You Are Not So Smart is a show about psychology that celebrates science and self delusion. In each episode, we explore what we've learned so far about reasoning, biases, judgments, and decision-making.
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Fructose, Microglia, Anxiety & Brain Development | Justin Perry | 249
Manage episode 504180120 series 2846067
Content provided by Nick Jikomes. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Nick Jikomes or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Cellular clean up by immune cells and how early-life fructose exposure leads to neurodevelopmental problems.
Episode Summary: Dr. Justin Perry talks about the body's constant cellular turnover—about 3 million cells die per second in adults (double in children and women)—handled by phagocytes like macrophages that engulf and digest debris to prevent diseases like lupus. They explore phagocytosis steps, macrophage adaptations in tissues like the brain (microglia), and how high fructose intake impairs microglial function in developing mice, leading to uncleared brain cells and anxiety-like behaviors, with implications for human neurodevelopmental disorders amid rising fructose consumption.
About the guest: Justin Perry, PhD is an immunologist and clinical psychologist who leads a lab at Memorial Sloan Kettering Cancer Center focusing on how the body clears dead cells and debris to maintain homeostasis.
Discussion Points:
- The body turns over 1-2% of its 30 trillion cells daily, mostly blood cells, but neurons in kids and endometrium in women turnover at ~2x this rate
- Phagocytosis involves "find me," "eat me," and digestion signals; failures can cause autoimmunity.
- Microglia are brain macrophages that uptake fructose via GLUT5 transporter.
- Early high fructose exposure (comparable to one soda daily) impairs the pruning of synapses and dead neurons.
- In mice, prenatal or postnatal fructose causes phagocytosis deficits in the prefrontal cortex, leading to heightened fear responses and poor fear extinction, mimicking anxiety disorders.
- Fructose correlates with rising neurodevelopmental issues like autism and anxiety; it's passed via breast milk, and liquid forms (e.g., sodas) overwhelm metabolic shields more than solid fruits.
- Macrophages may hold keys to diseases from atherosclerosis to cancer; deleting GLUT5 in microglia reverses fructose's effects, hinting at evolutionary roles in aging or low-oxygen states.
Related content:
- M&M 215: Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary Patti
- Article | Dietary Fructose & Metabolic Health: An Evolutionary Perspective
Reference Paper:
- Study | Early life high fructose impairs microglial phagocytosis and neurodevelopment
*Not medical advice.
Affiliates:
- Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.
- KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)
- Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off
- SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount.
For all the ways you can support my efforts
265 episodes
Share
Manage episode 504180120 series 2846067
Content provided by Nick Jikomes. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Nick Jikomes or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Cellular clean up by immune cells and how early-life fructose exposure leads to neurodevelopmental problems.
Episode Summary: Dr. Justin Perry talks about the body's constant cellular turnover—about 3 million cells die per second in adults (double in children and women)—handled by phagocytes like macrophages that engulf and digest debris to prevent diseases like lupus. They explore phagocytosis steps, macrophage adaptations in tissues like the brain (microglia), and how high fructose intake impairs microglial function in developing mice, leading to uncleared brain cells and anxiety-like behaviors, with implications for human neurodevelopmental disorders amid rising fructose consumption.
About the guest: Justin Perry, PhD is an immunologist and clinical psychologist who leads a lab at Memorial Sloan Kettering Cancer Center focusing on how the body clears dead cells and debris to maintain homeostasis.
Discussion Points:
- The body turns over 1-2% of its 30 trillion cells daily, mostly blood cells, but neurons in kids and endometrium in women turnover at ~2x this rate
- Phagocytosis involves "find me," "eat me," and digestion signals; failures can cause autoimmunity.
- Microglia are brain macrophages that uptake fructose via GLUT5 transporter.
- Early high fructose exposure (comparable to one soda daily) impairs the pruning of synapses and dead neurons.
- In mice, prenatal or postnatal fructose causes phagocytosis deficits in the prefrontal cortex, leading to heightened fear responses and poor fear extinction, mimicking anxiety disorders.
- Fructose correlates with rising neurodevelopmental issues like autism and anxiety; it's passed via breast milk, and liquid forms (e.g., sodas) overwhelm metabolic shields more than solid fruits.
- Macrophages may hold keys to diseases from atherosclerosis to cancer; deleting GLUT5 in microglia reverses fructose's effects, hinting at evolutionary roles in aging or low-oxygen states.
Related content:
- M&M 215: Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary Patti
- Article | Dietary Fructose & Metabolic Health: An Evolutionary Perspective
Reference Paper:
- Study | Early life high fructose impairs microglial phagocytosis and neurodevelopment
*Not medical advice.
Affiliates:
- Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.
- KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)
- Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off
- SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount.
For all the ways you can support my efforts
265 episodes
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Similar to Mind & Matter
You Are Not So Smart is a show about psychology that celebrates science and self delusion. In each episode, we explore what we've learned so far about reasoning, biases, judgments, and decision-making.
…
continue reading
Interviews with Anthropologists about their New Books Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/anthropology
…
continue reading
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
continue reading
Join expert voices from Barbell Logic and others from the world of strength for resources to help you get strong for life. Get coaching options and more educational content at barbell-logic.com.
…
continue reading
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…
continue reading
All In The Mind is ABC RN's weekly podcast looking into the mental universe, the mind, brain and behaviour — everything from addiction to artificial intelligence.
…
continue reading
The Unshakeables podcast from Chase for Business and iHeartMedia's Ruby Studio dives into the unbelievable “What are we gonna do now?” moments that changed everything for small business owners. From mom-and-pop coffee shops to auto-detailing garages, every small business owner knows that the journey is full of the unexpected. A single make-or-break experience can change the course of your business forever. Those who stand firm in their resolve have a special name. We call them The Unshakeabl ...
…
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In each episode, we talk with inspiring scientists, thinkers, and other self-actualized individuals who will give you a greater understanding of yourself, others, and the world we live in. Scott Barry Kaufman explores the depths of human potential and tries to get a glimpse into human possibility in every episode.
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There are a lot of fads, blogs and strong opinions, but then there’s SCIENCE. Science Vs is the show from Spotify Studios that finds out what’s fact, what’s not, and what’s somewhere in between. We do the hard work of sifting through all the science so you don't have to and cover everything from 5G and ADHD, to Fluoride and Fasting Diets.
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continue reading
How terrifying would it be to fight an unknown enemy? One you don’t recognize and didn’t see coming? What if that enemy was coming from within; a disease that even doctors couldn’t identify? Nearly half of all Americans suffer from some chronic illness and many struggle for an accurate diagnosis. Every other week on Symptomatic, host Lauren Bright Pacheco unravels the medical mystery of a patient’s baffling symptoms and explores how their lives were turned upside down in search of answers. F ...
…
continue reading
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