Whether the topic is popcorn or particle physics, you can count on BrainStuff to explore -- and explain -- the everyday science in the world around us.
…
continue reading
Content provided by Dr. David M. Livingston. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Dr. David M. Livingston or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Similar to The Space Show by Dr. David Livingston
I discuss a variety of topics in both the natural and social sciences, exploring the many fascinating insights that the scientific method yields about the world around us.
…
continue reading
You Are Not So Smart is a show about psychology that celebrates science and self delusion. In each episode, we explore what we've learned so far about reasoning, biases, judgments, and decision-making.
…
continue reading
A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vineeta Agarwala, Julie Yoo, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg Verdine, Fei-Fei Li, and Suchi Saria, as they explore the i ...
…
continue reading
The Science Show gives Australians unique insights into the latest scientific research and debate, from the physics of cricket to prime ministerial biorhythms.
…
continue reading
We take a critter’s eye view to explore how animal behavior parallels humans. Join comedians and science-lovers as we get inside the minds of animals
…
continue reading
The kickass science and technology radio show that delivers an irreverent look at the week in science and technology.
…
continue reading
Scientists Daniel and Kelly cannot stop talking about our amazing, wonderful, weird Universe! Each episode is a fun, easy-to-understand, and in-depth explanation of topics in science, from particles to black holes to moon colonies to ecosystems to parasites and everything else in the Universe!
…
continue reading
When you hear the words Alzheimer's disease, what do you think of? The truth is, the picture most of us have of the disease is incomplete. Alzheimer's disease doesn't start when someone starts to lose their memory. It actually starts years – sometimes decades – earlier. The Rethinking Alzheimer's Disease Podcast is an engaging, narrative-style podcast miniseries for those curious or motivated to learn about Alzheimer’s disease. Perhaps you have a family member with Alzheimer’s disease, or ca ...
…
continue reading
DNA science. Artificial intelligence. Smartphones and 3D printers. Science and technology have transformed the world we live in. But how did we get here? It wasn’t by accident. Well, sometimes it was. It was also the result of hard work, teamwork, and competition. And incredibly surprising moments. Hosted by bestselling author Steven Johnson (“How We Got To Now”), American Innovations uses immersive scenes to tell the stories of the scientists, engineers, and ordinary people behind the great ...
…
continue reading
Player FM - Podcast App
Go offline with the Player FM app!
Go offline with the Player FM app!
))
Mari Anne Snow, CEO, EASCRA Biotech, talks space pharma, making money with space medicine, targeted medical products and more. I promise, a program on this subject like none other !
Manage episode 514149250 series 58876
Content provided by Dr. David M. Livingston. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Dr. David M. Livingston or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Listeners: Watch the video if you can as our guest uses excellent visuals that are more than helpful.
Meeting assets for Space Show with Mari Anne Snow of Eascra, a Nanomedicine company are ready!
The following assets for the meeting - Space Show with Mari Anne Snow of Eascra, a Nanomedicine company are now available.
Our program began with guest Mari Anne Snow, CEO of EASCRA Biotech, focusing ion on the Eascra Biotech's innovative work in nanomedicine, including their space missions and development of Janus-based nanoparticles for medical applications. The discussion concluded with detailed exploration of the company's space-based manufacturing processes, potential profitability, and future plans for clinical trials and product development. Joining us in the Zoom meeting were Dr. A.J. Kothari, John Jossy, and Dr. Phil Swan. All of us spoke feely during the program.
David and Mari discussed the potential of regenerative medicine and its impact on orthopedic surgeries, particularly knee and hip replacements. Mari emphasized that their target customers are not orthopedic surgeons but rather payers and patients, as insurance often covers traditional replacements more readily than alternative treatments. They explored the market opportunities in conditions like osteoarthritis and neuromuscular injuries, as well as kidney diseases, with the goal of offering cost-effective and innovative treatments. David expressed interest in these topics and mentioned his experience with space medicine, noting the lack of awareness among doctors about emerging space medical technologies.
