What is the best treatment for advanced melanoma — and why do some therapies fail while others succeed?
In this episode of Outsmart Cancer, Dr. Dino Prato, founder of Envita Medical Centers, breaks down the future of melanoma care: deep mapping and immune-centered precision oncology. Using DNA, RNA, and spatial biology, Dr. Prato explains how mapping every pathway — not just BRAF mutations — gives doctors a full picture of the tumor’s environment, revealing why PD-1 inhibitors, BRAF/MEK drugs, and other standard therapies work for only a small group of patients.
The key to melanoma, he says, lies in natural killer (NK) cells. These immune cells, trained through AAIT (Autologous Adoptive Immunotherapy), can cross the blood-brain barrier and destroy tumor cells without the side effects of high-dose systemic drugs. By combining deep mapping, immune retraining, and microdosed precision therapies, Envita helps patients move from reactionary care to immune-guided treatment.
🎯 What You’ll Learn in This Episode:
• Why most standard melanoma treatments only help a small percentage of patients

• How DNA, RNA, and spatial biology mapping reveal hidden resistance pathways

• The difference between TIL therapy and AAIT (Autoglutid Adaptive Immunotherapy)

• How NK and dendritic cells are trained using DAMPs to target melanoma cells

• Why changing the tumor microenvironment is critical for immune response

• How AAIT avoids cytokine storms and side effects seen in other therapies
📍 Envita Medical Centers – Scottsdale, AZ
🌐 Learn more: https://www.envita.com
Disclaimer
This podcast is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your licensed healthcare provider before making any medical decisions. Individual results will vary, and Envita Medical Centers does not guarantee outcomes. Some treatments discussed may not be FDA-approved or available in all locations. Testimonials are shared with patient consent and may not reflect typical results. Do not delay or disregard professional medical care based on the podcast's content. Certain treatments may be available only at Envita’s international clinic in Hermosillo, Mexico. No specific outcomes are promised or implied.
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Outcomes Disclaimer
The results referenced from Envita's Precision Cancer Care: 35-Fold Improvement in Response Rates are from a retrospective analysis of 199 late-stage cancer patients treated at Envita Medical Centers between 2021 and 2023, as published in the Journal of Cancer Therapy. These outcomes are not guaranteed and will vary based on individual factors such as cancer type, stage, genetics, immunity and prior treatments. Any comparisons to standard care or clinical trials are based on published data and internal analysis, not head-to-head studies. Individual results will vary.

You can read the full peer-reviewed study at:

https://www.scirp.org/journal/paperinformation?paperid=132493