Suchi Saria, as they explore the i ...
…
continue reading
The Science Show gives Australians unique insights into the latest scientific research and debate, from the physics of cricket to prime ministerial biorhythms.
…
continue reading
We take a critter’s eye view to explore how animal behavior parallels humans. Join comedians and science-lovers as we get inside the minds of animals
…
continue reading
The kickass science and technology radio show that delivers an irreverent look at the week in science and technology.
…
continue reading
When you hear the words Alzheimer's disease, what do you think of? The truth is, the picture most of us have of the disease is incomplete. Alzheimer's disease doesn't start when someone starts to lose their memory. It actually starts years – sometimes decades – earlier. The Rethinking Alzheimer's Disease Podcast is an engaging, narrative-style podcast miniseries for those curious or motivated to learn about Alzheimer’s disease. Perhaps you have a family member with Alzheimer’s disease, or ca ...
…
continue reading
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
continue reading
How many organs could you donate and remain alive? How many planet Earths could fit inside the Sun? How high is a giraffe's blood pressure? Why is the sea blue? To find out, Ask The Naked Scientists!
…
continue reading
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…
continue reading
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