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This case report details a patient with chronic lymphocytic leukemia whose initially misdiagnosed joint pain was ultimately attributed to the rare syndrome of remitting seronegative symmetrical synovitis with pitting edema (RS3PE). The report discusses RS3PE's characteristics, often overlooked due to its rarity and lack of definitive diagnostic criteria, emphasizing the importance of recognizing it in palliative care settings. The paper explores RS3PE's association with malignancy, its clinical presentation mimicking other rheumatological disorders, and its effective treatment with corticosteroids. Furthermore, the study investigates the potential role of vascular endothelial growth factor (VEGF) in RS3PE's pathophysiology. Early diagnosis is crucial for effective pain management and avoiding reliance on ineffective opioid treatments.

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