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Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating Aryl hydrocarbon Receptor-dependent AMPK signaling

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Manage episode 505211844 series 3332773
Content provided by ajpgi. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by ajpgi or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

In this episode, Dr. Aditya Joshi and coauthors discuss their team’s recently published study, “Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating Aryl hydrocarbon Receptor-dependent AMPK signaling." The study showed that absence of AhR in hepatocytes results in exacerbated metabolic dysfunction-associated steatohepatitis (MASH) in mice subjected to Western-style high-fat high-fructose high-cholesterol diet. Moreover, treatment with a tryptophan catabolite, cinnabarinic acid (CA) mitigated hallmarks of MASH in an AhR-dependent manner. In conclusion, the study delineates the significance of hepatic AhR-dependent AMPK signaling in CA-mediated protection against MASH.

Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating Aryl hydrocarbon Receptor-dependent AMPK signaling.

Nikhil Y. Patil, Iulia Rus, Felix Ampadu, Hassan M. Abu Shukair, Sarah Bonvicino, Richard S. Brush, Elena Eaton, Martin-Paul Agbaga, Tae Gyu Oh, Jacob E. Friedman, and Aditya D. Joshi

2025 329:4, G433-G447

  continue reading

50 episodes

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Manage episode 505211844 series 3332773
Content provided by ajpgi. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by ajpgi or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

In this episode, Dr. Aditya Joshi and coauthors discuss their team’s recently published study, “Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating Aryl hydrocarbon Receptor-dependent AMPK signaling." The study showed that absence of AhR in hepatocytes results in exacerbated metabolic dysfunction-associated steatohepatitis (MASH) in mice subjected to Western-style high-fat high-fructose high-cholesterol diet. Moreover, treatment with a tryptophan catabolite, cinnabarinic acid (CA) mitigated hallmarks of MASH in an AhR-dependent manner. In conclusion, the study delineates the significance of hepatic AhR-dependent AMPK signaling in CA-mediated protection against MASH.

Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating Aryl hydrocarbon Receptor-dependent AMPK signaling.

Nikhil Y. Patil, Iulia Rus, Felix Ampadu, Hassan M. Abu Shukair, Sarah Bonvicino, Richard S. Brush, Elena Eaton, Martin-Paul Agbaga, Tae Gyu Oh, Jacob E. Friedman, and Aditya D. Joshi

2025 329:4, G433-G447

  continue reading

50 episodes

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