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Metastatic BRCA-Negative Triple-Negative Breast Cancer — An Interview with Prof Peter Schmid on Optimal Management

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Manage episode 508092304 series 1464352
Content provided by Dr Neil Love. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Dr Neil Love or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

Featuring an interview with Prof Peter Schmid, including the following topics:

  • Response to immunotherapy in breast cancer subtypes (0:00)
  • Tolerability of TROP2 antibody-drug conjugates (ADCs) for metastatic breast cancer (mBC) (3:51)
  • Approaches to therapy for patients with HR-negative HER2-low and HER2-ultralow mBC (13:03)
  • ADC structure and treatment-related adverse events (19:02)
  • Available data from the Phase III ASCENT-04 trial evaluating sacituzumab govitecan with pembrolizumab as first-line therapy for patients with PD-L1-positive advanced triple-negative breast cancer (23:06)
  • Novel ADCs and bispecific antibodies under investigation for mBC (28:30)
  • Comparing datopotamab deruxtecan and sacituzumab govitecan for HR-positive disease (33:01)
  • Clinical investigator perspectives on the Phase III DESTINY-Breast09 trial evaluating first-line trastuzumab deruxtecan with or without pertuzumab versus THP (docetaxel/rastuzumab/pertuzumab) for HER2-positive mBC (35:06)

CME information and select publications

  continue reading

841 episodes

Artwork
iconShare
 
Manage episode 508092304 series 1464352
Content provided by Dr Neil Love. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Dr Neil Love or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://podcastplayer.com/legal.

Featuring an interview with Prof Peter Schmid, including the following topics:

  • Response to immunotherapy in breast cancer subtypes (0:00)
  • Tolerability of TROP2 antibody-drug conjugates (ADCs) for metastatic breast cancer (mBC) (3:51)
  • Approaches to therapy for patients with HR-negative HER2-low and HER2-ultralow mBC (13:03)
  • ADC structure and treatment-related adverse events (19:02)
  • Available data from the Phase III ASCENT-04 trial evaluating sacituzumab govitecan with pembrolizumab as first-line therapy for patients with PD-L1-positive advanced triple-negative breast cancer (23:06)
  • Novel ADCs and bispecific antibodies under investigation for mBC (28:30)
  • Comparing datopotamab deruxtecan and sacituzumab govitecan for HR-positive disease (33:01)
  • Clinical investigator perspectives on the Phase III DESTINY-Breast09 trial evaluating first-line trastuzumab deruxtecan with or without pertuzumab versus THP (docetaxel/rastuzumab/pertuzumab) for HER2-positive mBC (35:06)

CME information and select publications

  continue reading

841 episodes

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