Mari, the Co-founder and CEO of Esker Biotech, discussed her company's innovative work in nanomedicine, focusing on precision therapy delivery solutions for various medical applications. She highlighted their progress, including completing five space missions in 24 months, as evidence of advancements in the commercial space economy. Mari explained that while Eascra is still in early stages and preclinical, they are gathering data to approach the FDA for regulatory approval of space-made products, with the goal of ensuring their space-produced items are equivalent to those made on Earth. The discussion also touched on the company's background, Mari’s experience, and the technical aspects of their work, including the challenges and opportunities in the space and medical fields.
Mari discussed her company’s journey from an academic spin-off of the University of Connecticut to becoming a space medicine company. She explained how the company initially focused on producing nanoparticles on Earth but transitioned to space-based manufacturing after receiving funding and opportunities from NASA's In Space Manufacturing Program. Mari detailed their successful space missions, including working with astronauts like Sunita Williams and Johnny Kim, and described their plans to automate future experiments for increased efficiency.
Mari explained her company's development of Janus-based nanoparticles for medical applications, including mRNA delivery for osteoarthritis treatment and a cell-free scaffold for cartilage regeneration. She described the nanoparticles' unique structure and delivery mechanism, which allows for better cell penetration and bioactivity compared to existing options. Mari also highlighted the advantages of producing these products in space, where microgravity leads to a more uniform and structurally sound scaffold, resulting in improved tissue regeneration and faster healing rates. Note that I did briefly stop her to explain “Janus-based nanoparticles,” a definition and explanation that was definitely helpful.
Mari explained their work on developing medical products, both on Earth and in space, and discussed their progress in gaining FDA approval for their space-created medical product. She mentioned that they have early-stage agreement with the FDA for establishing equivalency between Earth and space samples. David asked about the mechanism for FDA approval of space-created medical products, to which Mari responded that they need to develop this pathway. Mari also addressed David's questions about funding and potential budget cuts, stating that they have stable funding from NASA and an Innovation Grant for a cancer application. She mentioned that they are building relationships with the Department of Defense and SpaceWorks to explore additional funding opportunities and potential applications of their product for troops and long-distance space travel.
Our discussion continued focusing on the company's work with Janus-based nanoparticles and their development in microgravity, which has resulted in structural improvements of over 40% due to the lack of sedimentation and convection. Mari explained that her partner, a biomedical engineer at the University of Connecticut, has developed these technologies with funding from various sources including NIH, NSF, and NASA. The company is exploring partnerships with private space companies and has relationships with Axiom, Vast, and others to determine if parabolic flights or autonomous platforms could be sufficient for their needs. They are also considering lunar applications, though questions remain about the effectiveness of 1.6G on the moon compared to microgravity. Note that our Zoom participants were asking our guest many technical and engineering questions during this discussion though their questions were not specifically mentioned in this AI summary.
Our Space Show team discussed the potential profitability of producing medical materials in space, with Mari explaining that financial models show the venture could be profitable even at small volumes due to premium pricing similar to existing drugs like CAR T cells (for those of you not familiar with this therapy, check it out here: Home - Explore CAR T). Phil offered to share data on launch costs to various orbits, while the group explored questions about future production environments and subsidies. John inquired about clinical indications for human trials, to which Mari explained they would act as a delivery component for licensing partners, with initial in-house products likely focusing on musculoskeletal conditions like osteoarthritis, where there are currently no effective treatments. AJ also offered to share some of his data with Mari.
We discussed manufacturing processes and requirements for space-based medicine production. Mari explained they are currently in proof of concept phase with small batch production, aiming to develop an autonomous production process before scaling up. They confirmed having conversations with Varda and the Explorer company. The production process requires 48 hours in microgravity, making suborbital flights impractical, and the product maintains bioactivity for 6 months at ambient temperature, with plans to test longer-term stability.
As we were moving toward the end of our program, Mari focused on three main questions about her company's space products (listen for them in the program). Mari explained that while they have a 10-year timeline to profitability if costs continue to decrease the timeline might shorten. She said they are already generating revenue from Earth-made products. She highlighted their advantage in delivering various types of nucleic acids and drugs due to their tubular structure, noting plans to test cancer applications with RNA and an FDA-approved drug in early 2026. The conversation also revealed that there are millions in potential healthcare solutions blocked by current delivery mechanisms, with Mari's company potentially addressing this issue through their technology, which has already attracted interest from gene editing companies.
