Hosts Paul and Gino sit down with scientist and independent researcher Nuriye Sinem Berthier. With a rich background in chemistry, pharmacology, genetics, and biochemistry, and personal experience as a parent navigating autism, Sinem offers a unique lens on child development, neurodiversity, and the microbiome.

She introduces her Autism Cascade Hypothesis, highlighting how early-life environmental factors—including birth method, feeding choices, and gut health—may influence neurodevelopment. Sinem also discusses the critical role of probiotics, fermented foods, and cultural perspectives in supporting healthy development.

This conversation blends cutting-edge science with lived experience, empowering families with new insights and sparking dialogue on how culture shapes our understanding of neurodiversity.

Connect With Nuriye Sinem Berthier

LinkedIn: http://www.linkedin.com/in/sinem-berthier

Orcid Account: https://orcid.org/0009-0002-5840-7957

Journal Articles:

1. Proposing the Autism Cascade Hypothesis: A Novel Mechanistic Framework Linking Dietary Peptides, Neuroimmune Activation, and Developmental Timing. https://zenodo.org/records/17007271

2. Cascading Pathways in Autism: A New Clinical Lens on Early Pediatric Intervention. https://zenodo.org/records/17019400

Connect With Us

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Episode Chapters

• 00:00 – Podcast Introduction
• 02:05 – Meet Sinem Berthier
• 03:13 – Shifting Paths: From Pharma to Independent Research
• 05:07 – Understanding the Autism Cascade Hypothesis
• 09:17 – Practical Steps for Families
• 10:21 – Common Misconceptions About Autism
• 11:05 – Bridging Science & Everyday Families
• 11:36 – Creating Le Fermentis
• 13:12 – Community & Cultural Awareness
• 14:20 – Empowering Parents
• 15:16 – Looking Ahead in Research
• 16:02 – Legacy & Impact
• 16:38 – Conclusion and Reflections

Disclaimer:

The content provided in this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have heard on this podcast.