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In this mind-bending episode, we dive into the fascinating history and modern science of psilocybin, the powerful psychedelic compound found in magic mushrooms. Starting in the sacred mushroom rituals of Mexico, we trace the Western discovery of psilocybin through R. Gordon Wasson and his wife Valentina, whose 1950s journey sparked global curiosity. Learn how Roland Griffiths helped develop the landmark psilocybin protocol at Johns Hopkins, paving the way for groundbreaking clinical trials.

We also explore the cutting-edge brain science led by Robin Carhart-Harris, whose research connects psilocybin with neuroplasticity and healing. Discover the growing body of evidence supporting psilocybin therapy for depression, anxiety, and especially for cancer patients facing end-of-life distress. From ancient rituals to clinical trials, this episode uncovers why psilocybin is no longer just a trip—it's a treatment.

Whether you're curious about the psychedelic renaissance, the role of magic mushrooms in mental health, or the future of psychedelic-assisted therapy, this episode is your launchpad into the mushroom revolution.

Resources:

https://cswr.hds.harvard.edu/news/2024/10/ritual-and-religious-uses-psilocybe-mushrooms-mesoamerica

https://www.ffungi.org/blog/the-earthly-journeys-of-maria-sabina

https://www.carhartharrislab.com/scientific-papers

https://www.nature.com/articles/s44220-024-00331-0

https://www.cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2024-08123&r=1

How to Change Your Mind by Michael Pollan

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