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Uncovering the Gut-Adipose-Liver Axis: Microbiota Encroachment and Metabolic Dysfunction in MASLD

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Manage episode 496274232 series 3332773
Content provided by ajpgi. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by ajpgi or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

In this episode, coauthors Daria Igudesman and Karen D. Corbin discuss their team’s recently published study, "Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease." This first-in-human study explores how changes in the gut microbiota may contribute to metabolic dysfunction through a gut-adipose-liver axis. The researchers found that colonic expression of insulin and lipid-related genes may link microbial encroachment in the colon with adipose tissue insulin resistance and the development of metabolic dysfunction-associated steatotic liver disease (MASLD). Tune in to learn how these findings offer new insights into the complex interplay between the gut microbiome and metabolic health.

Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease Daria Igudesman, GongXin Yu, Charlene Dauriat, Torfay Roman, Maryam R. Kashi, Elizabeth Blakley, Benoit Chassaing, and Karen D. Corbin

American Journal of Physiology-Gastrointestinal and Liver Physiology 2025 329:1, G201-G214

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49 episodes

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Manage episode 496274232 series 3332773
Content provided by ajpgi. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by ajpgi or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

In this episode, coauthors Daria Igudesman and Karen D. Corbin discuss their team’s recently published study, "Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease." This first-in-human study explores how changes in the gut microbiota may contribute to metabolic dysfunction through a gut-adipose-liver axis. The researchers found that colonic expression of insulin and lipid-related genes may link microbial encroachment in the colon with adipose tissue insulin resistance and the development of metabolic dysfunction-associated steatotic liver disease (MASLD). Tune in to learn how these findings offer new insights into the complex interplay between the gut microbiome and metabolic health.

Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease Daria Igudesman, GongXin Yu, Charlene Dauriat, Torfay Roman, Maryam R. Kashi, Elizabeth Blakley, Benoit Chassaing, and Karen D. Corbin

American Journal of Physiology-Gastrointestinal and Liver Physiology 2025 329:1, G201-G214

  continue reading

49 episodes

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