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Ep. 74: “Dengue Pathogenesis” Featuring Dr. Neelika Malavige

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Manage episode 406143724 series 2895470
Content provided by The Immunology Podcast. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by The Immunology Podcast or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

Guest:

Dr. Neelika Malavige is the Head of Dengue Global Program and Scientific Affairs at the Drugs for Neglected Diseases Initiative and a Professor in the Department of Immunology and Molecular Medicine at the University of Sri Jayewardenepura. Her research focuses on dengue: its pathogenesis, vascular leak, immune correlates of protection, and biomarkers. She talks about the disease burden of dengue and her investigations into risk factors for severe disease. She also discusses her research on COVID-19 vaccines and the role of the microbiome in colon cancer, as well as how she’s working to grow research capabilities in Sri Lanka.

Featured Products and Resources:

The Immunology Round Up

SOX17 in Colorectal Cancer – Scientists used AKP organoids to demonstrate that SOX17 orchestrates immune evasion in the early steps of colon cancer.

Tregs in Tumor Immunity – Lactate uptake by Treg cells contributes to the efficacy of CTLA-4 blockade.

Astrocytes in Autoimmunity – Researchers identified astrocyte-derived heparin-binding EGF-like growth factor as a potential therapeutic target in multiple sclerosis.

αβ T Cell Development – By studying patients with pre-TCRα deficiency, scientists found that pre-TCRα may not be absolutely required for αβ T cell development in humans.

Image courtesy of Dr. Neelika Malavige

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130 episodes

Artwork
iconShare
 
Manage episode 406143724 series 2895470
Content provided by The Immunology Podcast. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by The Immunology Podcast or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

Guest:

Dr. Neelika Malavige is the Head of Dengue Global Program and Scientific Affairs at the Drugs for Neglected Diseases Initiative and a Professor in the Department of Immunology and Molecular Medicine at the University of Sri Jayewardenepura. Her research focuses on dengue: its pathogenesis, vascular leak, immune correlates of protection, and biomarkers. She talks about the disease burden of dengue and her investigations into risk factors for severe disease. She also discusses her research on COVID-19 vaccines and the role of the microbiome in colon cancer, as well as how she’s working to grow research capabilities in Sri Lanka.

Featured Products and Resources:

The Immunology Round Up

SOX17 in Colorectal Cancer – Scientists used AKP organoids to demonstrate that SOX17 orchestrates immune evasion in the early steps of colon cancer.

Tregs in Tumor Immunity – Lactate uptake by Treg cells contributes to the efficacy of CTLA-4 blockade.

Astrocytes in Autoimmunity – Researchers identified astrocyte-derived heparin-binding EGF-like growth factor as a potential therapeutic target in multiple sclerosis.

αβ T Cell Development – By studying patients with pre-TCRα deficiency, scientists found that pre-TCRα may not be absolutely required for αβ T cell development in humans.

Image courtesy of Dr. Neelika Malavige

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130 episodes

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