Interviews with mathematics education researchers about recent studies. Hosted by Samuel Otten, University of Missouri. www.mathedpodcast.com Produced by Fibre Studios
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Bottom-Up Midbrain-Subthalamic Control of Feeding
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Manage episode 497251659 series 1457369
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UCLA’s Avishek Adhikari, PhD, presents new research on the role of GABAergic neurons in the brain’s periaqueductal gray (PAG) region. Previously studied for their involvement in fear and defensive behaviors, these neurons were found to promote food-seeking behavior when activated—even in fully fed mice. Using calcium imaging and optogenetics, Adhikari’s team discovered that these neurons are active during food approach but suppressed during eating. The effect is stronger for high-value foods like chocolate or crickets and depends on the mouse’s prior experience with that food. A key finding is that these neurons influence behavior through a specific projection to the zona incerta, a subthalamic region. Rather than signaling hunger, this pathway appears to drive food seeking based on reward value, highlighting a new motivational circuit in the brain. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40444]
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212 episodes
MP4•Episode home
Manage episode 497251659 series 1457369
Content provided by UCTV. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by UCTV or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
UCLA’s Avishek Adhikari, PhD, presents new research on the role of GABAergic neurons in the brain’s periaqueductal gray (PAG) region. Previously studied for their involvement in fear and defensive behaviors, these neurons were found to promote food-seeking behavior when activated—even in fully fed mice. Using calcium imaging and optogenetics, Adhikari’s team discovered that these neurons are active during food approach but suppressed during eating. The effect is stronger for high-value foods like chocolate or crickets and depends on the mouse’s prior experience with that food. A key finding is that these neurons influence behavior through a specific projection to the zona incerta, a subthalamic region. Rather than signaling hunger, this pathway appears to drive food seeking based on reward value, highlighting a new motivational circuit in the brain. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40444]
…
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212 episodes
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