Mari discussed the development and potential of nanotube delivery systems for pharmaceuticals, highlighting their advantages over existing methods like lipid nanoparticles and viral vectors. This would be especially important for gene therapy and editing. She emphasized the simplicity, customizability, and stability of their technology, as well as its potential for tissue penetration and reduced production complexity. The conversation also touched on the commercialization challenges and opportunities in space pharmaceuticals, with Mari noting that space-based testing could accelerate drug development and reduce costs. The group discussed the potential for insurance coverage of advanced medical treatments and the need for validated commercial examples to demonstrate the efficacy of space-based medicine.
Please post your comments/questions for this program on our blog at www.thespaceshow.com. You can also leave comments on our Substack page. I will do my est to follow your comments and make sure our guest is aware of them. Keep in mind it is always up the guest regarding replying to listener blog comments.
Special thanks to our sponsors:Northrup Grumman, American Institute of Aeronautics and Astronautics, Helix Space in Luxembourg, Celestis Memorial Spaceflights, Astrox Corporation, Dr. Haym Benaroya of Rutgers University, The Space Settlement Progress Blog by John Jossy, The Atlantis Project, and Artless Entertainment
Our Toll Free Line for Live Broadcasts: 1-866-687-7223
For real time program participation, email Dr. Space at: [email protected]
The Space Show is a non-profit 501C3 through its parent, One Giant Leap Foundation, Inc. To donate via Pay Pal, use:
To donate with Zelle, use the email address: [email protected].
If you prefer donating with a check, please make the check payable to One Giant Leap Foundation and mail to:
One Giant Leap Foundation, 11035 Lavender Hill Drive Ste. 160-306 Las Vegas, NV 89135
Upcoming Programs:
Broadcast 4422: TBD | Monday 25 Aug 2025 1200PM PT
Guests: Dr. David Livingston
Guest TBD
Live Streaming is at https://www.thespaceshow.com/content/listen-live with the following live streaming sites:
Stream Guys https://player.streamguys.com/thespaceshow/sgplayer3/player.php#
FastServ https://ic2646c302.fastserv.com/stream
Get full access to The Space Show-One Giant Leap Foundation at doctorspace.substack.com/subscribe
1223 episodes
Share
Manage episode 514149250 series 58876
Content provided by Dr. David M. Livingston. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Dr. David M. Livingston or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Listeners: Watch the video if you can as our guest uses excellent visuals that are more than helpful.
Meeting assets for Space Show with Mari Anne Snow of Eascra, a Nanomedicine company are ready!
The following assets for the meeting - Space Show with Mari Anne Snow of Eascra, a Nanomedicine company are now available.
Our program began with guest Mari Anne Snow, CEO of EASCRA Biotech, focusing ion on the Eascra Biotech's innovative work in nanomedicine, including their space missions and development of Janus-based nanoparticles for medical applications. The discussion concluded with detailed exploration of the company's space-based manufacturing processes, potential profitability, and future plans for clinical trials and product development. Joining us in the Zoom meeting were Dr. A.J. Kothari, John Jossy, and Dr. Phil Swan. All of us spoke feely during the program.
David and Mari discussed the potential of regenerative medicine and its impact on orthopedic surgeries, particularly knee and hip replacements. Mari emphasized that their target customers are not orthopedic surgeons but rather payers and patients, as insurance often covers traditional replacements more readily than alternative treatments. They explored the market opportunities in conditions like osteoarthritis and neuromuscular injuries, as well as kidney diseases, with the goal of offering cost-effective and innovative treatments. David expressed interest in these topics and mentioned his experience with space medicine, noting the lack of awareness among doctors about emerging space medical technologies.
Mari, the Co-founder and CEO of Esker Biotech, discussed her company's innovative work in nanomedicine, focusing on precision therapy delivery solutions for various medical applications. She highlighted their progress, including completing five space missions in 24 months, as evidence of advancements in the commercial space economy. Mari explained that while Eascra is still in early stages and preclinical, they are gathering data to approach the FDA for regulatory approval of space-made products, with the goal of ensuring their space-produced items are equivalent to those made on Earth. The discussion also touched on the company's background, Mari’s experience, and the technical aspects of their work, including the challenges and opportunities in the space and medical fields.
