BLA 145: Why Most Statin Side Effects Are Not What You Think...

Building Lifelong Athletes

Content provided by Jordan Rennicke, MD, Jordan Rennicke, and MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Jordan Rennicke, MD, Jordan Rennicke, and MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

11d ago 39:57

MP3•Episode home

Are statin side effects like muscle aches and brain fog as common as you've heard? In this deep dive, I break down the real data on statin intolerance, explain the powerful "nocebo effect" (where negative expectations cause real symptoms), and walk you through the exact management strategies we use in clinic. We'll also cover all the non-statin alternatives available today, giving you a complete, evidence-based framework for this important conversation.

Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life.

➡️ Download Here: https://www.jrennickemd.com/necessaryninepdf

CHAPTERS:
00:00 - Intro
01:14 - The Statin Paradox
02:42 - Statin Intolerance Definition
03:45 - The “Two Statin” Rule
05:03 - Complete vs Partial Intolerance
06:58 - Prevalence
08:26 - The Spectrum of Statin Side Effects
08:58 - Statin Associated Muscle Symptoms (SAMS)
11:12 - Why SAMS Occur
14:29 - Statin and Diabetes
17:30 - Statins and Brain Fog/Dementia
19:37 - Statins and the Liver
20:34 - The Nocebo Effect
21:56 - GAUSS-3 Trial
22:55 - SAMSON Trial
24:15 - The Power of Educating Patients
25:23 - Initial Patient Evaluation
27:49 - The “De-Challenge” Period
29:23 - Re-Challenging Patients
31:03 - Patient Education
32:24 - Non Statin Medications: Ezetimibe
33:38 - Non Statin Medications: PCSK9 inhibitors
34:32 - Non Statin Medications: Bempedoic Acid
35:35 - Non Statin Medications: Inclisiran
36:25 - Non Statin Medications: Comparison
37:19 - Key Takeaways
SELECTED REFERENCES:

Clinician use of the Statin Choice Shared Decision-making Encounter Tool in a Major Health System - PMC, accessed August 10, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC11255133/
Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients ..., accessed August 10, 2025, https://pubmed.ncbi.nlm.nih.gov/27039291/
2018 Guideline on the Management of Blood Cholesterol - American College of Cardiology, accessed August 10, 2025, https://www.acc.org/~/media/Non-Clinical/Files-PDFs-Excel-MS-Word-etc/Guidelines/2018/Guidelines-Made-Simple-Tool-2018-Cholesterol.pdf
Comparative Cardiovascular Benefits of Bempedoic Acid and Statin Drugs - JACC Journals, accessed August 10, 2025, https://www.jacc.org/doi/10.1016/j.jacc.2024.04.048
NLA Scientific Statement on Statin Intolerance: A New Definition and ..., accessed August 10, 2025, https://www.lipid.org/sites/default/files/files/Statin%20Intolerance%20A%20New%20Definition%20%26%20Key%20Considerations%20(JPP).pdf
Statin Intolerance | Circulation - American Heart Association Journals, accessed August 10, 2025, https://www.ahajournals.org/doi/10.1161/circulationaha.114.013189
Prevalence of statin intolerance: a meta-analysis | European Heart Journal | Oxford Academic, accessed August 10, 2025, https://academic.oup.com/eurheartj/article/43/34/3213/6529098
Statin Intolerance and Risk of Coronary Heart Events and All-Cause Mortality Following Myocardial Infarction - JACC Journals, accessed August 10, 2025, https://www.jacc.org/doi/10.1016/j.jacc.2016.12.036
Diagnosis and Management of Statin Intolerance - PMC, accessed August 10, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC6402887/
a new definition and key considerations for ASCVD risk reduction in the statin intolerant patient - PubMed, accessed August 10, 2025, https://pubmed.ncbi.nlm.nih.gov/35718660/
https://link.springer.com/article/10.1007/s11886-022-01729-x

*Disclaimer*

This podcast is for entertainment, education, and informational purposes only.
The topics discussed should not solely be used to diagnose, treat , or prevent any condition.
The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate.
Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

147 episodes

#Fitness #Medicine #Jordan Rennicke, MD #Jordan Rennicke #Alternative Health