A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
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continue reading
Content provided by Stanford Engineering & Russ Altman and Stanford Engineering. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Stanford Engineering & Russ Altman and Stanford Engineering or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
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The future of bone health
Manage episode 504655057 series 2712286
Content provided by Stanford Engineering & Russ Altman and Stanford Engineering. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Stanford Engineering & Russ Altman and Stanford Engineering or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Endocrinologist Joy Wu says that osteoporosis can affect more than half of women and a quarter of men over 50 – often without symptoms until a fracture changes everything, leading to a loss of mobility and independence. Wu explains why bones weaken with age and how to strengthen them through exercise and smart medicine. Her lab is exploring innovative drugs and turning skin cells into new bone-forming osteoblasts. We’re delving into the great mystery of building new bone and making old bones stronger, Wu tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.
Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to [email protected].
Episode Reference Links:
- Stanford Profile: Joy Wu
Connect With Us:
- Episode Transcripts >>> The Future of Everything Website
- Connect with Russ >>> Threads / Bluesky / Mastodon
- Connect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / Facebook
Chapters:
(00:00:00) Introduction
Russ Altman introduces guest Joy Wu, a professor of endocrinology at Stanford University.
(00:03:06) Path into Bone Research
Joy shares her path from endocrinology training to studying bone biology.
(00:04:10) Calcium and Vitamin D in Bone Health
How these nutrients build strong bones and prevent fractures.
(00:05:13) Why Bones Heal Themselves
Why bones can regenerate so effectively compared to other tissues.
(00:06:26) Can We Feel Our Bones?
The mystery of weather-related aches at old fracture sites.
(00:07:23) Understanding Osteoporosis
The prevalence of osteoporosis in the elderly, especially in women.
(00:08:34) Diagnosing Osteoporosis
Why osteoporosis often goes undetected until fractures appear.
(00:09:36) Risk Factors Beyond Aging
The risk factors outside of aging that can lead to osteoporosis.
(00:10:48) Steroids, Exercise, and Bone Health
The impact of systemic steroids and exercise on bone health.
(00:12:40) Height Loss and Spine Fractures
How shrinking height in older adults can signal vertebral fractures.
(00:14:46) Cancer and Bone Health
How cancers spread to bone and how therapies affect bone health.
(00:17:09) Medications for Osteoporosis
The complexities of using certain medications in cancer patients with bone loss.
(00:20:10) Hormones and Bone Growth
Using SERMs to protect bone while reducing breast cancer risk.
(00:21:45) Stem Cells and Building Bone
Research on reprogramming skin cells into bone-forming osteoblasts.
(00:23:31) Why Treatments Plateau
Why bone-building drugs stop working after two years.
(00:24:49) Challenges in Bone Regeneration
The potential of Wnt signalling and stem cells in lasting bone regeneration.
(00:28:09) Validating Osteoblasts in the Lab
Testing whether reprogrammed cells behave like natural osteoblasts.
(00:29:11) Future Outlook for Bone Biology
The limits of bone cell replication and what it means for future therapies.
(00:30:10) Advice for Strong Bones
Practical do’s and don’ts for optimizing bone health.
(00:32:41) Conclusion
Connect With Us:
Episode Transcripts >>> The Future of Everything Website
Connect with Russ >>> Threads / Bluesky / Mastodon
Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
345 episodes
Share
Manage episode 504655057 series 2712286
Content provided by Stanford Engineering & Russ Altman and Stanford Engineering. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Stanford Engineering & Russ Altman and Stanford Engineering or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.
Endocrinologist Joy Wu says that osteoporosis can affect more than half of women and a quarter of men over 50 – often without symptoms until a fracture changes everything, leading to a loss of mobility and independence. Wu explains why bones weaken with age and how to strengthen them through exercise and smart medicine. Her lab is exploring innovative drugs and turning skin cells into new bone-forming osteoblasts. We’re delving into the great mystery of building new bone and making old bones stronger, Wu tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.
Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to [email protected].
Episode Reference Links:
- Stanford Profile: Joy Wu
Connect With Us:
- Episode Transcripts >>> The Future of Everything Website
- Connect with Russ >>> Threads / Bluesky / Mastodon
- Connect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / Facebook
Chapters:
(00:00:00) Introduction
Russ Altman introduces guest Joy Wu, a professor of endocrinology at Stanford University.
