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From Jellyfish to Wound Healing with Dr Andrew Mearns-Spragg

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Manage episode 513270101 series 3556156
Content provided by Mark Davison. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Mark Davison or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

What if the solution to chronic wound healing has been floating in our oceans for 600 million years?

Jellyfish collagen isn't just different from the cow and pig-derived materials used in medicine today. It's actually better at healing human tissue.

I sit down with Dr Andrew Mearns-Spragg, Founder and Chief Scientific Officer at Jellagen, who's proving this remarkable claim with hard data. His research shows jellyfish collagen outperforms traditional materials in vocal fold repair, triggers faster transitions from inflammation to healing, and creates longer-lasting tissue structure. The secret lies in what Andrew calls "collagen type zero," an evolutionarily ancient form that our bodies recognise differently, prompting superior healing responses without the prolonged inflammatory reactions seen with mammalian sources.

Beyond the compelling science, Andrew reveals how he built the world's first ISO-certified medical device manufacturing plant for jellyfish collagen from scratch. We explore the practical realities of sustainable harvesting (achieving near-zero bycatch), navigating FDA regulations for an entirely novel biomaterial, and convincing investors to back marine biotechnology.

This venture extends beyond the laboratory. By harvesting jellyfish blooms caused by overfishing, Jellagen addresses an ecological problem while creating advanced wound care solutions and providing alternative income for local fishing communities struggling with depleted fish stocks.

"The jellyfish collagen transition to healing was much quicker and longer lasting." - Dr Andrew Mearns-Spragg

You'll Hear About

  • Why jellyfish collagen outperforms mammalian collagen in tissue healing
  • The challenges of building ISO-certified jellyfish manufacturing
  • How ancient collagen triggers better immune responses
  • Sustainable harvesting methods with near-zero bycatch
  • Translating marine biology research into medical devices
  • The cost of chronic wound management in healthcare
  • Navigating the FDA regulatory pathway for novel biomaterials
  • Supporting local fishing communities through jellyfish harvesting
  • From angel investment to medical device commercialization
  • Platform opportunities beyond wound healing applications

Connect with Dr Andrew Mearns-Spragg

LinkedIn - https://www.linkedin.com/in/andrew-m-006bb41/

Website - https://jellagen.co.uk/

Connect with me:

LinkedIn: https://www.linkedin.com/in/markdavison100/

If you need any lab equipment:

Grant Instruments: https://www.grantinstruments.com/

Grant Instruments on LinkedIn: https://www.linkedin.com/company/grant-instruments-cambridge-ltd/

  continue reading

Chapters

1. From Jellyfish to Wound Healing with Dr Andrew Mearns-Spragg (00:00:00)

2. What is Jellagen and jellyfish collagen (00:01:10)

3. Ocean biodiversity at the microscale (00:03:19)

4. Why collagen matters in medicine (00:04:32)

5. The problem with cartilage healing (00:07:08)

6. Discovering collagen type zero (00:09:10)

7. Jellyfish collagen outperforms mammalian sources (00:10:40)

8. Vocal fold repair study results (00:12:28)

9. Sourcing jellyfish sustainably (00:17:15)

10. Building an ISO-certified manufacturing facility (00:20:56)

11. Near-zero bycatch harvesting methods (00:22:23)

12. Purification and medical-grade processing (00:23:42)

13. Marine virus risk and contamination (00:25:18)

14. Choosing medical devices over supply business (00:27:14)

15. Building investor confidence in biotech (00:29:52)

16. Path to regulatory approval (00:33:05)

17. Cosmetic applications and market scale (00:33:57)

18. Future platform opportunities (00:35:05)

19. Supporting local fishing communities (00:36:31)

26 episodes

Artwork
iconShare
 
Manage episode 513270101 series 3556156
Content provided by Mark Davison. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Mark Davison or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

What if the solution to chronic wound healing has been floating in our oceans for 600 million years?

Jellyfish collagen isn't just different from the cow and pig-derived materials used in medicine today. It's actually better at healing human tissue.

I sit down with Dr Andrew Mearns-Spragg, Founder and Chief Scientific Officer at Jellagen, who's proving this remarkable claim with hard data. His research shows jellyfish collagen outperforms traditional materials in vocal fold repair, triggers faster transitions from inflammation to healing, and creates longer-lasting tissue structure. The secret lies in what Andrew calls "collagen type zero," an evolutionarily ancient form that our bodies recognise differently, prompting superior healing responses without the prolonged inflammatory reactions seen with mammalian sources.

Beyond the compelling science, Andrew reveals how he built the world's first ISO-certified medical device manufacturing plant for jellyfish collagen from scratch. We explore the practical realities of sustainable harvesting (achieving near-zero bycatch), navigating FDA regulations for an entirely novel biomaterial, and convincing investors to back marine biotechnology.

This venture extends beyond the laboratory. By harvesting jellyfish blooms caused by overfishing, Jellagen addresses an ecological problem while creating advanced wound care solutions and providing alternative income for local fishing communities struggling with depleted fish stocks.

"The jellyfish collagen transition to healing was much quicker and longer lasting." - Dr Andrew Mearns-Spragg

You'll Hear About

  • Why jellyfish collagen outperforms mammalian collagen in tissue healing
  • The challenges of building ISO-certified jellyfish manufacturing
  • How ancient collagen triggers better immune responses
  • Sustainable harvesting methods with near-zero bycatch
  • Translating marine biology research into medical devices
  • The cost of chronic wound management in healthcare
  • Navigating the FDA regulatory pathway for novel biomaterials
  • Supporting local fishing communities through jellyfish harvesting
  • From angel investment to medical device commercialization
  • Platform opportunities beyond wound healing applications

Connect with Dr Andrew Mearns-Spragg

LinkedIn - https://www.linkedin.com/in/andrew-m-006bb41/

Website - https://jellagen.co.uk/

Connect with me:

LinkedIn: https://www.linkedin.com/in/markdavison100/

If you need any lab equipment:

Grant Instruments: https://www.grantinstruments.com/

Grant Instruments on LinkedIn: https://www.linkedin.com/company/grant-instruments-cambridge-ltd/

  continue reading

Chapters

1. From Jellyfish to Wound Healing with Dr Andrew Mearns-Spragg (00:00:00)

2. What is Jellagen and jellyfish collagen (00:01:10)

3. Ocean biodiversity at the microscale (00:03:19)

4. Why collagen matters in medicine (00:04:32)

5. The problem with cartilage healing (00:07:08)

6. Discovering collagen type zero (00:09:10)

7. Jellyfish collagen outperforms mammalian sources (00:10:40)

8. Vocal fold repair study results (00:12:28)

9. Sourcing jellyfish sustainably (00:17:15)

10. Building an ISO-certified manufacturing facility (00:20:56)

11. Near-zero bycatch harvesting methods (00:22:23)

12. Purification and medical-grade processing (00:23:42)

13. Marine virus risk and contamination (00:25:18)

14. Choosing medical devices over supply business (00:27:14)

15. Building investor confidence in biotech (00:29:52)

16. Path to regulatory approval (00:33:05)

17. Cosmetic applications and market scale (00:33:57)

18. Future platform opportunities (00:35:05)

19. Supporting local fishing communities (00:36:31)

26 episodes

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