Episode 208: Nitric Oxide - The Missing Link in Thyroid & Chronic Disease with Dr. Nathan Bryan

In this episode, Dr. Eric Balcavage is joined by nitric oxide researcher and author Dr. Nathan Bryan, whose new book The Secret of Nitric Oxide explores why this tiny signaling molecule may be the key to preventing and reversing chronic illness.

Together, they dive deep into:

• What nitric oxide is and why it’s foundational for human health.

• How nitric oxide is made in the body—through both enzymatic and dietary pathways.

• The connection between nitric oxide, inflammation, oxidative stress, and the Cell Danger Response (CDR).

• How nitric oxide influences thyroid hormone production, conversion (T4 → T3), and the rise of reverse T3.

• Why loss of nitric oxide is one of the earliest triggers in chronic disease, including Hashimoto’s, cardiovascular disease, Alzheimer’s, and more.

• Common disruptors of nitric oxide production—nutrient deficiencies, environmental toxins, poor lifestyle habits, and even fluoride exposure.

• Practical steps to restore nitric oxide production naturally for better thyroid, metabolic, and overall health.

This is a powerful conversation that reframes nitric oxide not as just a cardiovascular molecule, but as a master regulator of cellular health, energy production, and thyroid physiology.

👉 If you’ve struggled with thyroid issues, chronic fatigue, or unexplained symptoms, this episode will help you see why restoring nitric oxide may be a critical missing piece in your recovery journey.

Dr. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport where he was the recipient of the Dean’s Award for Excellence in Research. He pursued his post-doctoral training as a Kirschstein Fellow at Boston University School of Medicine in the Whitaker Cardiovascular Institute. After a two-year post-doctoral fellowship, in 2006 Dr. Bryan was recruited to join faculty at the University of Texas Health Science Center at Houston by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology.

Dr. Bryan has been involved in nitric oxide research for the past 25 years and has made many seminal discoveries in the field. Dr. Bryan is a successful entrepreneur and Founder, Chairman and CEO of Bryan Therapeutics, Inc., a privately-held, clinical-stage biotechnology company that is actively engaged in the discovery and development of nitric oxide-based therapies. BTI has active drug development programs in heart disease, Alzheimers’ Disease and topical drugs for diabetic ulcer and non-healing wounds. Dr. Bryan’s consumer line of products are some of the most successful nitric oxide products on the market. Dr. Bryan is an international leader in molecular medicine and nitric oxide biochemistry.

Dr. Bryan's website: www.n1o1.com