Induced pluripotent stem cells (iPSCs) are a mind-blowing scientific advancement—one of many that make it possible for n-Lorem to do what we do. In short, typical skin cells are taken from an individual and chemically induced over time to grow into any cell type in the body, like muscle and liver cells. You can do that? Yes, and we do! The most common cell type that we use at n-Lorem are neurons (nerve cells). These cells are not easily accessible in living humans without serious surgeries and that is why scientists instead use iPSCs to grow them.

On This Episode We Discuss:
1:23 - What are Induced Pluripotent Stem Cells?
5:45 - Chromatin – compressed DNA and proteins
9:13 - Differentiation and de-differentiation
10:26 - Transcription and transcription factors
12:35 - Why are iPSCs important?
15:20 - Making iPSC and re-differentiating them into the cells we study is time consuming and expensive
Important Links:
n-Lorem 2025 Nano-rare Patient Colloquium - https://www.nlorem.org/nano-rare-patient-colloquium-2025/

Support nano-rare with a donation to n-Lorem: https://www.nlorem.org/donate/
Learn about Hongene Biotech: https://hongene.com/