Mari discussed her company’s journey from an academic spin-off of the University of Connecticut to becoming a space medicine company. She explained how the company initially focused on producing nanoparticles on Earth but transitioned to space-based manufacturing after receiving funding and opportunities from NASA's In Space Manufacturing Program. Mari detailed their successful space missions, including working with astronauts like Sunita Williams and Johnny Kim, and described their plans to automate future experiments for increased efficiency.
Mari explained her company's development of Janus-based nanoparticles for medical applications, including mRNA delivery for osteoarthritis treatment and a cell-free scaffold for cartilage regeneration. She described the nanoparticles' unique structure and delivery mechanism, which allows for better cell penetration and bioactivity compared to existing options. Mari also highlighted the advantages of producing these products in space, where microgravity leads to a more uniform and structurally sound scaffold, resulting in improved tissue regeneration and faster healing rates. Note that I did briefly stop her to explain “Janus-based nanoparticles,” a definition and explanation that was definitely helpful.
Mari explained their work on developing medical products, both on Earth and in space, and discussed their progress in gaining FDA approval for their space-created medical product. She mentioned that they have early-stage agreement with the FDA for establishing equivalency between Earth and space samples. David asked about the mechanism for FDA approval of space-created medical products, to which Mari responded that they need to develop this pathway. Mari also addressed David's questions about funding and potential budget cuts, stating that they have stable funding from NASA and an Innovation Grant for a cancer application. She mentioned that they are building relationships with the Department of Defense and SpaceWorks to explore additional funding opportunities and potential applications of their product for troops and long-distance space travel.
Our discussion continued focusing on the company's work with Janus-based nanoparticles and their development in microgravity, which has resulted in structural improvements of over 40% due to the lack of sedimentation and convection. Mari explained that her partner, a biomedical engineer at the University of Connecticut, has developed these technologies with funding from various sources including NIH, NSF, and NASA. The company is exploring partnerships with private space companies and has relationships with Axiom, Vast, and others to determine if parabolic flights or autonomous platforms could be sufficient for their needs. They are also considering lunar applications, though questions remain about the effectiveness of 1.6G on the moon compared to microgravity. Note that our Zoom participants were asking our guest many technical and engineering questions during this discussion though their questions were not specifically mentioned in this AI summary.
Our Space Show team discussed the potential profitability of producing medical materials in space, with Mari explaining that financial models show the venture could be profitable even at small volumes due to premium pricing similar to existing drugs like CAR T cells (for those of you not familiar with this therapy, check it out here: Home - Explore CAR T). Phil offered to share data on launch costs to various orbits, while the group explored questions about future production environments and subsidies. John inquired about clinical indications for human trials, to which Mari explained they would act as a delivery component for licensing partners, with initial in-house products likely focusing on musculoskeletal conditions like osteoarthritis, where there are currently no effective treatments. AJ also offered to share some of his data with Mari.
We discussed manufacturing processes and requirements for space-based medicine production. Mari explained they are currently in proof of concept phase with small batch production, aiming to develop an autonomous production process before scaling up. They confirmed having conversations with Varda and the Explorer company. The production process requires 48 hours in microgravity, making suborbital flights impractical, and the product maintains bioactivity for 6 months at ambient temperature, with plans to test longer-term stability.
As we were moving toward the end of our program, Mari focused on three main questions about her company's space products (listen for them in the program). Mari explained that while they have a 10-year timeline to profitability if costs continue to decrease the timeline might shorten. She said they are already generating revenue from Earth-made products. She highlighted their advantage in delivering various types of nucleic acids and drugs due to their tubular structure, noting plans to test cancer applications with RNA and an FDA-approved drug in early 2026. The conversation also revealed that there are millions in potential healthcare solutions blocked by current delivery mechanisms, with Mari's company potentially addressing this issue through their technology, which has already attracted interest from gene editing companies.
Mari discussed the development and potential of nanotube delivery systems for pharmaceuticals, highlighting their advantages over existing methods like lipid nanoparticles and viral vectors. This would be especially important for gene therapy and editing. She emphasized the simplicity, customizability, and stability of their technology, as well as its potential for tissue penetration and reduced production complexity. The conversation also touched on the commercialization challenges and opportunities in space pharmaceuticals, with Mari noting that space-based testing could accelerate drug development and reduce costs. The group discussed the potential for insurance coverage of advanced medical treatments and the need for validated commercial examples to demonstrate the efficacy of space-based medicine.
