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Dr. Space, host of The Space Show, recently hosted a compelling conversation with Ben Roberts, founder and CEO of Skyworker Work Group Finance and Advisory Surfaces LLC. The discussion centered on financing space business entrepreneurs developing health and material products in microgravity. They explored how the unique conditions of space, specifically the absence of gravity—can be leveraged to manufacture advanced materials and medical goods. These include protein crystals for medicines, engineered nanoparticles, 3D-printed cardiac tissue, and accelerated aging models for studying diseases such as Parkinson’s and Alzheimer’s.

Although the microgravity economy remains in its early stages, with no companies yet achieving significant commercial profitability, several ventures are nearing viability. Experts believe these companies could access substantial markets within the next 3–5 years, once regulatory hurdles are cleared.

Our guest Ben outlined the foundations of in-space manufacturing. He explained how microgravity eliminates forces like sedimentation and convection, enabling the creation of next-generation materials and technologies that may no longer be feasible to produce on Earth. While the concept has been explored for decades, real progress has emerged only in the past 5–6 years, with more defined use cases nearing commercialization.

Key applications discussed include:

* High-quality protein crystals for drug development;

* Advanced nanoparticles;

* 3D-printed cardiac tissue;

* Accelerated aging studies for neurological diseases.

Ben likened the microgravity economy to the startup ecosystem 15 years ago—rich in innovation and investor interest, but still pre-revenue. He pointed out that many space-based life science companies are close to proving commercial viability. These businesses could tap into eight- or nine-figure markets once they secure regulatory approvals.

As an example, he cited LambdaVision,a company developing artificial retinas. Initially funded through federal R&D grants, the company now requires relatively modest monthly investments ($25,000–$50,000) to complete clinical trials.

Ben discussed the broader political and funding environment. While microgravity research is not currently a federal priority, bipartisan coalitions are emerging in Congress. He noted that most ventures are focused on low Earth orbit (LEO), where zero gravity can be achieved without needing to go to cislunar space. The sector remains early in the "hype curve," but Ben was optimistic that commercial breakthroughs—such as personalized cancer treatments—could arrive within 3–5 years, potentially at a fraction of traditional pharmaceutical development costs.

A listener email from Jane raised the issue of limited awareness among doctors regarding space-based medical solutions, like printing replacement menisci in orbit for people with damaged knees. She also suggested that doctors dismiss such ideas or products thus patients remain in the dark about the progress unless they start internet searches themselves. Ben acknowledged this gap but noted that companies such as Redwire are actively collaborating with medical institutions. Responding to another listener, Jerry, he addressed the uncertain future of the ISS and the coming role of private space stations. Ben suggested that some manufacturing processes may not require constant human presence and could benefit from uncrewed or short-duration orbital platforms.

Our guest highlighted growing international interest, including from China, in space manufacturing. He noted that many ventures in this sector can operate with relatively modest capital (eight figures), making global partnerships feasible—especially for life sciences applications. Although many U.S. companies are focused on other space segments, the microgravity manufacturing niche is largely populated by small U.S.-based firms. On space tourism, Ben explained that the main obstacle is not technology but the business model. Even with costs dropping from $50 million to $10 million per seat, space tourism remains out of reach for most consumers.

When I asked our guest how to pitch space ventures such as those we have been talking about to investors, Ben suggested presenting space as a nascent but high-potential industry—akin to early-stage AI or social media. He emphasized the need for honesty about risks while pointing out the sector’s long-term upside. He noted that space ventures can yield high impact, citing efforts to cure blindness or treat degenerative diseases, but they require years of development and significant investment. Once established, however, these companies may enjoy insulation from competition with huge global markets.

Ben touched on the difficulties of investing in space settlement, suggesting that lunar habitats are not yet commercially viable due to supply chain and infrastructure constraints. He also discussed the high costs and insurance coverage implications of new space-based medical technologies, such as artificial retinas designed to restore vision. He mentioned a cancer drug company that improved its product through microgravity R&D and subsequently saw notable financial returns. Ben noted insurance challenges. For example, how would a commercial company insure its hardware and infrastructure in LEO or on the lunar surface? How would one value it?

He addressed legal concerns such as property rights in space, particularly in the context of commercial space stations. Questions remain, especially regarding bankruptcy and asset ownership in orbit, but regulators still have time to address these challenges. I noted growing interest from major investment banks, citing Firefly Aerospace’s IPO and its support from institutions in the U.S., U.K., and Germany as evidence that traditional finance is beginning to take space ventures seriously. Our guest had much to say on this matter, the larger, global and powerful banking and investment houses, especially when compared to the angles helping the entrepreneurs raise necessary funding.

I asked our guest, Ben Roberts, in his conclusion to share insights into investing in space-related startups. He emphasized that these are high-risk, venture-style deals typically available only to accredited investors. He advised against using retirement or college savings for such investments, recommending instead a diversified portfolio approach. Ben offered to connect interested investors with opportunities and recommended sources for updates in these opportunities and markets. Before ending, I asked about investment or entrepreneurial interest in future applications of space technology in veterinary medicine. I was a bit surprised that he said no given how large the vet and pet markets have become, especially in the US and other countries. If anybody out there is listening, perhaps there might be ground flow opportunities looming for those that know what is happening in terrestrial pet and vet markets.

Listeners interested in learning more or exploring investment opportunities can contact Ben at [email protected].

This summary has been posted at www.thespaceshow.com for this program on August 8, 2025 plus our Substack page, doctorspac.substack.com.

Special thanks to our sponsors:Northrup Grumman, American Institute of Aeronautics and Astronautics, Helix Space in Luxembourg, Celestis Memorial Spaceflights, Astrox Corporation, Dr. Haym Benaroya of Rutgers University, The Space Settlement Progress Blog by John Jossy, The Atlantis Project, and Artless Entertainment

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