Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
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Psychedelics & Cerebral Cortex: Neuroplasticity, Psilocybin, Ketamine | Alex Kwan | 226
Manage episode 480026954 series 2846067
Content provided by Nick Jikomes. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Nick Jikomes or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Short Summary: Dr. Alex Kwan unpacks the latest neuroscience research on how psychedelics like ketamine & psilocybin reshape the brain.
About the guest: Alex Kwan, PhD, is an associate professor of biomedical engineering at Cornell University. His lab employs advanced imaging to study how psychedelics and other drugs affect the mammalian brain.
Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.
Episode Summary: Dr. Alex Kwan discusses how psychedelics like ketamine and psilocybin induce rapid neuroplastic changes in the brain, particularly in the prefrontal cortex, contrasting their effects with traditional antidepressants like SSRIs, and exploring their potential for treating depression and chronic pain through structural and functional brain alterations.
Key Takeaways:
- Ketamine & psilocybin rapidly increase dendritic spine density in the prefrontal cortex, enhancing neural connections within days, unlike SSRIs, which take weeks.
- These drugs show sustained neuroplastic changes in mice, lasting weeks to months after a single dose, suggesting long-term brain rewiring.
- Serotonin 2A receptor is critical for psilocybin’s neuroplastic effects, as precise genetic knockouts in adult mice eliminate spine growth.
- Unlike ketamine, psilocybin activates the insula, a brain region linked to chronic pain processing, hinting at new therapeutic potential.
- Both drugs induce similar gene expression patterns in areas like the prefrontal cortex and amygdala, but differ in specific regions like the insula.
Related episode:
- M&M #30: Psilocybin, Ketamine, Neuroplasticity & Imaging the Brain | Alex Kwan
*Not medical advice.
All episodes, show notes, transcripts, and more at the M&M Substack
Affiliates:
- KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime)
- Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off
- Readwise: Organize and share what you read. 60 days FREE through link
- SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount.
- MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off
For all the ways you can support my efforts
Chapters
1. Intro (00:00:00)
2. Cerebral Cortex Structure (00:04:32)
3. Excitatory vs. Inhibitory Neurons (00:09:00)
4. Depression & Neuroplasticity (00:14:20)
5. SSRI Effects & Limitations (00:19:19)
6. Ketamine & Psilocybin Rapid Effects (00:24:34)
7. Dendritic Spine Plasticity (00:30:00)
8. Serotonin 2A Receptor Debate (00:36:01)
9. Ketamine vs. Psilocybin Mechanisms (00:41:32)
10. Measuring Psychedelic Effects in Mice (00:46:08)
11. Head Twitch Response Limitations (00:52:13)
12. Serotonin 2A Receptor Knockout Results (00:57:10)
13. c-Fos Mapping Insights (01:03:19)
14. Future Research Directions (01:09:28)
237 episodes
Share
Manage episode 480026954 series 2846067
Content provided by Nick Jikomes. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Nick Jikomes or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Short Summary: Dr. Alex Kwan unpacks the latest neuroscience research on how psychedelics like ketamine & psilocybin reshape the brain.
About the guest: Alex Kwan, PhD, is an associate professor of biomedical engineering at Cornell University. His lab employs advanced imaging to study how psychedelics and other drugs affect the mammalian brain.
Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.
Episode Summary: Dr. Alex Kwan discusses how psychedelics like ketamine and psilocybin induce rapid neuroplastic changes in the brain, particularly in the prefrontal cortex, contrasting their effects with traditional antidepressants like SSRIs, and exploring their potential for treating depression and chronic pain through structural and functional brain alterations.
Key Takeaways:
- Ketamine & psilocybin rapidly increase dendritic spine density in the prefrontal cortex, enhancing neural connections within days, unlike SSRIs, which take weeks.
- These drugs show sustained neuroplastic changes in mice, lasting weeks to months after a single dose, suggesting long-term brain rewiring.
- Serotonin 2A receptor is critical for psilocybin’s neuroplastic effects, as precise genetic knockouts in adult mice eliminate spine growth.
- Unlike ketamine, psilocybin activates the insula, a brain region linked to chronic pain processing, hinting at new therapeutic potential.
- Both drugs induce similar gene expression patterns in areas like the prefrontal cortex and amygdala, but differ in specific regions like the insula.
Related episode:
- M&M #30: Psilocybin, Ketamine, Neuroplasticity & Imaging the Brain | Alex Kwan
*Not medical advice.
All episodes, show notes, transcripts, and more at the M&M Substack
Affiliates:
- KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime)
- Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off
- Readwise: Organize and share what you read. 60 days FREE through link
- SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount.
- MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off
For all the ways you can support my efforts
Chapters
1. Intro (00:00:00)
2. Cerebral Cortex Structure (00:04:32)
3. Excitatory vs. Inhibitory Neurons (00:09:00)
4. Depression & Neuroplasticity (00:14:20)
5. SSRI Effects & Limitations (00:19:19)
6. Ketamine & Psilocybin Rapid Effects (00:24:34)
7. Dendritic Spine Plasticity (00:30:00)
8. Serotonin 2A Receptor Debate (00:36:01)
9. Ketamine vs. Psilocybin Mechanisms (00:41:32)
10. Measuring Psychedelic Effects in Mice (00:46:08)
11. Head Twitch Response Limitations (00:52:13)
12. Serotonin 2A Receptor Knockout Results (00:57:10)
13. c-Fos Mapping Insights (01:03:19)
14. Future Research Directions (01:09:28)
237 episodes
All episodes
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Similar to Mind & Matter
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
continue reading
A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
…
continue reading
You Are Not So Smart is a show about psychology that celebrates science and self delusion. In each episode, we explore what we've learned so far about reasoning, biases, judgments, and decision-making.
…
continue reading
As She Rises brings together local poets and activists from throughout North America to depict the effects of climate change on their home and their people. Each episode carries the listener to a new place through a collection of voices, local recordings and soundscapes. Stories span from the Louisiana Bayou, to the tundras of Alaska to the drying bed of the Colorado River. Centering the voices of native women and women of color, As She Rises personalizes the elusive magnitude of climate cha ...
…
continue reading
Going Wild with Dr. Rae Wynn Grant is a different kind of nature show about the human drama of saving animals. From a paleoanthropologist who hunts fossils in conflict zones to someone who helped save an endangered species while in prison, in season four we will hear from real-life heroes and nature advocates with widely different expertise and life experiences that led them to be champions for the natural world. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals i ...
…
continue reading
Travel, at its best, changes the way we see the world. Join us each week as we dig into stories from people who took a trip—and came home transformed. Travel Tales by Afar is your ticket to the world, no passport required.
…
continue reading
In each episode, we talk with inspiring scientists, thinkers, and other self-actualized individuals who will give you a greater understanding of yourself, others, and the world we live in. Scott Barry Kaufman explores the depths of human potential and tries to get a glimpse into human possibility in every episode.
…
continue reading
All In The Mind is ABC RN's weekly podcast looking into the mental universe, the mind, brain and behaviour — everything from addiction to artificial intelligence.
…
continue reading
The kickass science and technology radio show that delivers an irreverent look at the week in science and technology.
…
continue reading
Whether the topic is popcorn or particle physics, you can count on BrainStuff to explore -- and explain -- the everyday science in the world around us.
…
continue reading
Player FM - Podcast App
Go offline with the Player FM app!
Go offline with the Player FM app!