Please post your comments/questions for this program on our blog at www.thespaceshow.com. You can also leave comments on our Substack page. I will do my est to follow your comments and make sure our guest is aware of them. Keep in mind it is always up the guest regarding replying to listener blog comments.
Special thanks to our sponsors:Northrup Grumman, American Institute of Aeronautics and Astronautics, Helix Space in Luxembourg, Celestis Memorial Spaceflights, Astrox Corporation, Dr. Haym Benaroya of Rutgers University, The Space Settlement Progress Blog by John Jossy, The Atlantis Project, and Artless Entertainment
Our Toll Free Line for Live Broadcasts: 1-866-687-7223
For real time program participation, email Dr. Space at: [email protected]
The Space Show is a non-profit 501C3 through its parent, One Giant Leap Foundation, Inc. To donate via Pay Pal, use:
To donate with Zelle, use the email address: [email protected].
If you prefer donating with a check, please make the check payable to One Giant Leap Foundation and mail to:
One Giant Leap Foundation, 11035 Lavender Hill Drive Ste. 160-306 Las Vegas, NV 89135
Upcoming Programs:
Broadcast 4422: TBD | Monday 25 Aug 2025 1200PM PT
Guests: Dr. David Livingston
Guest TBD
Live Streaming is at https://www.thespaceshow.com/content/listen-live with the following live streaming sites:
Stream Guys https://player.streamguys.com/thespaceshow/sgplayer3/player.php#
FastServ https://ic2646c302.fastserv.com/stream
Get full access to The Space Show-One Giant Leap Foundation at doctorspace.substack.com/subscribe
1223 episodes
All episodes
×
Welcome to Player FM!
Player FM is scanning the web for high-quality podcasts for you to enjoy right now. It's the best podcast app and works on Android, iPhone, and the web. Signup to sync subscriptions across devices.
Similar to The Space Show by Dr. David Livingston
Whether the topic is popcorn or particle physics, you can count on BrainStuff to explore -- and explain -- the everyday science in the world around us.
…
continue reading
I discuss a variety of topics in both the natural and social sciences, exploring the many fascinating insights that the scientific method yields about the world around us.
…
continue reading
You Are Not So Smart is a show about psychology that celebrates science and self delusion. In each episode, we explore what we've learned so far about reasoning, biases, judgments, and decision-making.
…
continue reading
A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vineeta Agarwala, Julie Yoo, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg Verdine, Fei-Fei Li, and Suchi Saria, as they explore the i ...
…
continue reading
The Science Show gives Australians unique insights into the latest scientific research and debate, from the physics of cricket to prime ministerial biorhythms.
…
continue reading
We take a critter’s eye view to explore how animal behavior parallels humans. Join comedians and science-lovers as we get inside the minds of animals
…
continue reading
The kickass science and technology radio show that delivers an irreverent look at the week in science and technology.
…
continue reading
Scientists Daniel and Kelly cannot stop talking about our amazing, wonderful, weird Universe! Each episode is a fun, easy-to-understand, and in-depth explanation of topics in science, from particles to black holes to moon colonies to ecosystems to parasites and everything else in the Universe!
…
continue reading
When you hear the words Alzheimer's disease, what do you think of? The truth is, the picture most of us have of the disease is incomplete. Alzheimer's disease doesn't start when someone starts to lose their memory. It actually starts years – sometimes decades – earlier. The Rethinking Alzheimer's Disease Podcast is an engaging, narrative-style podcast miniseries for those curious or motivated to learn about Alzheimer’s disease. Perhaps you have a family member with Alzheimer’s disease, or ca ...
…
continue reading
DNA science. Artificial intelligence. Smartphones and 3D printers. Science and technology have transformed the world we live in. But how did we get here? It wasn’t by accident. Well, sometimes it was. It was also the result of hard work, teamwork, and competition. And incredibly surprising moments. Hosted by bestselling author Steven Johnson (“How We Got To Now”), American Innovations uses immersive scenes to tell the stories of the scientists, engineers, and ordinary people behind the great ...
…
continue reading
Player FM - Podcast App
Go offline with the Player FM app!
Go offline with the Player FM app!