(00:03:06) Path into Bone Research
Joy shares her path from endocrinology training to studying bone biology.
(00:04:10) Calcium and Vitamin D in Bone Health
How these nutrients build strong bones and prevent fractures.
(00:05:13) Why Bones Heal Themselves
Why bones can regenerate so effectively compared to other tissues.
(00:06:26) Can We Feel Our Bones?
The mystery of weather-related aches at old fracture sites.
(00:07:23) Understanding Osteoporosis
The prevalence of osteoporosis in the elderly, especially in women.
(00:08:34) Diagnosing Osteoporosis
Why osteoporosis often goes undetected until fractures appear.
(00:09:36) Risk Factors Beyond Aging
The risk factors outside of aging that can lead to osteoporosis.
(00:10:48) Steroids, Exercise, and Bone Health
The impact of systemic steroids and exercise on bone health.
(00:12:40) Height Loss and Spine Fractures
How shrinking height in older adults can signal vertebral fractures.
(00:14:46) Cancer and Bone Health
How cancers spread to bone and how therapies affect bone health.
(00:17:09) Medications for Osteoporosis
The complexities of using certain medications in cancer patients with bone loss.
(00:20:10) Hormones and Bone Growth
Using SERMs to protect bone while reducing breast cancer risk.
(00:21:45) Stem Cells and Building Bone
Research on reprogramming skin cells into bone-forming osteoblasts.
(00:23:31) Why Treatments Plateau
Why bone-building drugs stop working after two years.
(00:24:49) Challenges in Bone Regeneration
The potential of Wnt signalling and stem cells in lasting bone regeneration.
(00:28:09) Validating Osteoblasts in the Lab
Testing whether reprogrammed cells behave like natural osteoblasts.
(00:29:11) Future Outlook for Bone Biology
The limits of bone cell replication and what it means for future therapies.
(00:30:10) Advice for Strong Bones
Practical do’s and don’ts for optimizing bone health.
(00:32:41) Conclusion
Connect With Us:
Episode Transcripts >>> The Future of Everything Website
Connect with Russ >>> Threads / Bluesky / Mastodon
Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
345 episodes
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Similar to The Future of Everything
A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
…
continue reading
When you hear the words Alzheimer's disease, what do you think of? The truth is, the picture most of us have of the disease is incomplete. Alzheimer's disease doesn't start when someone starts to lose their memory. It actually starts years – sometimes decades – earlier. The Rethinking Alzheimer's Disease Podcast is an engaging, narrative-style podcast miniseries for those curious or motivated to learn about Alzheimer’s disease. Perhaps you have a family member with Alzheimer’s disease, or ca ...
…
continue reading
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
continue reading
Whether the topic is popcorn or particle physics, you can count on BrainStuff to explore -- and explain -- the everyday science in the world around us.
…
continue reading
I discuss a variety of topics in both the natural and social sciences, exploring the many fascinating insights that the scientific method yields about the world around us.
…
continue reading
Emergency Medicine Cases – Where the Experts Keep You in the Know. For show notes, quizzes, videos and more learning tools please visit emergencymedicinecases.com
…
continue reading
Whether we wear a lab coat or haven't seen a test tube since grade school, science is shaping all of our lives. And that means we all have science stories to tell. Every year, we host dozens of live shows all over the country, featuring all kinds of storytellers - researchers, doctors, and engineers of course, but also patients, poets, comedians, cops, and more. Some of our stories are heartbreaking, others are hilarious, but they're all true and all very personal. Welcome to The Story Collider!
…
continue reading
The Science Show gives Australians unique insights into the latest scientific research and debate, from the physics of cricket to prime ministerial biorhythms.
…
continue reading
The kickass science and technology radio show that delivers an irreverent look at the week in science and technology.
…
continue reading
Best Business Podcast (Gold), British Podcast Awards 2023 How do you build a fully electric motorcycle with no compromises on performance? How can we truly experience what the virtual world feels like? What does it take to design the first commercially available flying car? And how do you build a lightsaber? These are some of the questions this podcast answers as we share the moments where digital transforms physical, and meet the brilliant minds behind some of the most innovative products a ...
…
continue reading
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