The provided text explores the complex relationship between endometriosis and autoimmune diseases, highlighting that endometriosis is increasingly understood as a systemic, chronic inflammatory condition rather than solely a localized pelvic disorder. It thoroughly reviews epidemiological data, demonstrating a significant and consistent increased risk of various autoimmune conditions in individuals with endometriosis. The sources further illuminate the shared biological underpinnings, detailing how both conditions involve immune system dysregulation, common inflammatory pathways, and overlapping genetic susceptibilities. While acknowledging the academic debate over whether endometriosis is formally an autoimmune disease, the text emphasizes the clinical implications of this comorbidity, including diagnostic challenges due to symptom overlap and the need for multidisciplinary care and targeted immunotherapy research.