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Are Mood Disorders Actually Metabolic Diseases Rooted in Insulin Resistance?

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Manage episode 517514028 series 1582679
Content provided by Briana Mercola and Dr. Mercola. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Briana Mercola and Dr. Mercola or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
  • Bipolar disorder and depression affect tens of millions globally, long treated as strictly brain-based illnesses, yet both consistently show high rates of insulin resistance and metabolic disturbances
  • A 2025 Nature Neuroscience study found that pancreatic insulin release and hippocampal activity are linked through a circadian feedback loop. This suggests bipolar mood shifts arise from disrupted metabolism, not brain chemistry alone
  • Earlier research in 2022 showed lithium stabilizes mood partly by restoring insulin signaling, while a clinical trial found metformin improved both insulin sensitivity and psychiatric symptoms in treatment-resistant bipolar depression patients
  • Insulin resistance is extremely widespread, with around 40% of Americans affected, driven by refined sugars, seed oils, stress, sleep loss, and environmental exposures that disrupt the body's natural energy regulation
  • Supporting insulin sensitivity involves stepwise changes, replacing damaged fats and ultraprocessed foods, introducing gut-friendly carbs and fibers gradually, managing stress, improving sleep, and staying active to stabilize both metabolic and mental health
  continue reading

1016 episodes

Artwork
iconShare
 
Manage episode 517514028 series 1582679
Content provided by Briana Mercola and Dr. Mercola. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Briana Mercola and Dr. Mercola or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
  • Bipolar disorder and depression affect tens of millions globally, long treated as strictly brain-based illnesses, yet both consistently show high rates of insulin resistance and metabolic disturbances
  • A 2025 Nature Neuroscience study found that pancreatic insulin release and hippocampal activity are linked through a circadian feedback loop. This suggests bipolar mood shifts arise from disrupted metabolism, not brain chemistry alone
  • Earlier research in 2022 showed lithium stabilizes mood partly by restoring insulin signaling, while a clinical trial found metformin improved both insulin sensitivity and psychiatric symptoms in treatment-resistant bipolar depression patients
  • Insulin resistance is extremely widespread, with around 40% of Americans affected, driven by refined sugars, seed oils, stress, sleep loss, and environmental exposures that disrupt the body's natural energy regulation
  • Supporting insulin sensitivity involves stepwise changes, replacing damaged fats and ultraprocessed foods, introducing gut-friendly carbs and fibers gradually, managing stress, improving sleep, and staying active to stabilize both metabolic and mental health
  continue reading

1016 episodes

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