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Biotechnological Approaches in Regenerative Medicine

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Manage episode 499589085 series 3673715
Content provided by Andre Paquette. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Andre Paquette or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

The provided text offers a comprehensive overview of regenerative medicine, an evolving interdisciplinary field focused on restoring damaged biological function. It explains how this paradigm shift in therapeutic strategy leverages three core biotechnological pillars: cell-based therapies, utilizing various stem cell types like embryonic, adult, and induced pluripotent stem cells; gene-based interventions, which employ viral and non-viral vectors to introduce, delete, or modify genetic material, including advanced CRISPR/Cas9 genome editing; and tissue engineering, which constructs biological matrices using biomaterial scaffolds, hydrogels, and decellularization techniques. The document further details advanced biofabrication platforms such as 3D bioprinting and organoid technology, highlighting their applications in treating major diseases like cardiovascular, neurodegenerative, and musculoskeletal conditions. Finally, it addresses the translational challenges from research to clinical availability, including complex manufacturing, stringent quality control, global regulatory frameworks like the FDA's RMAT designation, and the significant ethical, legal, and social implications of these transformative technologies.

Research done with the help of artificial intelligence, and presented by two AI-generated hosts.

  continue reading

359 episodes

Artwork
iconShare
 
Manage episode 499589085 series 3673715
Content provided by Andre Paquette. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Andre Paquette or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

The provided text offers a comprehensive overview of regenerative medicine, an evolving interdisciplinary field focused on restoring damaged biological function. It explains how this paradigm shift in therapeutic strategy leverages three core biotechnological pillars: cell-based therapies, utilizing various stem cell types like embryonic, adult, and induced pluripotent stem cells; gene-based interventions, which employ viral and non-viral vectors to introduce, delete, or modify genetic material, including advanced CRISPR/Cas9 genome editing; and tissue engineering, which constructs biological matrices using biomaterial scaffolds, hydrogels, and decellularization techniques. The document further details advanced biofabrication platforms such as 3D bioprinting and organoid technology, highlighting their applications in treating major diseases like cardiovascular, neurodegenerative, and musculoskeletal conditions. Finally, it addresses the translational challenges from research to clinical availability, including complex manufacturing, stringent quality control, global regulatory frameworks like the FDA's RMAT designation, and the significant ethical, legal, and social implications of these transformative technologies.

Research done with the help of artificial intelligence, and presented by two AI-generated hosts.

  continue reading

359 episodes

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