Season 1: The Science of Aging | Episode 9: Immunosenescence, Inflammaging, Microbiome, & CHIP

In this episode of "Deep Dive," we delve into the complex changes in our immune system as we age. Using the relatable example of Alex, a 68-year-old who faces more frequent and severe illnesses, we explore the biology behind these changes and their profound implications on health. We discuss immunosenescence—the gradual decline of the immune system—and inflammaging, the chronic low-level inflammation that often accompanies aging.

Listeners will gain insights into critical concepts such as immunosenescence, inflammation, the role of the aging microbiome, and clonal hematopoiesis of indeterminate potential (CHIP). These topics are explored in a manner that balances depth and engagement, aiming to simplify complex scientific processes.

From explaining the intricate workings of both the innate and adaptive immune systems to discussing real-world implications like vaccine effectiveness and increased vulnerability to diseases, this episode is packed with information. We also highlight potential interventions and lifestyle strategies to maintain immune function as we age, such as nutrition, activity, and innovative therapies on the horizon.

Join us as we demystify how aging affects our immune defenses and discover practical tips to support resilience in the later stages of life. This episode promises a thorough understanding of why our immune system ages and how we can protect our health through informed actions.